Study of vitamin D level in patients with different etiologies of chronic liver disease and its correlation with Child Pugh class in a tertiary care centre in North India
DOI:
https://doi.org/10.18203/2320-6012.ijrms20231612Keywords:
Chronic liver disease, CTP score, Serum vitamin DAbstract
Background: Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D has a central role in developing hepatic deficiency of osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their and their relationship with disease advancement in these patients according to child Pugh-score. Aims and Objectives were study of vitamin D level in patients with different aetiology of chronic liver disease and its correlation with child Pugh score.
Methods: This was a cross sectional study conducted over 200 patients after applying inclusion and exclusion criteria in patients with different etiology of chronic liver disease.
Results: In our study total (N=200), 152 patients of alcoholic liver disease 41 patients having deficient vitamin D, 79 having insufficient vitamin D level and 32 patients having normal vitamin D level. Patients of chronic liver disease also have negative correlation on vitamin D level with Child Pugh score. In our study it was found that patients having higher Child Pugh score there is more chance of having vitamin D deficiency and insufficiency than the patient’s low Child Pugh score.
Conclusions: The prevalence of vitamin d deficiency in patients with CLD was found to be having a significant correlation with increasing CTP score with p value <0.001.
References
Kumar P, Chaudhry S, Dev N, Kumar R, Singh G. Serum 25-hydroxyvitamin D level in patients with chronic liver disease and its correlation with hepatic encephalopathy: A cross-sectional study. J Fam Med Prim Care. 2020;9(2):798-803.
Jamil Z, Arif S, Khan A, Durrani AA, Yaqoob N. Vitamin D deficiency and its relationship with Child-Pugh class in patients with chronic liver disease. J Clin Transl Hepatol. 2018;6(2):135-40.
Jatav JK, Shakya RK, Singh S. Study of lipid profile changes in cirrhosis of liver. Int J Scient Stud. 2018;6(3):108-14.
Unger LW, Forstner B, Schneglberger S, Muckenhuber M, Eigenbauer E, Scheiner B, et al. Patterns and prevalence of dyslipidemia in patients with different etiologies of chronic liver disease. Wiener Klinische Wochenschrift. 2019;131:395-403.
Sharma P, Arora A. Clinical presentation of alcoholic liver disease and non-alcoholic fatty liver disease: spectrum and diagnosis. Translat Gastroenterol Hepatol. 2020;5.
Konstantakis C, Tselekouni P, Kalafateli M, Triantos C. Vitamin D deficiency in patients with liver cirrhosis. Ann Gastroenterol. 2016;29(3):297-306.
Hoan NX, Khuyen N, Binh MT, Giang DP, Van Tong H, Hoan PQ, et al. Association of vitamin D deficiency with hepatitis B virus-related liver diseases. BMC Infect Dis. 2016;16(1):507.
Kalita S, Das J, Rajkakati R, Mili C. Vitamin D in patients of chronic liver disease with hepatic encephalopathy. J Assoc Phys India. 2022;70(4):11-12.
Dadabhai AS, Saberi B, Lobner K, Shinohara RT, Mullin GE. Influence of vitamin D on liver fibrosis in chronic hepatitis C: a systematic review and meta-analysis of the pooled clinical trials data. World J Hepatol. 2017;9(5):278-87.
Stokes CS, Volmer DA, Grünhage F, Lammert F. Vitamin D in chronic liver disease. Liver Int. 2013;33(3):338-52.
Asghar MS, Ahsan MN, Rasheed U, Hassan M, Jawed R, Abbas MB, et al. Severity of non-B and non-C hepatitis versus hepatitis b and c associated chronic liver disease: a retrospective, observational, comparative study. Cureus. 2020;12(12):e12294.
Rech MA, Von Roenn N, Durazo-Arvizu R, Cotler SJ, Kramer H. Vitamin D levels are associated with liver disease severity in patients with cirrhosis. J Ren Hep Disord. 2017;1(2):1-9.
Gupta BK, Saini ML, Nehara HR, Meena SL, Saini M, Gupta J. Evaluation of vitamin D deficiency in patients with chronic liver disease and its clinical significance. IJN. 2016;2(2):29-35.
