Effects of Englerina drummondii Balle ex Polhill and Wiens leaves extract on selected female rat organs’ weights

Barinua K. Gbaranor; Sam E. Kinako; Williams A. Mube; Abiye Tamuno-Opubo; David S. Kue; Lewis B. Lebara; Kianen Sekiita; Famba Famba D.; Vivian Ile; Gloria N. Nwosu; Ijeoma N. Amadi; Onita O. Ajumoke; Ucheawaji F. Edward; Faithwin Horsfall; Ihundah Nmehielle-Oluwadare; Henry A. Amadi-Ikpa; Rehan O. Berepele

doi:10.18203/2320-6012.ijrms20231307

Authors

Barinua K. Gbaranor Department of Human Physiology, College of Medical Science, Port Harcourt, Nigeria
Sam E. Kinako Department of Human Physiology, College of Medical Science, Port Harcourt, Nigeria
Williams A. Mube Department of Obstetrics and Gynecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria
Abiye Tamuno-Opubo Department of Human Physiology, College of Medical Science, Port Harcourt, Nigeria
David S. Kue Department of Surgery, College of Medical Science, Port Harcourt, Nigeria
Lewis B. Lebara Department of Obstetrics and Gynecology, College of Medical Sciences, Rivers State University Port Harcourt, Nigeria
Kianen Sekiita Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Nigeria
Famba Famba D. Department of Family Medicine, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Vivian Ile Department of Family Medicine, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Gloria N. Nwosu Department of Paediatrics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Ijeoma N. Amadi Department of Paediatrics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Onita O. Ajumoke Department of Nursing Science, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Ucheawaji F. Edward Department of Pharmacology and Therapeutics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Faithwin Horsfall Department of Obstetrics and Gynecology, College of Medical Sciences, Rivers State University Port Harcourt, Nigeria
Ihundah Nmehielle-Oluwadare Department of Pharmacology and Therapeutics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Henry A. Amadi-Ikpa Department of Human Anatomy, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
Rehan O. Berepele Department of Paediatrics, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20231307

Keywords:

Effects, Organs, Rats, Weight

Abstract

Background: Herbal medicine are patronized by several people across the globe This herbal medicine is routinely use and are more accessible and available. This study aimed to investigate the effects of Englerina drummondii Balle ex Polhill and Wiens leaves on rat organs (thyroid gland, kidneys, ovary and fallopian tubes) weights in female rats.

Methods: 20 female rats were selected randomly into 4 groups with 5 rats per group. Group 1 received 5 ml/kg of water, group 2 received extract 100 mg/kg, group 3 received extract 200 mg/kg, and group 4 received extract 400 mg/kg. Administration of extract was done for 28 days.

Results: The study revealed significance decreased in the weight of the left ovary organ when extract of medium dose (200 mg/kg) and high dose (400 mg/kg) was administered, as compared to control. The result also shows decrease in the organs weight of the thyroid gland, left kidney, right and left fallopian tubes extract of low, medium and high dose were administered. The right kidney shows increase when low dose extract was given but decrease when both low and medium dose of extract was given. However, this decrease is not significance and could be due to dose or time dependent. Statistical analysis was done using statistical package for the social sciences (SPSS) version 23 and p<0.05 was significant.

Conclusions: There was significance decreased in the weight of the left ovary organ when extract of medium dose (200 mg/kg) and high dose (400 mg/kg) was administered. Also, there is decrease in other organs weight when low, medium and high dose was given but not significance.

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