Comparison of ultrasonographically measured fetal interventricular septal thickness between diabetic and healthy mother


  • Yesmina Rahman Department of Radiology and Imaging, Evercare Hospital, Dhaka, Bangladesh
  • A. S. Mohiuddin Department of Radiology and Imaging, BIRDEM General Hospital, Dhaka, Bangladesh
  • Sadia Sultana Department of Radiology and Imaging, Square Hospital, Dhaka, Bangladesh
  • Nusrat Zahan Department of Radiology and Imaging, United Hospital, Dhaka, Bangladesh
  • Fatema Tuj Johora Department of Radiology and Imaging, Evercare Hospital, Dhaka, Bangladesh



Interventricular septum, GDM, USG


Background: During pregnancy, metabolic changes occur in response to increased nutrient needs of the fetus and mother, including progressive insulin resistance that can lead to gestational diabetes mellitus (GDM). GDM can result in fetal complications. This study aimed to compare fetal interventricular septal thickness, measured by ultrasound, between diabetic and healthy mothers.

Methods: This cross-sectional study was conducted at the department of radiology and imaging, BIRDEM, Dhaka, Bangladesh. A total of 334 subjects were enrolled in this study as per inclusion criteria. The study duration was 2 years; from July 2012 to June 2014. All study subjects were divided into 3 groups named group A, group B, and group C. 167 non-diabetic, 84 controlled diabetics, and 83 uncontrolled diabetic mothers were considered as group A, group B, and group C respectively. Data were analyzed by SPSS computed program.

Results: In this study, 47.9% of subjects in group A were ≤25 years old, while 52.4% of group B and 53.0% of group C were in the 26-30 age range. The mean age was 25.9±3 years in group A, 25.5±2.9 years in group B, and 25.2+3.3 years in group C, with no statistically significant difference between the three groups (p>0.05). The mean gestational age was similar across the three groups, with no statistically significant difference (p>0.05). However, the mean fetal interventricular septal thickness was significantly different between the groups, with group A and B having similar thicknesses, while group C had a significantly larger thickness (p<0.05). The difference in fetal interventricular septal thickness was also statistically significant between the three groups at 32 weeks of gestational age (p<0.05).

Conclusions: In this study, the fetal interventricular septal thickness was significantly higher in uncontrolled diabetic mothers followed by controlled diabetic and non-diabetic and almost alike between non-diabetic and controlled diabetic mothers. The study also revealed that M-mode ultra-sonogram measurement of interventricular septal thickness can be included in routine scanning during the third trimester.


Nashaat EH, Mansour GM. Uncontrolled Diabetes Mellitus and Fetal Heart', Researcher. 2020;2(S):45-55.

Jesmin S, Akter S, Akashi H, Al-Mamun A, Rahman MA, Islam MM et al. Screening for gestational diabetes mellitus and its prevalence in Bangladesh. Diabetes Res Clin Pract. 2014;103(1):57-62.

Golding J. ALSPAC (Avon Longitudinal Study of Parents and Children) Study Team. The outcome of pregnancy in diabetic women: more investigation is needed into whether control of diabetes is poorer in England than Norway. BMJ. 2001;322:614-5.

Fathi I. Diabetes mellitus and pregnancy. Libyan J Med. 2006;1(1):28-41.

Aroyo R, Rodriguez-Pinilla E, Cordero JF. Maternal diabetes: the risk for specific birth defects. Eur J Epidemiol. 1992;8:503-08.

Hornberger LK. Maternal diabetes and the fetal heart. Heart. 2006;92(8):1019-21.

Bánhidy F, Ács N, Puhó EH, Czeizel AE. Congenital abnormalities in the offspring of pregnant women with type 1, type 2 and gestational diabetes mellitus: A population‐based case‐control study. Congenital anomalies. 2010;50(2):115-21.

Kitzmiller J, Buchanan TA, Kjos S, Combs CA, Ratner RE. Preconception care of diabetes: Congenital malformations and spontaneous abortions. Diabetes Care. 1996;19(5):514-33.

Kafle P, Ansari MA, Khanal U. Fetal Cardiac Interventricular Septal Thickness at 28-37 Weeks of Gestation in Nepalese Population. NJR. 2012;22(3):36-42.

Cooper MJ, Enderlein MA, Tarnoff H, Roge CL. Asymmetric septal hypertrophy in infants of diabetic mothers. Fetal echocardiography and the impact of maternal diabetic control. Am J Dis Child. 1992;146(2):226-9.

Allan LID, Joseph MC. M-mode echocardiography in the developing human fetus. Br Heart J. 19982;47:573-83.

Patchakapat L, Uerpairojkit B, Wacharaprechanont T, Manotaya S, Tanawattanacharoen S, Charoenvidhya D. Interventricular Septal Thickness of Thai Fetuses: at 32 to 35 Weeks' Gestation. J Med Assoc Thai. 2006;89(6):748-54.

Zielinsky P, Hagemann LL, Lima RP, Sfoggia L, Krause DP. Prenatal Hypertrophic Cardiomyopathy and its Association with Amniotic Fluid Insulin in Fetuses of Diabetic Mothers. J Am Coll Cardiol. 1995;25(21):105-6.

Narchi HI, Kulaylat N. Heart disease in infants of diabetic mothers. Images Paediatr Cardiol. 2000;2(2):17-23.

Gandhi JA, Zhang XY, Maidman JE. Fetal cardiac hypertrophy ad cardiac function in diabetic pregnancies. Transactions of the FiftentAnualMectingOf The society Of Perinatal Obstetricians. Am J Obstetr Gynecol. 1995;173(4):1132-6.

Zielinsky P. Role of prenatal echocardiography in the study of hypertrophic cardiomyopathy in the fetus. Echocardiography. 1991;8(6):661-8.

Veille JC, Sivakoff M, Hanson R, Fanaroff AA. Interventricular septal thickness in fetuses of diabetic mothers. Obstetr Gynecol. 1992;79(1):51-4.

Veille JC, Hanson R, Steele L, Tatum K. M-mode echocardiographic evaluation of fetal and infant hearts: Longitudinal follow-up study from intrauterine life to year one. Am J Obstet Gynecol. 1996;175(4):922-8

Tan J, Silverman NH, Hoffman J, Villegas M, Schmidt KG. Cardiac dimensions determined by cross-sectional echocardiography in the normal human fetus from 18 weeks to term. Am J Cardiol, vol.1992;70(18):1459-67.

Weber HS, Copel JA, Reece EA, Green J, Kleinman CS. Cardiac growth in fetuses of diabetic mothers with good metabolic control. J Pediatr. 1991;118(1):103-7.




How to Cite

Yesmina Rahman, A. S. Mohiuddin, Sadia Sultana, Nusrat Zahan, & Fatema Tuj Johora. (2023). Comparison of ultrasonographically measured fetal interventricular septal thickness between diabetic and healthy mother. International Journal of Research in Medical Sciences, 11(5), 1450–1455.



Original Research Articles