Prognostic values of adiponectin and leptin in assessment of osteoarthritis in menopausal HIV women in Nauth Nnewi Nigeria

Ofia A. Kalu; Nkiruka R. Ukibe; Augustine C. Ihim; John E. Okwara; Perpetua A. Egwuatu; Gloria E. Ukibe; Blessing C. Ukibe

doi:10.18203/2320-6012.ijrms20231024

Authors

Ofia A. Kalu Department of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
Nkiruka R. Ukibe Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikive University, Awka, Anambra State, Nigeria
Augustine C. Ihim Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikive University, Awka, Anambra State, Nigeria
John E. Okwara Department of Chemical Pathology, College of Health Sciences, Nnamdi Azikive University, Awka, Anambra State, Nigeria
Perpetua A. Egwuatu Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikive University, Awka, Anambra State, Nigeria
Gloria E. Ukibe Department of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
Blessing C. Ukibe Department of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikive University, Awka, Anambra State, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20231024

Keywords:

HIV, Osteoarthritis, Menopause, Inflammation, Adipnectin, Leptin

Abstract

Background: Human immune deficiency virus (HIV) has progressively been implicated with development of inflammatory disease including osteoarthritis. This study evaluated serum levels of adiponectin and leptin in women living with HIV with/without osteoarthritis who have been placed on highly active anti-retroviral therapy (HAART) in NAUTH, Nnewi, Nigeria.

Methods: Eighty eight participants aged between 18 and 65 years attending HAART unit of NAUTH, Nnewi were randomly selected and grouped thus: Group A (premenopausal HIV seropositive women with osteoarthritis), group B (postmenopausal HIV seropositive women with osteoarthritis), group C (premenopausal HIV seropositive women) and group D (postmenopausal HIV seropositive women). Five milliliters of blood sample collected from each of participants for determination of adiponectin and leptin using enzyme linked immunosorbent assay (ELISA) technique.

Results: Adiponectin level was significantly higher in postmenopausal HIV seropositive women with osteoarthritis compared with pre and postmenopausal HIV seropositive women without osteoarthritis (p<0.05 respectively). Similarly, leptin level was significantly higher in pre and post-menopausal HIV seropositive women with osteoartritis compared with their counterparts without osteoarthritis (p<0.05 respectively). A positive significant correlation was observed between Leptin and age in premenopausal HIV seropositive women with osteoarthritis. Also, a significant negative correlation was observed between adiponectin, age in pre and postmenopausal HIV seropositive women without osteoarthritis.

Conclusions: The significant increases in adiponectin and leptin levels in pre and postmenopausal HIV seropositive women can be linked to severe inflammatory reaction due to osteoarthritis which might have been aggravated by combined effects of menopause and HIV infection.

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References

Grotle M, Hagen KB, Natvig B. Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BioMed Central Musculoskelet Disor. 2008;9:132.

Bijlsma JWJ, Berenbaum F, Lafeber FPJG. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377:211-26.

Courties A, Gualillo O, Berenbaum F. Metabolic stress-induced joint inflammation and osteoarthritis. Osteoarthrit Cartilage. 2015;23(19):55-65.

Yusuf E, Nelissen RG, Ioan-Facsinay A. Association between weight or body mass index and hand osteoarthritis: a systematic review. Ann Rheum Dis.. 2010;69:76-7.

Puenpatom RA, Victor TW. Increased prevalence of metabolic syndrome in individuals with osteoarthritis: an analysis of NHANES III data. Postgraduate Med J 2009;121:9-20.

Visser AW, De Mutsert R, le Cessie S. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study. Ann Rheum Dis. 2015;74:184-7.

Alencastro PR, Wolff FH, Oliveira RR. Metabolic syndrome and population attributable risk among HIV/AIDS patients: comparison between NCEP-ATPIII, IDF and AHA/NHLBI definitions. AIDS Resear Ther. 2012;9:29.

Koethe JR, Lagathu C, Lake JE, Domingo P, Calmy A, Falutz J et al. HIV and antiretroviral therapy-related fat alterations. Nat Rev Dis Primers. 2020;6:48.

Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: Influences of age, gender and osteoarthritis affecting other joints. Ann Rheumat Dis. 2014;73:165-7.

Gabay O. Osteoarthritis: new perspectives. Joint Bone Spine J. 2012;1.

Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H. Osteoarthritis. Lancet 2015;386:376-87.

Gabay O, Hall DJ, Berenbaum F, Henrotin Y, Sanchez C. Osteoarthritis and obesity: experimental models. Joint Bone Spine J. 2008;75:675-9.

Ibrahim SM, Hamdy MS, Amer N. Plasma and synovial fluid adipocytokines in patients with rheumatoid arthritis and osteoarthritis. Egyptiam J Immunol. 2010;15:159-70.

Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C et al. new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthrit Cartilage. 2008;16:1101-9.

Cuzdan-Coskun N, Ay S, Evcik FD, Oztuna D. Adiponectin: is it a biomarker for assessing the disease severity in knee osteoarthritis patients? Inter J Rheum Dis. 2017;20:194-6.

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophysic Resear Com. 2012;425:560-4.

Perakakis N, Farr OM, Mantzoros CS, Leptin in Leanness and Obesity: JACC State-of-the-Art Review. J Am College Cardiol. 2021;77(6):745-60.

Upadhyay J, Farr OM, Mantzoros CS. The role of leptin in regulating bone metabolism. Metab 2015;64(1):105-13.

Kume K, Satomura K, Nishisho S, Kitaoka E, Yamanouchi K, Tobiume S et al. Potential Role of Leptin in Endochondral Ossification. J Histochem Cytochem. 2002;50(2):159-69.

Ait Eldjoudi D, Cordero Barreal A, Gonzalez-Rodríguez M, Ruiz-Fernández C, Farrag Y, Farrag M, et al. Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander? Int J Mol Sci. 2022;23(5):2859.

Marks R, Allegrante JP. Body mass indices in patients with disabling hip osteoarthritis. Arthritis Res. 2002;4:112-6.

Ismail SA, Mwafey I, Mohamed SA. Serum levels of adiponectin and visfatin in patients with lichen planus: a case-controlled study. Al-Azhar Assiut Med J. 2017;15:122-6.

Chavarria-Avila E, Vazquez-Del Mercado M, Gomez-Banueloes E, Ruiz-Quezada S, Castro-Albarran J, Sanchez-Lopez L. The impact of LEP G-2548A and LEPR G223Arg Polymorphism on adiposity, leptin, and leptin-Receptor serum levels in a mexico Mestizo population. BioMed Resear Inter. 2015;539408.

World Health Organisation. WHO STEPS Surveilance Part 3: Training and Practical Guides Geneva Switzerland: WHO. 2008. Available at: https://www3.paho.org/english/ad/dpc/nc/panam-steps-manual. Accessed on 3 June 2022.

Francin PJ, Abot A, Guillaume C, Moulin D, Bianchi A, Gegout-Pottie P, et al. Association between adiponectin and cartilage degradation in human osteoarthritis. Osteoarthrit Cartilage. 2014;22:519-26.

Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287:356-9.

Grundy SM. Obesity, metabolic syndrome and cardiovascular disease. J Clin Endocrinol Metab. 2004;89:2595-600.

Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis. 2006;65:1198-201.

Filková M, Lišková M, Hulejová H, Haluzík M, Gatterová J, Pavelková A et al. Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis. Ann Rheum Dis. 2009;68:295-6.

Jones S, Waitt C, Back D, Pirmohamed M. Effect of NRTI and PI on TNF-alpha and adiponectin mRNA expression in isolated subcutaneous and omental mature human adipocytes. 11th Conf. on Retroviruses and Opportunistic Infections; San Francisco, CA. 2004.

Fantuzzi, G. Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol. 2008;121:326-30.

Wu J, Xu J, Wang K, Zhu O, Cai J, Ren J et al. Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study. BMC Musculoskelet Disord. 2018;19:16.

Iliopoulos D, Malizos KN, Tsezou A. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheumatic Dis. 2007;66:161-3.

Greene MA, Loeser RF, Aging-related inflammation in osteoarthritis. Osteoarthr Cartilage. 2015;23(11):1966-71.

Yamauchi T, Kamon J, Minokoshi YA, Ito Y, Waki H, Uchida S et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating amp-activated protein kinase. Nat Med. 2002;8(12)88-95.

Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulat 2002;106:2767-70.

Sereti I, Altfeld M. Immune activation and HIV: an enduring relationship. Cur Opin HIV AIDS 2016;11(2):129-40.

Ukibe SN, Ugorji TN, Ikeakor LC, Obi-Okaro AC, Ukibe NR, Ekezie J et al. Epidemiology and Pattern of Osteoarthritis at Ogbaku, Imo State University Teaching Hospital Annex, Mbaitoli Local Government Area, Imo State, Southeast, Nigeria J Advances Med Med Res. 2015;827-32.

Imai K, Sutton MY, Mdodo R, Del Rio C. HIV and menopause: a systematic review of the effects of HIV infection on age at menopause and the effects of menopause on response to antiretroviral therapy. Obstetr Gynecol Int. 2013;1:11-3.