Clinico-epidemiological features of hypopharyngeal cancer patients presenting at Bangabandhu Sheikh Mujib medical university, Bangladesh
DOI:
https://doi.org/10.18203/2320-6012.ijrms20231038Keywords:
Clinico-epidemiological, Hypopharyngeal cancer, Cross-sectional studyAbstract
Background: In Bangladesh, hypopharyngeal cancer is one of the most prevalent cancers in head neck region. In this study, the clinico-epidemiological characteristics of patients with hypopharyngeal cancer were evaluated.
Methods: From November 2021 to October 2022, 172 patients with hypopharyngeal carcinoma were included in this descriptive, cross-sectional study at Bangabandhu Sheikh Mujib medical university's department of clinical oncology. During in-person interviews, data were gathered from patients using a pre-made questionnaire.
Results: The mean age of the patients was 54.42 (±7.652) years, and the majority of them (59.3%) were between the ages of 51 and 60. Male patients made up 81.4% of the total patient population, and 51.16% of them were farmers. The majority of the cases (79.07%) consumed tobacco. Squamous cell carcinoma was the most prevalent histological type among the patients (92%), and most of them had a moderate degree of differentiation (65.12%). The pyriform fossa (81.4%) was the most common primary sub site.
Conclusions: In conclusion, tobacco users and middle-aged men are more likely to develop hypopharyngeal cancer. The most common histological type is moderately differentiated squamous cell carcinoma, with tumours most commonly seen in the pyriform fossa of hypopharynx.
References
DeVita Jr. V, Lawrence T, Rosenberg S. DeVita, Hellman, and Rosenberg's cancer: Principles and Practice of Oncology. 11th ed. Philadelphia: Wolters Kluwer. 2019;999.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
Lim SH, Sun J-M, Hong J, Oh D, Ahn YC, Chung MK, et al. Concurrent chemoradiotherapy (CCRT) versus induction docetaxel, cisplatin and 5-fluorouracil (TPF) followed by CCRT in locally advanced hypopharyngeal and base of tongue cancer: A randomized phase II study. Annals of Oncology. 2017;28:v385
Bangladesh Global Cancer Observatory, 2018. Available at: https://gco.iarc.fr/today/data/factsheets/ populations/50-bangladesh-fact-sheets.pdf. Accessed on 10 February 2023.
Cancer Registry Report, 2014. Available at: www.dghs.gov.bd/index.php/en/publications/477-other-pu blications. Accessed on 10 February 2023.
Hoffman HT, Karnell LH, Shah JP, Ariyan S, Brown GS, Fee WE, et al. Hypopharyngeal Cancer Patient Care Evaluation. Laryngoscope. 1997;107(8):1005-17.
Krstevska V. Early stage squamous cell carcinoma of the pyriform sinus: A review of treatment options. Indian J Cancer. 2012;49(2):236.
Kurumatani N, Kirita T, Zheng Y, Sugimura M, Yonemasu K. Time trends in the mortality rates for tobacco- and alcohol-related cancers within the oral cavity and pharynx in Japan, 1950-94. J. Epidemiol. 1999;9(1):46-52.
Macfarlane GJ, Zheng T, Marshall JR, Bo#etta P, Niu S, Brasure J, et al. Alcohol, tobacco, diet and the risk of oral cancer: a pooled analysis of three case-control studies. Eur J Cancer B Oral Oncol. 1995;31(3):181-7.
Taha MS, Sobhy TS, Hamid OM, Alfeky LM, Ebrahim SA, Alaziz HMA, et al. Concurrent radiochemotherapy versus surgery followed by radiotherapy for hypopharyngeal carcinoma: A single-center study. Egypt J Ear, Nose Throat Allied Sci. 2013;14(3):175-83.
Halperin E, Wazer D, Perez C, Brady L. Perez and Brady's Principles and Practice of Radiation Oncology. 7th ed. Philadelphia: Wolters Kluwer. 2018;2796.
Hall SF, Groome PA, Irish J, O’Sullivan B. The Natural History of Patients With Squamous Cell Carcinoma of the Hypopharynx. Laryngoscope. 2008;118(8):1362-71.
Jyoti D, Arti, Kunzes, Jamwal PS. Clinical profile of the patients presenting with laryngeal and hypopharyngeal cancinoma: an institution based retrospective study. Int J Otorhinolaryngol Head Neck Surg. 2019;5(5):1161.
Islam MN, Lodh D, Siddiqui MM, Khan AM, Meherunnesa K. Clinicopathological Study on Hypopharyngeal Carcinoma in Dhaka Medical College Hospital. Bangl J Otorhinolaryngol. 2016;21(2):85-9.
Aich M, Joarder MAH, Datta P, Alauddin M. Hypopharyngeal carcinoma: a clinical study. Bangl J Otorhinolaryngol. 1970;14(1):23-9.
Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin, et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 1988;48(11):3282-7.
Ruback Maurício JC, Galbiatti AL, Arantes Lidia Maria RB, Marucci GH, Russo A, Ruiz-Cintra MT, et al. Clinical and epidemiological characteristics of patients in the head and neck surgery department of a university hospital. Sao Paulo Med. J. 2012;130(5):307-13.
Stoyanov GS, Kitanova M, Dzhenkov DL, Ghenev P, Sapundzhiev N. Demographics of Head and Neck Cancer Patients: A Single Institution Experience. Cureus. 2017;9(7):1418.
Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer. 1999;80(6):827-41.
