Neuromyelitis optica and liver cirrhosis: an association or co-incidence
DOI:
https://doi.org/10.18203/2320-6012.ijrms20231664Keywords:
NMO, Cirrhosis, QuadriparesisAbstract
Neuromyelitis optica (NMO) is a rare central nervous system demyelination syndrome predominantly targeting optic nerves and the spinal cord. Here we present a middle-aged female presenting with new onset quadriparesis and a history of persistent splenomegaly and pancytopenia, eventually being diagnosed as NMO along with autoimmune cirrhosis. The association of NMO spectrum disorders (NMOSD) with chronic liver disease has not been previously described in the literature. The purpose of this case report is to bring forward an unusual presentation and to ascertain whether it could be part of a heterogenous spectrum of an autoimmune disorder, or merely a co-incidence.
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Jindahra P, Plant T. Update on neuromyelitis optica: natural history and management. Eye Brain. 2012;26:27-41.
Lucchinetti CF, Guo Y, Popescu BF, Fujihara K, Itoyama Y, Misu T. The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica. Brain Pathol. 2014;24:83-97.
Elnady B, Fathy SM, Elkhouly T. Neuromyelitis optica spectrum standstill in rheumatic systemic autoimmune diseases. Egypt Rheumatol Rehabil. 2010;47:15.
Schuppan D, Afdhal NH: Liver cirrhosis. Lancet. 2008;8:838-51.
Wiegand J, Berg T. The etiology, diagnosis and prevention of liver cirrhosis: part 1 of a series on liver cirrhosis. Dtsch Arztebl Int. 2013;110:85-91.
Oliveira MSM, Pires J, Saudade RJ. Association of autoimmune hepatitis and multiple sclerosis: a coincidence? Mult Scler. 2005;11(6):691-3.
Romanelli RG, Fassio F, Cappelli F. Autoimmune hepatitis in a patient affected by neuromyelitis optica: a new association. Clin Res Hepatol Gastroenterol. 2014;38:33-5.
Lu F, Xia Q, Ma Y. Serum proteomic-based analysis for the identification of a potential serological marker for autoimmune hepatitis. Biochem Biophys Res Commun. 2008;7:284-90.
Kimura A, Sakurai T, Koumura A. High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases. J Neuroimmunol. 2010;219:105-8.
Mangioni D, Soria A, Brighina L, Bandera A, Ferrarese C: Gori A. A case of classic neuromyelitis optica (Devic's syndrome) triggered by pegylated-interferon α. BMC Pharmacol Toxicol. 2014;30:56.
Ershadinia N, Mortazavinia N, Babaniamansour S, Najafi-Nesheli M, Babaniamansour P, Aliniagerdroudbari E: The prevalence of autoimmune diseases in patients with multiple sclerosis: A cross-sectional study in Qom, Iran, in 2018. Curr J Neurol. 2020;5:98-102.
Mack CL, Adams D, Assis DN. Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases. Hepatology. 2020;72(2):671-722.
Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmmune hepatitis. Cell Mol Immunol. 2022;19(2):158-76.
Carnero Contentti E, Correale J. Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies. J Neuroinflammation. 2021;18(1):208.
Papadopoulos MC, Verkman AS: Aquaporin 4 and neuromyelitis optica. Lancet Neurol. 2012;11(6):535-44.
Tsouris Z, Liaskos C, Dardiotis E. A comprehensive analysis of antigen-specific autoimmune liver disease related autoantibodies in patients with multiple sclerosis. Auto Immun Highlights. 2020;11:1-7.
Sayin R, Gokgul A, Ebinc S, Dulger AC, Tombul T. Clinical Overlap of Multiple Sclerosis and Autoimmune Hepatitis: Three Cases. J Coll Physicians Surg Pak. 2016;26(6):S45-7.
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