Estimation of adiponectin levels in diabetic, non-diabetic fatty liver diseases and healthy controls

Authors

  • Ashish Kumar Pandey Department of Gastroenterology, M.S. Ramaiah Medical College and Hospitals, Bangalore, Karnataka
  • Umesh Jalihal Department of Gastroenterology, M.S. Ramaiah Medical College and Hospitals, Bangalore, Karnataka
  • Pramila Kalra Department of Endocrinology, M.S. Ramaiah Medical College and Hospitals, Bangalore, Karnataka
  • Vanitha MN. Gowda Department of Biochemistry, M.S. Ramaiah Medical College and Hospitals, Bangalore, Karnataka
  • Vinay MD. Prabhu Department of Radiodiagnosis, M.S. Ramaiah Medical College and Hospitals, Bangalore, Karnataka

Keywords:

Adiponectin, Fatty liver, Diabetes mellitus, Non-alcoholic fatty liver diseases

Abstract

Background:Estimation of adiponectin levels in diabetic and non-diabetic fatty liver and healthy controls.

Methods:We studied 25 subjects for diabetic fatty liver, 25 subjects for non-diabetic fatty liver and 25 healthy controls. Clinical evaluation included anthropometric measurements, BMI, biochemical investigations and adiponectin estimation by ELISA.

Results: There were 15 males (60%) and 10 (40%)females subjects in the DFL group, 18 males (72%) and 7 females (28%) subjects in the NDFL group and 13 males (52%) and 12 females (48%) subjects in the control group. 80% (20) of the DFL patients and 72% (18) subjects of NDFL group had BMI >25kg/m2. 80% (12 males and 8 females) of subjects in the DFL group and 68% (12 males and 5 females) had a waist circumference that indicated central obesity as per Indian cut-offs (>90 cm for females and >80 cm for males). The mean adiponectin (μg/ml) ± SD levels in DFL were 4.03 ± 0.43, NDFL was 5.01 ± 0.55 and in controls was 7.63 ± 0.66, the difference being statistically significant with P <0.001. The difference in the adiponectin levels was statistically significant between each of the three groups with P <0.001. There was no difference in serum adiponectin levels between males and females in all three groups.

Conclusion:The chief conclusion of this study are that serum adiponectin levels are lower in subjects with NAFLD than those without it; adiponectin levels are inversely related to the degree of steatosis in NAFLD, with the lowest levels in more severe forms of steatosis.

 

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Published

2017-01-05

How to Cite

Pandey, A. K., Jalihal, U., Kalra, P., Gowda, V. M., & Prabhu, V. M. (2017). Estimation of adiponectin levels in diabetic, non-diabetic fatty liver diseases and healthy controls. International Journal of Research in Medical Sciences, 3(1), 140–146. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/1221

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Original Research Articles