Association of serum uric acid level with angiographic severity of coronary artery disease: a study in a tertiary care hospital, Chittagong, Bangladesh

Khondaker M. Ismail; Prabir Kumar Das; Anisul Awal; Saurav Das; Sayem Bin Latif; M. A. B. K. Bashiruddin; M. Mehadi Hasan; Tania Easmin Eva; M. Sawkat Hossan; Partha Bhattacharyya

doi:10.18203/2320-6012.ijrms20231604

Authors

Khondaker M. Ismail OSD (DGHS), Deputed to Chittagong Medical College, Chattogram, Bangladesh
Prabir Kumar Das Department of Cardiology, Chittagong Medical College, Chattogram, Bangladesh
Anisul Awal Department of Cardiology, Chittagong Medical College, Chattogram, Bangladesh
Saurav Das OSD (DGHS), Deputed to Chittagong Medical College, Chattogram, Bangladesh
Sayem Bin Latif Department of Cardiology, Chittagong Medical College, Chattogram, Bangladesh
M. A. B. K. Bashiruddin OSD (DGHS), Deputed to Chittagong Medical College, Chattogram, Bangladesh
M. Mehadi Hasan OSD (DGHS), Deputed to Dhaka Medical College, Dhaka, Bangladesh
Tania Easmin Eva OSD (DGHS), Deputed to Dhaka Medical College, Dhaka, Bangladesh
M. Sawkat Hossan OSD (DGHS), Deputed to Chittagong Medical College, Chattogram, Bangladesh
Partha Bhattacharyya OSD (DGHS), Deputed to Chittagong Medical College, Chattogram, Bangladesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20231604

Keywords:

CAD, SUA, Gensini score, CAG

Abstract

Background: Coronary artery disease (CAD) is a major global health issue. Serum uric acid (SUA), a byproduct of purine metabolism, is linked to CAD development and progression. Elevated SUA levels are an independent risk factor for cardiovascular mortality and may indicate endothelial dysfunction. The aim of the study was to the observed associate serum uric acid level with the angiographic severity of CAD.

Methods: This observational study was conducted at Chittagong medical college hospital in Bangladesh from October 2020 to September 2021. It included 130 patients and used unpaired t-tests to analyze the association between serum uric acid level and angiographic severity of CAD patients. Ethical clearance was obtained from the institutional review board of Chittagong medical college and hospital.

Results: A study of 130 patients found a significant relationship between serum uric acid (SUA) levels and CAD (CAD), vessel involvement, and CAD severity (p=0.001). Patients with CAD had higher SUA levels (mean 5.26±1.32 mg/dL) compared to those without CAD (mean 4.22±1.03 mg/dL). A SUA level range of 3.94-6.58 mg/dL was associated with CAD presence. Gender also showed a highly significant association with SUA levels (p=0.001), while age, BMI, and smoking status did not show significant differences.

Conclusions: A strong positive association has been found between serum uric acid level and the severity of CAD. The findings of this study approve the effectiveness of hyperuricemia as an emerging risk factor for CAD.

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