The first year of the COVID-19 pandemic in nursing homes: a meta-analysis study

Authors

  • Sevda Sungur Department of Public Health, Medical Faculty, Eskişehir Osmangazi University, Eskişehir, Türkiye
  • Selma Metintaş Department of Public Health, Medical Faculty, Eskişehir Osmangazi University, Eskişehir, Türkiye
  • Ali Kılınç Beyşehir County Health Directorate, Konya, Türkiye
  • Didem Oktar Department of Public Health, Medical Faculty, Eskişehir Osmangazi University, Eskişehir, Türkiye
  • Muhammed Fatih Önsüz Department of Public Health, Medical Faculty, Eskişehir Osmangazi University, Eskişehir, Türkiye

DOI:

https://doi.org/10.18203/2320-6012.ijrms20232113

Keywords:

Nursing homes, COVID-19, Older adult, Meta-analysis, Mortality rate

Abstract

Severe impact of COVID-19 on nursing homes and the morbidity and mortality rates in nursing home residents can be higher than in the community during a pandemic. This study aimed to meta-analyse the COVID-19 attack, fatality and mortality rates among nursing home residents and to meta-analyse the risk ratio values by comparing these rates with those of the countries in which the nursing homes are located. The data was obtained from COVID-19 attack, mortality, and fatality rates of nursing home residents. Additional meta-analysis was performed using risk ratio calculated by dividing the data obtained from nursing homes by the expected numbers calculated using case, death, and population data from COVID-19. A total of 6,758,241 COVID-19 patients from 8 different countries and 19 studies were included during the meta-analysis study period. In nursing home residents compared to the general population, the risk ratio (95%CI) for COVID-19 attack rate was 148.19 (99.45 to 220.82), the mortality rate was 341.16 (211.94 to 549.15), and the fatality rate was 2.36 (1.90 to 2.93) (each p<0.001). A meta-analysis of well-documented studies has shown that community morbidity and mortality rates can reach higher levels compared to community during a pandemic. Finding the exact causes can only be achieved after adjusting nursing home infection rates with regional rates. To ensure better community management of the COVID-19 pandemic and prevent future pandemics, preventive measures should be taken earlier.

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References

Ribbe MW, LJuneggren G, Steel K, Topinková E, Hawes C, Ikegami N, et al. Nursing homes in 10 nations: a comparison between countries and settings. Age Ageing. 1997;26(2):3-12.

Gorges RJ, Konetzka RT. Staffing Levels and COVID-19 Cases and Outbreaks in U.S. Nursing Homes. J Am Geriatr Soc. 2020;68(11):2462-6.

Koshkouei M, Abel L, Pilbeam C. How can pandemic spreads be contained in care homes? Pan American Health Organization, 2021. Available at: https://covid19evidence.paho.org/handle/20.500.12663/1151. Accessed on 19 May 2023.

Chatterjee P, Kelly S, Qi M, Werner RM. Characteristics and Quality of US Nursing Homes Reporting Cases of Coronavirus Disease 2019 (COVID-19). JAMA Netw Open. 2020;3(7):e2016930.

Centers for Disease Control and Prevention. COVID-19 Nursing Home Data, 2021. Available at: https://data.cms.gov/covid-19/covid19nursinghome-data. Accessed on 19 May 2023.

Arlotti M, Ranci C. The Impact of COVID-19 on Nursing Homes in Italy: The Case of Lombardy. J Aging Soc Policy. 2021;33(4-5):431-43.

Adelina CH, Disha P, Greg A, Joel M, Andrea S. International data on deaths attributed to COVID-19 among people living in care homes. International Long-Term Care Policy Network, 2022. Available at: https://ltccovid.org/2022/02/22/international-data-on-deaths-attributed-to-covid-19-amongpeople-living-in-care-homes. Accessed on 12 Marchch 2023.

Hamilton WL, Tonkin-Hill G, Smith ER, Aggarwal D, Houldcroft CJ, Warne B, et al. Genomic epidemiology of COVID-19 in care homes in the east of England. Elife. 2021;10:e64618.

McMichael TM, Clark S, Pogosjans S, Kay M, Lewis J, Baer A, et al. COVID-19 in a Long-Term Care Facility - King County, Washington, February 27-Marchch 9, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(12):339-42.

Sun CLF, Zuccarelli E, Zerhouni EGA, Lee J, Muller J, Scott KM, et al. Predicting Coronavirus Disease 2019 Infection Risk and Related Risk Drivers in Nursing Homes: A Machine Learning Approach. J Am Med Dir Assoc. 2020;21(11):1533-8.

Fischer R. Impact Of Evacuatıng Skılled Nursıng Home Resıdents Testıng Posıtıve For Covıd-19 To An Inpatıent Acute Care Settıng. J Nurs Home Res. 2020;(6):69-72.

Graham NSN, Juneghans C, Downes R, Sendall C, Lai H, McKirdy A, et al. SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes. J Infect. 2020;81(3):411-9.

National Institute for Health Research. PROSPERO International prospective register of systematic reviews, 2023. Available at: https://www.crd.york.ac.uk/prospero. Accessed on 11 January 2023.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement. J Clin Epidemiol. 2021;134:103-12.

Worldometer. Countries in the world by population, 2021. Available at: https://www.worldometers.info/worldpopulation/population-by-country/. Accessed on 10 Marchch 2023.

European Centre for Disease Prevention and Control. On the daily number of new reported COVID-19 cases and deaths worldwide, 2021 Available at: https://www.ecdc.europa.eu/en/publicationsdata/download-todays-data-geographic-distribution-covid-19-cases-worldwide. Accessed on 10 Marchch 2023.

Fung HF, Marchtinez L, Alarid-Escudero F, Salomon JA, Studdert DM, Andrews JR, et al. The Household Secondary Attack Rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Rapid Review. Clin Infect Dis. 2021;73(2):S138-45.

Wells GA, Shea B, Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analyses, 2000. Available at: https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed on 10 May 2023.

Cohen J. A coefficient of agreement for nominal scales. Edu Psychol Measurm. 1960;20(1):37-46.

Altman DG. Practical statistics for medical research. 1st ed. Chapman and Hall; 1990.

Bernabeu-Wittel M, Ternero-Vega JE, Díaz-Jiménez P, Conde-Guzmán C, Nieto-Marchtín MD, Moreno-Gaviño L, et al. Death risk stratification in elderly patients with covid-19. A comparative cohort study in nursing homes outbreaks. Arch Gerontol Geriatr. 2020;91:104240.

Blain H, Rolland Y, Tuaillon E, Giacosa N, Albrand M, Jaussent A, et al. Efficacy of a Test-Retest Strategy in Residents and Health Care Personnel of a Nursing Home Facing a COVID-19 Outbreak. J Am Med Dir Assoc. 2020;21(7):933-6.

Strazzulla A, Tarteret P, Postorino MC, Picque M, de Pontfarcy A, Vignier N, et al. Fighting COVID-19 spread among nursing home residents even in absence of molecular diagnosis: a retrospective cohort study. Res Square. 2020;1-12.

Echeverría P, Mas Bergas MA, Puig J, Isnard M, Massot M, Vedia C, et al. App as an Innovative Strategy for the Management and Follow-Up of COVID-19 Cases in Long-Term Care Facilities in Catalonia: Implementation Study. JMIR Public Health Surveill. 2020;6(3):e21163.

Klein A, Edler C, Fitzek A, Frob D, Heinemann A, Meissner K, et al. The first COVID-19 hotspot in a retirement home in Hamburg. Rechtsmedizin (Berl). 2020;30(5):325-31.

Sanchez GV, Biedron C, Fink LR, Hatfield KM, Polistico JMF, Meyer MP, et al. Initial and Repeated Point Prevalence Surveys to Inform SARS-CoV-2 Infection Prevention in 26 Skilled Nursing Facilities - Detroit, Michigan, Marchch-May 2020. MMWR Morb Mortal Wkly Rep. 2020;69(27):882-6.

Schols J, Poot E, Nieuwenhuizen N, Achterberg W. Dealing With Covid-19 In Dutch Nursing Homes. Jour Nursing Home Res. 2020;(6):30-4.

Veronese N, Sbrogiò LG, Valle R, Marchin L, Boscolo Fiore E, Tiozzo A. Prognostic Value of Lung Ultrasonography in Older Nursing Home Residents Affected by COVID-19. J Am Med Dir Assoc. 2020;21(10):1384-6.

Brown KA, Jones A, Daneman N, Chan AK, Schwartz KL, Garber GE, et al. Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada. JAMA Intern Med. 2021;181(2):229-36.

Rutten JJS, Loon AM, Kooten J, Buul LW, Joling KJ, Smalbrugge M, et al. Clinical Suspicion of COVID-19 in Nursing Home Residents: Symptoms and Mortality Risk Factors. J Am Med Dir Assoc. 2020;21(12):1791-7.

Dolveck F, Strazzulla A, Noel C, Aufaure S, Tarteret P, Pontfarcy A, et al. COVID-19 among nursing home residents: results of an urgent pre-hospital intervention by a multidisciplinary task force. Braz J Infect Dis. 2021;25(1):101039.

Patel MC, Chaisson LH, Borgetti S, Burdsall D, Chugh RK, Hoff CR, et al. Asymptomatic SARS-CoV-2 Infection and COVID-19 Mortality During an Outbreak Investigation in a Skilled Nursing Facility. Clin Infect Dis. 2020;71(11):2920-6.

Tang O, Bigelow BF, Sheikh F, Peters M, Zenilman JM, Bennett R, et al. Outcomes of Nursing Home COVID-19 Patients by Initial Symptoms and Comorbidity: Results of Universal Testing of 1970 Residents. J Am Med Dir Assoc. 2020;21(12):1767-73.

Tarteret P, Strazzulla A, Rouyer M, Gore C, Bardin G, Noel C, et al. Clinical features and medical care factors associated with mortality in French nursing homes during the COVID-19 outbreak. Int J Infect Dis. 2021;104:125-31.

Arons MM, Hatfield KM, Reddy SC, Kimball A, James A, Jacobs JR, et al. Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. N Engl J Med. 2020;382(22):2081-90.

Cangiano B, Fatti LM, Danesi L, Gazzano G, Croci M, Vitale G, et al. Mortality in an Italian nursing home during COVID-19 pandemic: correlation with gender, age, ADL, vitamin D supplementation, and limitations of the diagnostic tests. Aging (Albany NY). 2020;12(24):24522-34.

Ly TDA, Zanini D, Laforge V, Arlotto S, Gentile S, Mendizabal H, et al. Pattern of SARS-CoV-2 infection among dependant elderly residents living in long-term care facilities in Marchseille, France, Marchch-Junee 2020. Int J Antimicrob Agents. 2020;56(6):106219.

Ventura F, Molinelli A, Barranco R. COVID-19-related deaths in residential care homes for elderly: The situation in Italy. J Forensic Leg Med. 2021;80:102179.

Comas-Herrera A, Zalakaín J, Lemmon E, Henderson D, Litwin C, Hsu AT, et al. Updated international report on COVID-19 related mortality in care homes. LTCcovid, 2020. Available at: https://ltccovid.org/2020/04/12/mortalityassociated-withcovid19outbreaksincarehomesearlyinternational-evidence. Accessed on 12 Junee 2022.

Fisman DN, Bogoch I, Lapointe-Shaw L, McCready J, Tuite AR. Risk Factors Associated With Mortality Among Residents With Coronavirus Disease 2019 (COVID-19) in Long-term Care Facilities in Ontario, Canada. JAMA Netw Open. 2020;3(7):e2015957.

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Published

2023-06-30

How to Cite

Sungur, S., Metintaş, S., Kılınç, A., Oktar, D., & Önsüz, M. F. (2023). The first year of the COVID-19 pandemic in nursing homes: a meta-analysis study. International Journal of Research in Medical Sciences, 11(7), 2639–2648. https://doi.org/10.18203/2320-6012.ijrms20232113

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Section

Meta-Analysis