Survival analysis of hospitalized COVID-19 patients in New Yangon General Hospital by prognostic indicators

Authors

  • Thant Syn Htoo Department of Medicine, University of Medicine 1, Yangon, Myanmar
  • Swe Mar Myint Lwin Department of Health Behavior and Communication, University of Public Health, Myanmar
  • May Soe Aung Department of Preventive and Social Medicine, University of Medicine 1, Yangon, Myanmar
  • Thin Thin Nwe Department of Medicine, University of Medicine 1, Yangon, Myanmar

DOI:

https://doi.org/10.18203/2320-6012.ijrms20232177

Keywords:

Hospitalized COVID-19 patients, New Yangon General Hospital, Prognostic indicators

Abstract

Background: Coronavirus disease (COVID-19) is an infectious disease of the SARS-CoV-2 virus and it can infect anyone resulting in serious illness and death.

Methods: A retrospective cohort study was conducted in New Yangon General Hospital (NYGH), Yangon between September and November, 2022. Previous records of COVID-19 in-patients admitted to NYGH from 1st June to 31st October, 2021, were reviewed. COVID-19 in-patients who tested positive by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) or rapid diagnostic test (RDT) were included in this study. Multivariate analysis by Cox proportional-hazards (CPH) model was used to identify the prognostic indicators associated with the survival of COVID-19 inpatients.

Results: Of (460) COVID-19 positive patients, there were 133 (28.9%) deaths with mortality rate of 16.9 per 1000 person-days. Then, 97 (72.9%) deaths occurred within 21 days of symptom onset, with median survival time of 28 (95% CI: 25-36) days. The results of the CPH model showed that the abnormal chest X-ray (CXR) [aHR=3.8, 95% CI: (1.1, 12.6), p=0.032], SpO2 level below 92% [aHR=3.7, 95% CI: 2.3, 5.9, p<0.001)], serum creatinine level more than 133 µmol/L [aHR=1.9, 95% CI: 1.1, 3.2, p=0.025] and C-reactive protein level (CRP) more than 10 mg/L [aHR=3.9, 95% CI: 1.2, 12.9, p=0.027] were the prognostic indicators of COVID-19 death among inpatients in NYGH.

Conclusions: Patients with abnormal CXR result, low SpO2 level, high serum creatinine level, and high CRP level may have increased risks of death among COVID-19 inpatients in NYGH. Thus, close monitoring of the hospitalized COVID-19 inpatients by using these prognostic indicators should be emphasized.

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Published

2023-07-18

How to Cite

Htoo, T. S., Lwin, S. M. M., Aung, M. S., & Nwe, T. T. (2023). Survival analysis of hospitalized COVID-19 patients in New Yangon General Hospital by prognostic indicators. International Journal of Research in Medical Sciences, 11(8), 2766–2773. https://doi.org/10.18203/2320-6012.ijrms20232177

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Section

Original Research Articles