Mesoamerican nephropathy: a narrative review

Authors

  • Yugam R. Oza Department of Medicine, Grodno State Medical University, Grodno, Belarus
  • Anjali S. Mannava All India Institute of Medical Sciences, Chhattisgarh, India
  • Meirajuddin J. Tousif Khaja Bandawaz Institute of Medical Sciences, Karnataka, India
  • Jash K. Shah Department of Medicine, Grodno State Medical University, Grodno, Belarus
  • Shrinath V. Gondalia Department of Medicine, Grodno State Medical University, Grodno, Belarus
  • Hardik B. Mevawala Department of Medicine, Grodno State Medical University, Grodno, Belarus
  • Helly M. Joshi Department of Medicine, Grodno State Medical University, Grodno, Belarus
  • Nancy M. Gor Department of Medicine, Grodno State Medical University, Grodno, Belarus
  • Nishi J. Jivarani Department of Medicine, Grodno State Medical University, Grodno, Belarus
  • Dhruv U. Dharani Department of Medicine, Grodno State Medical University, Grodno, Belarus

DOI:

https://doi.org/10.18203/2320-6012.ijrms20232457

Keywords:

Mesoamerican nephropathy, Sugarcane farmers, Chronic kidney disease of unknown etiology, Narrative review, Heat, Dehydration

Abstract

Mesoamerican nephropathy (MeN) also known as chronic kidney disease of unknown etiology (CKDu) is prevalent in agriculturally rich areas. The most widely accepted pathophysiological explanation for MeN is chronic dehydration caused by prolonged exposure to the sun. Other theories include oxidative stress, chronic inflammation, infection and tubulointerstitial fibrosis. The clinical presentation is quite vague and is diagnosed similar to CKD from any cause using blood, urine analysis and ultrasound. The study highlights the need for interdisciplinary cooperation among physicians, epidemiologists, toxicologists, and geneticists while identifying significant research gaps and future objectives. Occupational health related to agriculture is not emphasised enough especially in third world countries where a large chunk of population heavily depend on farming. To safeguard the population at risk, the significance of community-based initiatives, occupational health measures, and regulatory changes is emphasised.

References

Wesseling C, Crowe J, Hogstedt C, Jakobsson K, Lucas R, Wegman DH, et al. Resolving the enigma of the mesoamerican nephropathy: a research workshop summary. Am J Kidney Dis. 2014;63(3):396-404.

Torres C, Aragón A, González M, López I, Jakobsson K, Elinder CG, et al. Decreased kidney function of unknown cause in Nicaragua: a community-based survey. Am J Kidney Dis. 2010;55(3):485-96.

Peraza S, Wesseling C, Aragon A, Leiva R, García-Trabanino RA, Torres C, et al. Decreased kidney function among agricultural workers in El Salvador. Am J Kidney Dis. 2012;59(4):531-40.

Johnson RJ, Sánchez-Lozada LG. Chronic kidney disease: Mesoamerican nephropathy--new clues to the cause. Nat Rev Nephrol. 2013;9(10):560-1.

Rotter R, García-Trabanino R. Mesoamerican Nephropathy. Semin Nephrol. 2019;39(3):263-71.

Ordunez P, Martinez R, Reveiz L, Chapman E, Saenz C, Soares da Silva A, et al. Chronic kidney disease epidemic in Central America: urgent public health action is needed amid causal uncertainty. PLoS Negl Trop Dis. 2014;8(8):e3019.

Diez G, Gonzalez-Bedat M, Ferreiro A, García-García G, Fernandez-Cean J, Douthat W. Burden of end-stage renal disease (ESRD) in Latin America. Clin Nephrol. 2016;86 (2016)(13):29-33.

Raines N, González M, Wyatt C, Kurzrok M, Pool C, Lemma T, et al. Risk factors for reduced glomerular filtration rate in a Nicaraguan community affected by Mesoamerican nephropathy. MEDICC Rev. 2014;16(2):16-22.

Trabanino RG, Aguilar R, Silva CR, Mercado MO, Merino RL. End-stage renal disease among patients in a referral hospital in El Salvador. Rev Panam Salud Publica. 2002;12(3):202-6.

Meda R, Alvarez-Elías AC, Bonilla-Félix M. Mesoamerican Endemic Nephropathy (MeN): A Disease Reported in Adults That May Start Since Childhood? Semin Nephrol. 2022;42(5):151337.

Rotter R, Wesseling C, Johnson RJ. CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy. Am J Kidney Dis. 2014;63(3):506-20.

Core Indicators. Health Trends in the Americas. Organización Panamericana de la Salud, 2019. Available at: https://iris.paho.org/handle/10665. Accessed on 10 June 2023.

Wesseling C, Glaser J, Rodríguez-Guzmán J, Weiss I, Lucas R, Peraza S, et al. Chronic kidney disease of non-traditional origin in Mesoamerica: a disease primarily driven by occupational heat stress. Rev Panam Salud Publica. 2020;44:e15.

Polo V, Garcia-Trabanino R, Rodriguez G, Madero M. Mesoamerican Nephropathy (MeN): What We Know so Far. Int J Nephrol Renovasc Dis. 2020;13:261-72.

Murray KO, Fischer RS, Chavarria D, Duttmann C, Garcia MN, Gorchakov R, et al. Mesoamerican nephropathy: a neglected tropical disease with an infectious etiology? Microbes Infect. 2015;17(10):671-5.

Murray KO, Fischer RS, Chavarria D, Duttmann C, Garcia MN, Gorchakov R, et al. Mesoamerican nephropathy: a neglected tropical disease with an infectious etiology? Microbes Infect. 2015;17(10):671-5.

Madero M, García-Arroyo FE, Sánchez-Lozada LG. Pathophysiologic insight into MesoAmerican nephropathy. Curr Opin Nephrol Hypertens. 2017;26(4):296-302.

Yang CW. Leptospirosis Renal Disease: Emerging Culprit of Chronic Kidney Disease Unknown Etiology. Nephron. 2018;138(2):129-36.

Fischer RSB, Vangala C, Mandayam S, Chavarria D, García-Trabanino R, et al. Clinical markers to predict progression from acute to chronic kidney disease in Mesoamerican nephropathy. Kidney Int. 2018;94(6):1205-16.

Fischer RSB, Mandayam S, Chavarria D, Vangala C, Nolan MS, Garcia LL, et al. Clinical Evidence of Acute Mesoamerican Nephropathy. Am J Trop Med Hyg. 2017;97(4):1247-56.

Fischer RSB, Vangala C, Truong L, Mandayam S, Chavarria D, Granera Llanes OM, et al. Early detection of acute tubulointerstitial nephritis in the genesis of Mesoamerican nephropathy. Kidney Int. 2018;93(3):681-90.

Anupama YJ, Sankarasubbaiyan S, Taduri G. Chronic Kidney Disease of Unknown Etiology: Case Definition for India - A Perspective. Indian J Nephrol. 2020;30(4):236-40.

Goraya N, Wesson DE. Clinical evidence that treatment of metabolic acidosis slows the progression of chronic kidney disease. Curr Opin Nephrol Hypertens. 2019;28(3):267-77.

Jimenez CA, Sato Y, Milagres T, Andres Hernando A, García G, Bjornstad P, et al. Experimental heat stress nephropathy and liver injury are improved by allopurinol. Am J Physiol Renal Physiol. 2018;315(3):F726-33.

Sanchez Polo V, Garcia-Trabanino R, Rodriguez G, Madero M. Mesoamerican Nephropathy (MeN): What We Know so Far. Int J Nephrol Renovasc Dis. 2020;13:261-72.

Iorio BR, Bellasi A, Raphael KL, Santoro D, Aucella F, Garofano L, et al. Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study. J Nephrol. 2019;32(6):989-1001.

Rotter R, García-Trabanino R. Mesoamerican Nephropathy. Semin Nephrol. 2019;39(3):263-71.

Chang KT, Lin HY. Chronic Kidney Disease of Unknown Cause in Agricultural Communities. N Engl J Med. 2019;381(7):688.

Trabanino R, Jarquín E, Wesseling C, Johnson RJ, González-Quiroz M, Weiss I, et al. Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador--A cross-shift study of workers at risk of Mesoamerican nephropathy. Environ Res. 2015;142:746-55.

olo V, Garcia-Trabanino R, Rodriguez G, Madero M. Mesoamerican Nephropathy (MeN): What We Know so Far. Int J Nephrol Renovasc Dis. 2020 Oct 22;13:261-72.

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Published

2023-07-29

How to Cite

Oza, Y. R., Mannava, A. S., Tousif, M. J., Shah, J. K., Gondalia, S. V., Mevawala, H. B., Joshi, H. M., Gor, N. M., Jivarani, N. J., & Dharani, D. U. (2023). Mesoamerican nephropathy: a narrative review. International Journal of Research in Medical Sciences, 11(8), 3100–3104. https://doi.org/10.18203/2320-6012.ijrms20232457

Issue

Vol. 11 No. 8 (2023): August 2023

Section

Review Articles