Association between elevated serum uric acid levels and islet beta cell function indices in newly diagnosed type 2 diabetes mellitus-a one year cross sectional study at tertiary care center

Kopal Gupta; Haritha P.; V. A. Kothiwale

doi:10.18203/2320-6012.ijrms20231784

Authors

Kopal Gupta Department of General Medicine, Shree Siddhi Vinayak Hospital, Bhilwara, Rajasthan, India
Haritha P. Department of General Medicine, Sri Ramachandra Medical College, Chennai, Tamil Nadu, India
V. A. Kothiwale Department of General Medicine, JN Medical College, Belagavi, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20231784

Keywords:

Newly diagnosed T2DM, SUA, Pancreatic islet β cell function, HOMA-IR

Abstract

Background: Serum uric acid (SUA) has been reported as a risk factor for type 2 diabetes mellitus (T2DM). Even though various studies concluded that SUA plays an essential role in DM onset, association between SUA and pancreatic islet β cell function and the effect of gender and body mass index (BMI) on it in is still unclear.

Methods: A hospital based one-year cross-sectional study was conducted and required data was collected from 76 patient who were newly diagnosed T2DM. All patients were investigated for SUA, and homeostasis model assessment-insulin resistance (HOMA-IR) was calculated using the HOMA2 calculator.

Results: Mean SUA level among the males was 4.65±1.81 mg/dl and among the females was 4.31±1.94 mg/dl. β pancreatic cell function index was estimated using HOMA-IR. Mean HOMA-IR level among the male study population was 5.01±7.44 and 5.02±4.63 among the females. A positive and significant correlation was observed between SUA and HOMA-IR (r=0.2283, p=0.0489) at 5% level, and was more pronounced among the female population (r=0.5127, p=0.0175). Correlation between HOMA-IR and BMI was found to be positive and significant (r=0.4948, p=0.0001). On plotting multiple regression analysis, coefficient of determination (R²) was 0.8374 (p<0.05), indicating significant contribution of all variables when combined towards HOMA-IR.

Conclusions: Present study demonstrates that SUA harbours a positive and significant correlation with pancreatic islet β cell function index among newly diagnosed T2DM patients and is influenced by gender and BMI.

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