Granulomatous reaction - a histopathological study: a retrospective and prospective study of 5 years

Khyati Ranchhodbhai Babaria, Amit H. Agravat, Gauravi A. Dhruva

Abstract


Background:The present study was done to investigate the prevalence of granulomatous infection among the patients. The study was conducted from the time period of July 2008 to June 2013. The study was conducted at the histopathology laboratory, pathology department, P. D. U. government medical college, Rajkot (Gujarat, India).

Methods:In the present study, total 300 cases were studied. Specimens for study were received from various departments like surgery, ENT, medicine, pediatrics etc. from July 2008 to June 2013. The sections of these specimens were taken & slides were prepared by staining with Hematoxylin & Eosin (H&E) for microscopic examination.

Results: In present study, most the common granulomatous reaction was tuberculosis and majority of cases were found in among young Hindu males specially in the lower socioeconomical class of rural areas.

Conclusion:Our study confirms that the most common granulomatous reaction is tuberculosis, mainly found in skin and more common among the population of lower socioeconomic class & rural population, signifying increasing incidence of granulomation infection. The present study is a comprehensive comparative study of granulomatous reactions done in correlation with the age, sex, involved sites and clinical profile of the patients. This information is valuable in policy formation for the control & specific treatment and outcome of granulomatous infection.

 


Keywords


Histopathological, Granulomatous, P. D. U. government

Full Text:

PDF

References


Adams DO. The granulomatous inflammatory response. Am J Pathol. 1976;84:164-87.

Long ER. Granulomatous inflammation. In: Long ER, eds. A History of Pathology. 1st ed. New York: Dover Publications, Inc.; 1965.

Vinay Kumar, Abul K. Abbas, Jon C. Aster. Granulomatous inflammation. In: Robbins S. Cottran, eds. 9th ed. The Pathological Basis of Disease. Philadelphia: Saunders; 2014: 70-76.

Harish S. Permi, Jayaprakash Shetty K, Shetty K. Padma, Teerthanath S, Michelle Mathias, Sunil Kumar Y, et al. A histopathological study of granulomatous inflammation: Nitte Univ J Health Sci. 2012;2:15-9.

Geraint. T. Williams, Jones W. Williams. Granulomatous inflammation: a review. J Clin Pathol. 1983;36:723-33.

Blessing K. Mini-symposium: inflammatory skin pathology: cutaneous granulomatous inflammation. Curr Diagn Pathol. 2005;11:219-35.

Dhar S. Histopathological features of granulomatous skin diseases, analysis of 22 skin biopsies. Indian J Dermatol. 2002;47:88-90.

Jayashree Pawal, Rekha Puranik, M. H. Kulkarni. A histopathological study of granulomatous inflammations with an attempt to find the aetiology. J Clin Diagn Res. 2011 Apr;5(2):301-6.

Gautam K, Pai RR, Bhat S. Granulomatous lesions of the skin. J Pathol Nepal. 2011;1:81-6.

Zafar MNU, Sadiq S, Menon MA. Morphological study of different granulomatous lesions of the skin. J Pak Assoc Dermatol. 2008;18:21-8.

Krishnaswamy H, Job CK. The role of Ziehl Neelson and Fluorescent stains in tissue sections in the diagnosis of tuberculosis. Indian J Tubercul. 1974 Jan;21(10):18-21.

Jayalakshmi P, Path MRC, Malik AK. Histopathology of lymph nodal tuberculosis: University hospital experience Malaysian. I Pathol. 1994;16(1):43-7.