Correlation of lipoprotein (a) level with severity of coronary lesion in coronary heart disease patients

M. Sawkat Hossan; Prabir Kumar Das; Saurav Das; Partha Bhattacharyya; Khondaker M. Ismail; Iqbal Mahmud; Syed Miskatun Nur; M. Najim Uddin; Abu Sayem Mohammad Omar Faroque; M. Emran Hossain

doi:10.18203/2320-6012.ijrms20232508

Authors

M. Sawkat Hossan OSD (DGHS), Deputed to Chittagong Medical College, Chittagong Medical College, Chattogram, Bangladesh
Prabir Kumar Das Department of Cardiology, Chittagong Medical College, Chattogram, Bangladesh
Saurav Das OSD (DGHS), Deputed to Chittagong Medical College, Chittagong Medical College, Chattogram, Bangladesh
Partha Bhattacharyya OSD (DGHS), Deputed to Chittagong Medical College, Chittagong Medical College, Chattogram, Bangladesh
Khondaker M. Ismail OSD (DGHS), Deputed to Chittagong Medical College, Chittagong Medical College, Chattogram, Bangladesh
Iqbal Mahmud OSD (DGHS), Deputed to Chittagong Medical College, Chittagong Medical College, Chattogram, Bangladesh
Syed Miskatun Nur OSD (DGHS), Deputed to Chittagong Medical College, Chittagong Medical College, Chattogram, Bangladesh
M. Najim Uddin Department of Cardiology, Chittagong Medical College, Chattogram, Bangladesh
Abu Sayem Mohammad Omar Faroque OSD (DGHS), Deputed to Chittagong Medical College, Chittagong Medical College, Chattogram, Bangladesh
M. Emran Hossain Department of Cardiology, Chittagong Medical College, Chattogram, Bangladesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20232508

Keywords:

CHD, CVD, Lipoprotein, Risk factors

Abstract

Background: Cardiovascular diseases (CVDs) are the leading cause of death in developing nations, especially in low and middle-income countries (LMICs). Bangladesh has been undergoing an epidemiological transition from communicable to non-communicable diseases. This study aimed to investigate the association of risk factors with coronary heart disease (CHD) in patients from Bangladesh.

Methods: This cross-sectional observational study was conducted in the department of cardiology, Chattogram Medical College and Hospital, Chattogram, Bangladesh from July 2018 to June 2019. A total of 100 patients were enrolled.

Results: This cross-sectional study enrolled 100 CHD patients with a mean age of 53.21±10.29 years. The majority were obese (64, 64.0%), and hypertension was the most prevalent risk factor (77, 77.0%), followed by smoking (65, 65.0%) and dyslipidemia (58, 58.0%). Most patients had triple vessel disease (53, 53.0%), and significant CHD (81, 81.0%). Patients with severe CHD had higher levels of blood LDL-C, triglycerides, and Lp(a). Lp(a) levels, history of dyslipidemia, and LDL-C were independently associated with a Gensini score ≥20. These findings emphasize the independent association between Lp(a) and CHD severity, warranting greater attention to patients with elevated Lp(a) levels.

Conclusions: This study suggested that Lp(a) is an independent risk factor for CHD in patients from Bangladesh. More attention should be paid to such patients with elevated Lp(a) level.

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