Hepatitis B virus infection and ABO/Rh blood groups
DOI:
https://doi.org/10.18203/2320-6012.ijrms20173949Keywords:
ABO blood group, Hepatitis B virus, Rh blood groupAbstract
Background: Chronic HBV infection is a significant public health problem all around the world. It is not clear if ABO/Rh blood groups have a role in the development of chronic forms of hepatitis B virus (HBV) infection. The aim of the study was to investigate the relationship between chronic HBV infection and ABO/Rh blood groups.
Methods: The study was designed as a retrospective study that included totaled 937 individuals: 453 patients diagnosed with chronic hepatitis and 484 healthy individuals as the control group. HBsAg (hepatitis B surface antigen) and blood groups results of patients between the years 2013-2015 were collected by reviewing the laboratory results. During these three years HBsAg was performed on the architect i2000sr (Abbott diagnostic, Illinois, USA) with ELISA and ABO/Rh blood groups were analyzed with gel centrifugation method (Grifols, Barcelona, Spain).
Results: Blood group A Rh positive was higher than other blood types in the chronic hepatitis B group (44.3%) and in control group (41.9%), whereas blood types O, AB, and B were similar between cases with chronic hepatitis and controls (p>0.05). HBV infection was moderately less frequent in subjects with AB positive blood group (p=0.07). The prevalence of Rh positive was 89.1% in patients and 88.2% in the control group (p>0.05).
Conclusions: This study showed that there was not an association between ABO/Rh blood groups and chronic HBV infection, but there is a need for different and more numerous case-control studies about this subject.
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