Autoimmune/inflammatory syndrome induced by adjuvants: a review

Authors

  • Víctor M. Bueno-Gardea Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • José H. Baeza-Ramos Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • Omar A. Avalos-Trejo Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • Ana G. Durán-Rodríguez Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • José R. Martínez-Acosta Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • Mariana Baeza-Salcido Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • Irving A. Aponte de la Rosa Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • Marcos Muñoz-Torres Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • María F. Abbud-Fitzmaurice Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico
  • Nicolás R. Brito-Brito Department of General Surgery, General Hospital of Mexico, Dr. Eduardo Liceaga, CDMX, Mexico
  • Baltazar Barrera-Mera Department of Physiology, UNAM, Mexico
  • Alan Isaac Valderrama-Treviño Department of Angiology, Vascular and Endovascular Surgery, General Hospital of Mexico, “Dr. Eduardo Liceaga”, CDMX, Mexico
  • José A. Velasco-Cabrera Department of Plastic Surgery, Central University Hospital, Dr. Jesús Enrique Grajeda Herrera, Chihuahua, Mexico

DOI:

https://doi.org/10.18203/2320-6012.ijrms20232458

Keywords:

Autoimmune/inflammatory syndrome induced by adjuvants, Medical devices, Autoimmunity, Breast implants, Silicone breast implantation

Abstract

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) includes several autoimmune conditions and phenomena that occur after exposure to substances with adjuvant activity. The spectrum of the disease is heterogeneous with respect to the clinical presentation as well as the severity of the clinical manifestations. Different substances and medical devices with adjuvant activity are currently known, such as vaccines, oils, silicones, mineral salts, lipopolysaccharides, peptidoglycans, among others. These adjuvants are immunological molecules that function through potentiation of antigen-specific immune responses. Thus, the etiopathogenesis of ASIA syndrome involves a multifactorial interaction between environmental factors and genetic predisposition, and secondary activation of the adaptive and innate arms of the immune system through various mechanisms. Although in some reported cases the ASIA syndrome improves considerably when removing the implants, there are no conclusive results for the clinical benefit of removing the implants, so it is necessary to carry out further basic, clinical and surgical investigations in order to determine the best therapeutic decision.

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References

Cohen Tervaert JW, Mohazab N, Redmond D, van Eeden C, Osman M. Breast implant illness: scientific evidence of its existence. Expert Rev Clin Immunol. 2022;18(1):15-29.

Cohen Tervaert JW, Colaris MJ, van der Hulst RR. Silicone breast implants and autoimmune rheumatic diseases: myth or reality. Curr Opin Rheumatol. 2017;29(4):348-54.

Shoenfeld Y, Agmon-Levin N. ‘ASIA’-autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011;36:4-8.

Coffman R, Sher A, Seder R. Vaccine adjuvants: putting innate immunity to work. Immunity. 2010;33(4):492-503.

Ruiz JT, Lujan L, Blank M, Shoenfeld Y. Adjuvants-and vaccines-induced autoimmunity: animal models. Immunol Res. 2017;65(1):55-65.

Cohen Tervaert JW. Autoinflammatory/ autoimmunity syndrome induced by adjuvants (Shoenfeld’s syndrome) in patients after a polypropylene mesh implantation. Best Pract Res Clin Rheumatol. 2018;32(4):511-20.

Chauhan U, Cassidy B, Cohen Tervaert JW. ASIA (Shoenfeld’s syndrome) due to hysteroscopic Essure sterilization. Autoimmun Rev. 2021;20(12):102979.

Cohen Tervaert JW, Martinez-Lavin M, Jara LJ, Halpert G, Watad A, Amital H, et al. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023. Autoimmun Rev. 2023;22(5):103287.

Major MR, Wong VW, Nelson ER, Longaker MT, Gurtner GC. The foreign body response: at the interface of surgery and bioengineering. Plast Reconstr Surg. 2015;135(5):1489-98.

Nolfi AL, Brown BN, Liang R, Palcsey SL, Bonidie MJ, Abramowitch SD, et al. Host response to synthetic mesh in women with mesh complications. Am J Obstet Gynecol. 2016;215(2):206.e1-8.

Zdolsek J, Eaton JW, Tang L. Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans. J Transl Med. 2007;5:31.

Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-Goton V, Alpizar YA, et al. Histamine receptor H1-mediated sensitization of TRPV1 mediates visceral hypersensitivity and symptoms in patients with irritable bowel syndrome. Gastroenterology. 2016;150(4):875-87.

Bizjak M, Selmi C, Praprotnik S, Bruck O, Perricone C, Ehrenfeld M, et al. Silicone implants and lymphoma: the role of inflammation. J Autoimmun. 2015;65:64-73.

Wolfram D, Rabensteiner E, Grundtman C, Bock G, Mayerl C, Parson W, et al. T regulatory cells and TH17 cells in perisilicone implant capsular fibrosis. Plast Reconstr Surg. 2012;129(2):327e-37.

Kadin ME, Morgan J, Xu H, Epstein AL, Sieber D, Hubbard BA, et al. IL-13 is produced by tumor cells in breast implant associated anaplastic large cell lymphoma: implications for pathogenesis. Hum Pathol. 2018;78:54-62.

Tamboto H, Vickery K, Deva AK. Subclinical (biofilm) infection causes capsular contracture in a porcine model following augmentation mammaplasty. Plast Reconstr Surg. 2010;126(3):835-42.

Caravantes-Cortes MI, Roldan-Valadez E, Zwojewski-Martinez RD, Salazar-Ruiz SY, Carballo-Zarate AA. Breast Prosthesis Syndrome: Pathophysiology and Management Algorithm. Aesth Plast Surg. 2020;44:1423-37.

Sandoval P, Pardo S, Arenas L, Fonseca C, Gonzales C, Rueda H. ASIA syndrome, an unknown pathology. RCCP. 2022;28(1):42-8.

Vaz R, Xavier P, Brito S, Dantas J, Duque S, Consciência JG, et al. Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? Eur J Case Rep Intern Med. 2019;6(3):001034.

Montealegre G, Uribe R, Martínez-Ceballos MA, Rojas-Vi- llarraga A. ASIA syndrome symptoms induced by gluteal biopolymer injections: Case-series and narrative review. Toxicol Rep. 2021;8:303-4.

Rojas-Villarraga A. Silicone implants, biopolymers and autoimmunity: facts and controversies. Cir Plást Iberolatinoam. 2022;48(2):119-22.

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Published

2023-07-29

How to Cite

Bueno-Gardea, V. M., Baeza-Ramos, J. H., Avalos-Trejo, O. A., Durán-Rodríguez, A. G., Martínez-Acosta, J. R., Baeza-Salcido, M., Rosa, I. A. A. de la, Muñoz-Torres, M., Abbud-Fitzmaurice, M. F., Brito-Brito, N. R., Barrera-Mera, B., Valderrama-Treviño, A. I., & Velasco-Cabrera , J. A. (2023). Autoimmune/inflammatory syndrome induced by adjuvants: a review. International Journal of Research in Medical Sciences, 11(8), 3105–3109. https://doi.org/10.18203/2320-6012.ijrms20232458

Issue

Vol. 11 No. 8 (2023): August 2023

Section

Review Articles
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