Efficacy and safety of SilverNovaTM skin cream as adjuvant to oral and topical antifungals in treatment of fungal skin infections


  • Abhay Talathi Skin Space Clinic, Mumbai, Maharashtra, India
  • Avinash Jadhav Jyoti Multispecialty Clinic, Pune, Maharashtra, India
  • Sanjay Purohit Maven’s Hospital, Ajmer, Rajasthan, India
  • Anirudh Mehta Viridis BioPharma Pvt. Ltd. Mumbai, Maharashtra, India




AgNPs, SilverSol® technology, Dermatophyte, Intertrigo, Seborrheic dermatitis, Silver nanoparticles, Tinea infections


Background: To evaluate the efficacy and safety of SilverNovaTM skin cream, composed of SilverSol® (a patented colloidal nano silver technology from American Biotech Labs, USA) with other skin rejuvenators (coconut oil, vitamin E, and hyaluronic acid), as an adjuvant to topical and oral antifungals in the treatment of fungal skin infections like tinea and intertrigo.

Methods: This prospective clinical study enrolled 80 patients with tinea corporis, tinea cruris, tinea manus, tinea pedis infections, and intertrigo. The patients were randomized to receive either SilverNovaTM skin cream and clotrimazole cream (n=40) or clotrimazole cream (n=40) alone applied topically as an adjuvant to oral antifungal therapy for 14 days. The primary endpoints were the reduction of clinical signs and symptoms of the infection at the end of the treatment and the proportion of patients with therapeutic cures.

Results: SilverNovaTM skin cream exhibited better efficacy and safety than clotrimazole cream, though without reaching clinical significance at the end of the treatment. On the 14th day, there was an improvement in clinical signs and symptoms of fissuring/cracking, erythema, maceration, scaling, pruritus, and burning/stinging from baseline in patients with tinea infections, and intertrigo in both the treatment groups. A higher proportion of patients reported therapeutic cures at the end of the treatment, numerically better with SilverNovaTM skin cream group. No drug-related adverse events occurred.

Conclusions: SilverNovaTM skin cream is effective and well tolerated as an adjuvant to topical and oral antifungals for the treatment of fungal skin infections like tinea and intertrigo.


Gunaydin SD, Arikan-Akdagli S, Akova M. Fungal infections of the skin and soft tissue. Curr Opin Infect Dis. 2020;33(2):130-6.

Kaushik N, Pujalte GGA, Reese ST. Superficial Fungal Infections. Prim Care. 2015;42(4):501-16.

Rónavári A, Igaz N, Gopisetty MK, Szerencsés B, Kovács D, Papp C, et al. Biosynthesized silver and gold nanoparticles are potent antimycotics against opportunistic pathogenic yeasts and dermatophytes. Int J Nanomed. 2018;13:695-703.

Kovitwanichkanont T, Chong AH. Superficial fungal infections. Aust J Gen Pract. 2019;48(10):706-11.

Taudorf EH, Jemec GBE, Hay RJ, Saunte DML. Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. J Eur Acad Dermatol Venereol. 2019;33(10):1863-73.

Metin A, Dilek N, Bilgili SG. Recurrent candidal intertrigo: challenges and solutions. Clin Cosmet Investig Dermatol. 2018;11:175-85.

Kalra MG, Higgins KE, Kinney BS. Intertrigo and secondary skin infections. Am Fam Physician. 2014;89(7):569-73.

Janniger CK, Schwartz RA, Szepietowski JC, Reich A. Intertrigo and common secondary skin infections. Am Fam Physician. 2005;72(5):833-8.

Thomas LM, Khasraghi AH. Nanotechnology-Based Topical Drug Delivery Systems for Management of Dandruff and Seborrheic Dermatitis: An overview. Iraqi J Pharm Sci. 2020;29(1):12-32.

Lakshmanan A, Ganeshkumar P, Mohan SR, Hemamalini M, Madhavan R. Epidemiological and clinical pattern of dermatomycoses in rural India. Indian J Med Microbiol. 2015;33 Suppl:134-6.

Verma S, Madhu R. The Great Indian Epidemic of Superficial Dermatophytosis: An Appraisal. Indian J Dermatol. 2017;62(3):227-36.

Tahiliani S, Saraswat A, Lahiri AK, Shah A, Hawelia D, Shah GK, et al. Etiological prevalence and antifungal sensitivity patterns of dermatophytosis in India – A multicentric study. Indian J Dermatol Venereol Leprol. 2021;87:800-6.

Abdallah BM, Rajendran P, Ali EM. Potential Treatment of Dermatophyte Trichophyton rubrum in Rat Model Using Topical Green Biosynthesized Silver Nanoparticles with Achillea santolina Extract. Molecules. 2023;28(4):1536.

Singh SB, Young K, Silver LL. What is an “ideal” antibiotic? Discovery challenges and path forward. Biochem Pharmacol. 2017;133:63-73.

Bhargava P, Nijhawan S, Singdia H, Mehta T. Skin Barrier Function Defect - A Marker of Recalcitrant Tinea Infections. Indian Dermatol Online J. 2020;11(4):566-9.

Hube B, Hay R, Brasch J, Veraldi S, Schaller M. Dermatomycoses and inflammation: The adaptive balance between growth, damage, and survival. J de Mycologie Médicale. 2015;25(1):e44- 58.

Gupta AK, Foley KA, Versteeg SG. New antifungal agents and new formulations against dermatophytes. Mycopathologia. 2017;182(1-2):127-41.

Sitepu EH, Muis K, Putra IB. Dermatophytes and bacterial superinfections in tinea pedis patients at Haji Adam Malik Central Hospital, Medan-Indonesia. Bali Med J. 2018;7(2):452-6.

Rengasamy M, Shenoy MM, Dogra S, Asokan N, Khurana A, Poojary S, et al. Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) Task Force against Recalcitrant Tinea (ITART) Consensus on the Management of Glabrous Tinea (INTACT). Indian Dermatol Online J. 2020;11(4):502-19.

Mussin JE, Roldán MV, Rojas F, de Los Ángeles Sosa M, Pellegri N, Giusiano G. Antifungal activity of silver nanoparticles in combination with ketoconazole against Malassezia furfur. AMB Express. 2019;9(1):131.

Agarwal H, Nakara A, Shanmugam VK. Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review. Biomed Pharmacother. 2019;109:2561-72.

Tripathy S. Rising prevalence of dermatophytosis in India: A matter of concern. Int J Infect Dis. 2016;45:318.

Howard SJ, Cerar D, Anderson MJ, Albarrag A, Fisher MC, Pasqualotto AC, et al. Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis. 2009;15(7):1068-76.

Ouf SA, Mohamed AAH, El-Adly AA. Enhancement of the antidermatophytic activity of silver nanoparticles by Q-switched Nd:YAG laser and monoclonal antibody conjugation. Med Mycol. 2017;55(5):495-506.

Brewer AC, Huber JT, Girardo ME, Kosiorek HE, Burns MW, Stewart TD, et al. Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis. Int J Dermatol. 2019;58(2):250-3.

Talapko J, Matijević T, Juzbašić M, Antolović-Požgain A, Škrlec I. Antibacterial Activity of Silver and Its Application in Dentistry, Cardiology and Dermatology. Microorganisms. 2020;8(9):1400.

Singh A, Masih A, Monroy-Nieto J, Singh PK, Bowers J, Travis J, et al. A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/ Trichophyton interdigitale complex causing an ongoing alarming dermatophytosis outbreak in India: Genomic insights and resistance profile. Fungal Genet Biol. 2019;133:103266.

De Souza A, Mehta D, Leavitt RW. Bactericidal activity of combinations of silver–water dispersion with 19 antibiotics against seven microbial strains. Curr. Sci. 2006;91:926-9.

Pirtarighat S, Ghannadnia M, Baghshahi S. Green synthesis of silver nanoparticles using the plant extract of Salvia spinosa grown in vitro and their antibacterial activity assessment. J Nanostructure Chem. 2019;9(1):1-9.

Soni A, Kumar A, Kumar A, Choudhary A, Happy. New Era of Formulation as Silver Nanoparticles in Pharma. J Drug Deliv Ther. 2021;11(2-S):126-31.

El-Badry A, Assawah S, El-Kassas H, Hegab D, Amer D. New Remedy to Control Human Skin Fungal Infections by Silver Nanoparticles Biosynthesized by Two Marine Macro Algae. Egypt J Bot. 2019;49(2):493-511.

Kim KJ, Sung WS, Suh BK, Moon SK, Choi JS, Kim JG, et al. Antifungal activity and mode of action of silver nano- particles on Candida albicans. Biometals Int J Role Met Ions Biol Biochem Med. 2009;22(2):235-42.

Ayatollahi Mousavi SA, Salari S, Hadizadeh S. Evaluation of Antifungal Effect of Silver Nanoparticles Against Microsporum canis, Trichophyton mentagrophytes and Microsporum gypseum. Iran J Biotechnol. 2016;13(4):38-42.

Panja A, Mishra AK, Dash M, Pandey NK, Singh SK, Kumar B. Silver Nanoparticles – A Review. Eurasian J Med Oncol. 2021;5(2):95-102

Kim KJ, Sung WS, Moon SK, Choi JS, Kim JG, Lee DG. Antifungal effect of silver nanoparticles on dermatophytes. J Microbiol Biotechnol. 2008;18(8):1482-4.

Xia ZK, Ma QH, Li SY, Zhang DQ, Cong L, Tian YL, et al. The antifungal effect of silver nanoparticles on Trichosporon asahii. J Microbiol Immunol Infect. 2016;49(2):182-8.

Noorbakhsh F, Rezaie S, Shahverdi A. Antifungal Effects of Silver Nanoparticle alone and with Combination of Antifungal Drug on Dermatophyte Pathogen Trichophyton Rubrum. 2011;5:364-7.

Gajera G, Godse C, DeSouza A, Mehta D, Kothari V. Potent anthelmintic activity of a colloidal nano- silver formulation (Silversol®) against the model worm Caenorhabditis elegans. BMC Res Notes. 2023;16(1):130.

Tran PL, Luth K, Wang J, Ray C, de Souza A, Mehta D, et al. Efficacy of a silver colloidal gel against selected oral bacteria in vitro. F1000Res. 2019 Mar 7;8:267.

Tran P, Kopel J, Luth K, Dong H, Dev A, Mehta D, et al. The in vitro efficacy of betadine antiseptic solution and colloidal silver gel combination in inhibiting the growth of bacterial biofilms. Am J Infect Control. 2023;51(1):23-28.

Mahale S, Walvekar A, Tiwari S, et al. Efficacy of Colloidal Nano Silver Tooth Gel in the Management of Oro-Dental Conditions: A Prospective, Randomized, Triple Arm, Parallel, Double Blind Controlled Interventional Clinical Study. J Oral Health Comm Dent. 2023. (Accepted for publication).

Ong WTJ, Nyam KL. Evaluation of silver nanoparticles in cosmeceutical and potential biosafety complications. Saudi J Biol Sci. 2022;29(4):2085-94.

Kuruwa M, Pathak H, Mehta A, Jadhav SS. An open labeled multicentric pilot trial to study the safety and efficacy of colloidal nano silver skin cream in patients with various skin diseases. Biomed J Sci Tech Res. 2022;46(1):37040-48.

Mistiaen P, Poot E, Hickox S, Wagner C. Preventing and treating intertrigo in the large skin folds of adults: a literature overview. Dermatol Nurs. 2004;16(1):43-6,49-57.

Urban K, Chu S, Scheufele C, Giesey RL, Mehrmal S, Uppal P, et al. The global, regional, and national burden of fungal skin diseases in 195 countries and territories: A cross-sectional analysis from the Global Burden of Disease Study 2017. JAAD Int. 2020;2:22-7.

Gajbhiye S, Sakharwade S. Silver Nanoparticles in Cosmetics. J Cosmet Dermatol Sci Appl. 2016;06(01):48-53.

Pedersen G and Hegde BM. Silver Sol Completely Removes Malaria Parasites from the Blood of Human Subjects Infected with Malaria in an Average of Five Days: A Review of Four Randomized, Multi-Centered, Clinical Studies Performed in Africa. The Indian Practitioner. 2010;63(9):567-74.

De Souza A, Vora AH, Mehta AD, Moeller K. SilverSol® a Nano-Silver Preparation: A Multidimensional Approach to Advanced Wound Healing. In: (Eds.: Kumar P, Kothari V), Wound Healing Research, Springer. 2021:355-96.

Mihai MM, Dima MB, Dima B, Holban AM. Nanomaterials for Wound Healing and Infection Control. Materials. 2019;12(13):2176.

George R, Merten S, Wang TT, Kennedy P, Maitz P. In vivo analysis of dermal and systemic absorption of silver nanoparticles through healthy human skin. Australas J Dermatol. 2014;55(3):185-90.

Varma SR, Sivaprakasam TO, Arumugam I, Dilip N, Raghuraman M, Pavan KB, et al. In vitro anti-inflammatory and skin protective properties of Virgin coconut oil. J Tradit Complement Med. 2019;9(1):5-14.

Keen MA, Hassan I. Vitamin E in dermatology. Indian Dermatol Online J. 2016;7(4):311-5.

Dovedytis M, Liu ZJ, Bartlett S. Hyaluronic acid and its biomedical applications: A review. Eng Regen. 2020;1:102-13.




How to Cite

Talathi, A., Jadhav, A., Purohit, S., & Mehta, A. (2023). Efficacy and safety of SilverNovaTM skin cream as adjuvant to oral and topical antifungals in treatment of fungal skin infections. International Journal of Research in Medical Sciences, 11(9), 3376–3386. https://doi.org/10.18203/2320-6012.ijrms20232796



Original Research Articles