Effect of letrozole 2.5 mg or 5.0 mg for ovulation induction in intrauterine insemination in case of unexplained infertility: a randomized controlled trial

Neha Goel; Ashok Verma; Shubham Bansal; Manjeet Kumari; Drishti; Deeksha

doi:10.18203/2320-6012.ijrms20233022

Authors

Neha Goel Department of Obstetrics and Gynaecology, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India
Ashok Verma Department of Obstetrics and Gynaecology, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India
Shubham Bansal Department of Paediatrics, Maulana Azad Medical College, New Delhi, India
Manjeet Kumari Department of Obstetrics and Gynaecology, Mahatma Gandhi Memorial Medical College and Hospital, Jamshedpur, Jharkhand, India
Drishti Department of Obstetrics and Gynaecology, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India
Deeksha Department of Obstetrics and Gynaecology, Dr Rajendra Prasad Government Medical College, Kangra, Himachal Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20233022

Keywords:

Letrozole, Unexplained infertility, Intrauterine insemination

Abstract

Background: Aim was to compare effects of letrozole 2.5 mg or 5.0 mg for ovulation induction in patients with unexplained Infertility.

Methods: A randomized controlled trial. 60 patients attending infertility clinic were randomly allocated into two groups-Group A received letrozole 2.5 mg and Group B received letrozole 5 mg orally for 5 days from 3^rd day of cycle. The patients also received inj FSH 75 IU i/m on day 7 and 9 of the cycle and underwent follicular study on day 11, 13, 15. When the dominant follicle size reached 18 mm ovulation triggered with Inj hCG 5000 IU IM and Intrauterine insemination was done 24-36 hours later. Pregnancy rates were calculated. Results were analysed by statistical software.

Results: Better ovulation rates were seen in patients receiving 5 mg letrozole. No difference in the pregnancy rates was found between the two groups. No multiple pregnancies and ovarian hyperstimulation seen.

Conclusions: It appears that 5 mg daily for 5 days is a preferable letrozole dose for superovulation.

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