Post kidney transplant infections with special reference to cytomegalovirus

Jai Prakash Tiwari; Prashanth B.; Vinay Kumar A. V.

doi:10.18203/2320-6012.ijrms20233017

Authors

Jai Prakash Tiwari Department of Nephrology, Goa Medical College, Goa, India
Prashanth B. Department of Geriatric Medicine, Goa Medical College, Goa, India
Vinay Kumar A. V. Department of Nephrology, AIIMS Raipur, Chhattisgarh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20233017

Keywords:

Infections, Cytomegalovirus, Post kidney transplant, Tuberculosis

Abstract

Background: The burden of infectious disease is high among kidney transplant recipients because of concomitant immunosuppression.

Methods: Study was a retrospective and prospective cohort study. The study was conducted for a period of 12 months and 30 transplant recipients were included.

Results: Males comprised 86.66% of the study population. The mean age of the recipients was 37.96 years. UTI was the most common post-transplant infection observed in 15 patients (50%) of 30 patients. E. Coli infection was most predominant (50%) causing UTI. 5 patients (16.66%) in this study developed tuberculosis after renal transplantation. Two patients (6.66%) developed CMV infection in the study. Two patients (6.66%) developed COVID-19 infection in the study. Two patients (6.66%) developed herpes infection post-transplant. One patient (3.33%) in the study developed cryptococcal meningitis. One patient (3.33%) developed hepatitis C after 18 years of transplant. One patient (3.33%) developed hepatitis B after 10 years of transplant. Three patients (10%) developed lower respiratory tract infection and developed acute respiratory distress. Three patients (10%) had developed acute graft rejection within first year after transplantation. There are total of 13 deaths (43.33%) among 30 patients all of which were secondary to infections. Total of 4 patients among the 13 deaths had chronic graft rejection. Most common cause of death was tuberculosis (38.46%) followed by UTI (23%) and Lower respiratory tract infection (23%).

Conclusions: The incidence of infections is relatively higher in kidney transplant recipients when compared to general populations due to immunosuppression.

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