Evaluation of difference in central corneal thickness between premenopausal and postmenopausal women

Authors

  • Neharika Verma Department of Ophthalmology, Government Medical College, Jammu, Jammu and Kashmir, India
  • Palak Gupta Department of Ophthalmology, Government Medical College, Jammu, Jammu and Kashmir, India
  • Ashok Sharma Department of Ophthalmology, Government Medical College, Jammu, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20232777

Keywords:

Post menopausal women, Central corneal thickness, Pre menopausal women

Abstract

Background: Menopause is defined as permanent cessation of menses. By convention the diagnosis of menopause is not made until the individual has had 12 months of amenorrhoea. It is a physiological condition, and associated with changes in levels of sex hormones. Certain changes occur in the corneal tissue due to change in these hormones. The current study intended to study any change in central corneal thickness among women after menopause. CCT can cause false readings in IOP measurements and affect the diagnosis and monitoring of glaucoma.

Methods: It is a prospective, cross sectional, observational, case control study conducted in Department of Ophthalmology, GMC, Jammu for a period of 6 months from October 2022 to March 2023. 54 eyes of 27 patients each for pre and postmenopausal women were taken. Central corneal thickness was measured using specular biomicroscopy.

Results: The mean age of post-menopausal women was found to be 52±2 years and pre-menopausal women was found to be 48±3. The mean of group 1 was found to be 524±18.67 microns and the mean of group 2 was found to 558±20.83 microns

Conclusions: The data presented in this study suggest that menopause cause decrease in central corneal thickness.

References

Utian WH. The International Menopause menopause-related terminology definitions. Climacteric. 1999; 2(4):284-6.

Menopausal Transition. In: Hoffman BL, Schorge JO, Bradshaw KD, Halvorson LM, Schaffer JI, Corton MM, eds. Williams Gynecology. 3rd ed. USA: McGraw Hill; 2016.

Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA. Identification of androgen, estrogen and progesterone receptor mRNAs in the eye. Acta Ophthalmol. 2000;78:146-53.

Turgut FG, Turgut A, Dolgun ZN, Köroğlu N. Effects of menopause on corneal topography and dry eye. Int J Reprod Contracept Obstet Gyneco. 2017;6:461-5.

Aydin E, Demir HD, Demirturk F, Caliskan AC, Aytan H, Erkorkmaz U. Corneal topographic changes in premenopausal and postmenopausal women. BMC Ophthalmol. 2007;7:9.

Sanchis-Gimeno JA, Lleó-Pérez A, Alonso L, Rahhal MS, Martínez-Soriano F. Reduced corneal thickness values in postmenopausal women with dry eye. Cornea. 2005;24(1):39-44.

Leach NE, Wallis NE, Lothringer LL, Olson JA. Corneal hydration changes during the normal menstrual cycle a preliminary study. J Reprod Med. 1971;6:201-4.

Aydin E, Demir HD, Demirturk F, Caliskan AC, Aytan H, Erkorkmaz U. Corneal topographic changes in premenopausal and postmenopausal women. BMC Ophthalmol. 2007;7:9.

Suzuki T, Kinoshita Y, Tachibana M, Matsushima Y, Kobayashi Y, Adachi W et al., Expression of sex steroid hormone receptors in human cornea. Curr Eye Res. 2001;22:28-33.

Whitacre MM, Stein RA, Hassanein K. The effect of corneal thickness on applanation tonometry. Am J Ophthalmol. 1993;115(5):592-6.

Giuffre G, Caronia C, Lodato G. Variations in central corneal thickness during the menstrual cycle in women. Cornea. 2007;26:144-6.

McKay TB, Priyadarsini S, Karamichos D. Sex Hormones, Growth Hormone, and the Cornea. Cells. 2022;11(2):224.

Keskin N, Canturk S, Aydin S, Saygili H, Ozgun C. An objective method to determine corneal changes during menopause. Clin Exp Obstet Gynecol. 2009; 36(3):176-8.

Sharma R, Soni SS, Anupama B, Hegde V, Jain R, Akshaya KM. Do postmenopausal women have thinner central corneal thickness as compared to women in reproductive age group? Int J Sci Res. 2016;5(3):2188-91.

Ghahfarokhi NA, Vaseghi A, Ghahfarokhi NA, Ghoreishi M, Peyman A, Dehghani A. Evaluation of corneal thickness alterations during the menstrual cycle in productive age women. Indian J Ophthalmol. 2015;63(1):30-2.

Birgul R, Turan G. Comparison of changes in eye findings of premenopausal and postmenopausal women. Cureus. 2021;13(4):e14319.

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Published

2023-08-31

How to Cite

Verma, N., Gupta, P., & Sharma, A. (2023). Evaluation of difference in central corneal thickness between premenopausal and postmenopausal women. International Journal of Research in Medical Sciences, 11(9), 3256–3259. https://doi.org/10.18203/2320-6012.ijrms20232777

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Section

Original Research Articles