Histopathologic features of calcinosis cutis: a case series
DOI:
https://doi.org/10.18203/2320-6012.ijrms20233395Keywords:
Calcinosis cutis, Calcification, Basophilic acellular materialAbstract
Calcinosis cutis is a rare condition characterized by the abnormal deposition of calcium salts in the skin and subcutaneous tissues. It usually occurs as an isolated entity, but is also associated with various systemic disorders. We had reported 8 cases in our department in the past one year. A striking finding was that all of them had clinical symptoms of at least 6 months and had normal serum calcium levels. The gross evaluation of the specimen showed areas of calcification which pointed out towards the diagnosis to be consistent with calcinosis cutis. The various histologic findings were presence of basophilic acellular material corresponding to calcification, eosinophilic hyalinization, foreign body giant cell reaction and an Inflammatory infiltrate. All the biopsies had conclusive evidence of the first finding. It is evident that all the cases encompass a variety of morphological findings and aim to convey a clear histopathological understanding of the lesion for a prompt diagnosis.
References
Cuong L, Bedocs PM. Calcinosis cutis. Treasure Island (FL): StatPearls Publishing; 2023.
Jiménez-Gallo D, Ossorio-García L, Linares-Barrios M. Calcinosis cutis and calciphylaxis. Actas Dermo-Sifiliográficas (English Edition). 2015;106(10):785-94.
Bhat D, Parate S, Bobhate SK. Scrotal calcinosis presenting as nodular masses: A report of 4 cases. Indian J Dermatol. 2003;48(2):112.
Yadav P, Thind SS. Imaging features in calcinosis circumscripta, a rare type of subcutaneous calcification in localized scleroderma. Med J Dr. DY Patil University. 2013;6(4):444-6.
Reiter N, El-Shabrawi L, Leinweber B, Berghold A, Aberer E. Calcinosis cutis: part I. Diagnostic pathway. J Am Acad Dermatol. 2011;65(1):1-12.
Binayke R, Taksande RV. Cytodiagnosis of idiopathic calcinosis cutis-a rare diagnosis in three cases with review of literature. Int J Health Sci Res. 2017;7:1-6.
Reiter N, El-Shabrawi L, Leinweber B, Berghold A, Aberer E. Calcinosis cutis: part II. Treatment options. J Am Acad Dermatol. 2011;65(1):15-22.
Sahoo N, Sethy M, Mishra P, Patra S, Purkait S, Giri SK. Idiopathic scrotal calcinosis diagnosed by fine needle aspiration cytology-report of a rare case. Diagnostic Cytopathol. 2017;45(10):922-4.
Toprak T, Sekerci CA. Case reports of benign intrascrotal tumors: Two epidermoid cysts and one scrotal calcinosis. Archivio Italiano di Urologia e Andrologia. 2020;92(1):64-6.
Kankaya D, Şenel E, Dölek Y, Uslu A, Sertçelik A. Idiopathic scrotal calcinosis: the incorrect terminology of scrotal calcinosis. Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale. Societa Italiana di Dermatologia e Sifilografia. 2015;150(5):495-9.
