Relapse of Takayasu’s arteritis with tuberculosis relapse: a rare presentation

Sunil Chandrasen Chand, Aarti Ashok Gupta, Prasad Muley, Dulari Jitendra Gandhi

Abstract


Takayasu’s Arteritis (TA) is a disease of unknown etiology with incidence between 1.2 to 2.3 cases per million per year. It is a chronic granulomatous arteritis affecting large elastic arteries, predominantly the aorta, its main branches, pulmonary and coronary arteries characterized histologically by an inflammatory cell infiltrate that affects all the layers of the arterial wall. The etiology of TA is not clear but a causal relationship between TA and tuberculosis (TB) have been suggested. The first case of Takayasu’s arteritis was described in 1908 by Japanese ophthalmologist Mikito Takayasu. Despite the association with tuberculosis and the similarity between granulomatous lesions in both the diseases, the exact role of Mycobacterium tuberculosis in the pathogenesis of TA is still unknown.


Keywords


Takayasu’s arteritis, Tuberculosis, Relapse of Takayasu’s arteritis

Full Text:

PDF

References


Hall S, Buchbinder R. Takayasu’s arteritis. Rheum Dis Clin North Am. 1990;16:411.

Khaled Al-Aghbari, Ahmed Al-Motarreb, Faiza Askar. Takayasu’s arteritis associated with tuberculosis in a young Yemeni woman. Heart Views. 2010 Oct-Dec;11(3):117-20.

Seko Y, Takahashi N, Tada Y, Yagita H, Okumura K, Nagai R. Restricted usage of T-cell receptor Vgamma-Vdelta genes and expression of costimulatory molecules in Takayasu’s arteritis. Int J Cardiol. 2000;75(Suppl 1):S77-7.

Nityanand S, Mishra K, Shrivastava S, Holm G, Lefvert AK. Autoantibodies against cardiolipin and endothelial cells in Takayasu's arteritis. Prevalence and isotype distribution. Br J Rheumatol. 1997;36:923-4.

Seko Y, Minota S, Kawasaki A, Shinkai Y, Maeda K, Yagita H, et al. Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu’s arteritis. J Clin Invest. 1994;93:750-8.

Hernandez-Pando R, Reyes P, Espitia C, Wang Y, Rook G, Mancilla R. Raised agalactosyl IgG and antimycobacterial humoral immunity in Takayasu’s arteritis. J Rheumatol. 1994;21:1870-6.

Kumar Chauhan S, Kumar Tripathy N, Sinha N, Singh M, Nityanad S. Cellular and humoral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu’s Arteritis. Clin Exp Immunol. 2004;138(3):547-53.