Mirizzi syndrome-differential diagnosis with cholangiocarcinoma: case report
DOI:
https://doi.org/10.18203/2320-6012.ijrms20233399Keywords:
Jaundice syndrome, Mirizzi syndrome, Cholangiocarcinoma, Tumor markers, Differential diagnosisAbstract
Mirizzi syndrome is a rare complication of gallstone disease and poses a diagnostic challenge for general surgeons due to its clinical presentation, which resembles other pathological entities such as cholangiocarcinoma. We present a clinical case of a 68-year-old female patient with symptoms of jaundice and right upper quadrant pain. During the patient's diagnostic workup, altered liver function tests were documented, highlighting obstructive pattern hyperbilirubinemia, elevated tumor marker CA 19.9, and suspicion of biliary tract tumor based on imaging studies. However, surgical and pathological confirmation revealed Mirizzi syndrome. This case emphasizes the importance of considering differential diagnoses in patients presenting with obstructive jaundice to provide timely and appropriate treatment.
References
Mitsumoto GL, Monetta da Silva LA, Alves M, Martins M, Yvamoto NE, et al. Síndrome de Mirizzi que simula colangiocarcinoma. Reporte de caso. Acta Gastroenterológica Latinoamericana. 2020;50(2):197-208.
Hassan R, Solinas L, Notarangelo M, Sagnotta A, Giubilo C, Battaglia B, et al. Mirizzi syndrome: a challenging diagnosis. Case report. G Chir. 2019;40(3):193-8.
Clemente G, Tringali A, De Rose AM, Panettieri E, Murazio M, Nuzzo G, et al. Mirizzi Syndrome: Diagnosis and Management of a Challenging Biliary Disease. Canad J Gastroenterol Hepatol. 2018;1-6.
Rivera López FA, Guerrero Márquez GA, Miñana Echávarri F, Blancarte Linden AH. Colloduodenal Mirizzi syndrome, proposal to include variant Ia, Ib and its management in the new Beltrán classification. Cir gene. 2017;39(3):164-70.
Beltrán MA. Mirizzi syndrome: history, current knowledge and proposal of a simplified classification. World J Gastroenterol. 2012;18(34):4639-50.
Beltran MA, Csendes A, Cruces KS. The Relationship of Mirizzi Syndrome and Cholecystoenteric Fistula: Validation of a Modified Classification. World J Surg. 2008;32(10):2237-43.
Chon HK, Park C, Kim TH. Minimally Invasive Approach Using Digital Single-Operator Peroral Cholangioscopy-Guided Electrohydraulic Lithotripsy and Endoscopic Nasogallbladder Drainage for the Management of High-Grade Mirizzi Syndrome. Clin Endosc. 2021;54(6):930-4.
Moshref LH, Mandili RA, Almaghrabi M, Abdulwahab RA, Alosaimy RA, Miro J. Elevation of CA 19-9 in Mirizzi Syndrome in the Absence of Malignancy: A Case Report. Am J Case Rep. 2021;22:e931819-1.
Beltrán MA. Mirizzi syndrome: History, current knowledge and proposal of a simplified classification. World J Gastroenterol. 2012;18(34):4639.
Chen H, Siwo EA, Khu M, Tian Y. Current trends in the management of Mirizzi Syndrome. Medicine. 2018;97(4):e9691.
Cortés RM, Vázquez GA. Frecuencia del síndrome de Mirizzi en un hospital de enseñanza. Cir Gen. 2003;25(4):334-7.
