Medullary thyroid carcinoma spindle cell variant: a rare case report
DOI:
https://doi.org/10.18203/2320-6012.ijrms20233732Keywords:
MTC, RET proto-oncogene, MEN syndromeAbstract
Medullary thyroid carcinoma (MTC) accounts for only 4% of thyroid tumors and originates from parafollicular cells secreting calcitonin. However, it accounts for 13% of all thyroid cancer related death. We herein report a case of 50 years male who presented with a right neck swelling measuring 3×2×2 cm for 2 years, which was gradually increasing. Ultrasonography of the neck revealed a hypoechoic nodule in the right lobe of thyroid. There was no relevant family history. Patient was clinically euthyroid. Fine needle aspiration smears showed many dispersed spindle shaped cells and loosely cohesive clusters of cells. Nuclei of these cells are spindle shaped and showing moderate anisokaryosis. Clumps of hyaline material also seen. A provisional diagnosis of MTC spindle cell variant had been made, which was confirmed by histopathology. Early diagnosis of MTC is very important. Because if patient do not have metastatic disease usually cured by total thyroidectomy.
Metrics
References
Wells Jr SA, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma: the American Thyroid Association Guidelines Task Force on medullary thyroid carcinoma. Thyroid. 2015;25(6):567-610.
World Health Organization. Cancer Today-GLOBOCAN 2020. Available at: https://gco.iarc.fr/today/home. Accessed on 25 March 2023.
Jayarajah U, Fernando A, Prabashani S, Fernando EA, Seneviratne SA. Incidence and histological patterns of thyroid cancer in Sri Lanka 2001-2010: an analysis of national cancer registry data. BMC Cancer. 2018;18(1):1-7.
Lombardo F, Baudin E, Chiefari E, Arturi F, Bardet S. Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804. J Clin Endocrinol Metab. 2002;87(4):1674-80.
Giard RW, Hermans J. Use and accuracy of fine needle aspiration cytology in histologically 68 proven thyroid carcinoma: An audit using a national pathology database. Cancer. 2000;69;90(6):330-4.
Jayarajah U, Wijekoon M, Seneviratne SA. Prophylactic prednisolone for the prevention of early and intermediate adverse effects of radioactive iodine therapy in patients with thyroid cancer: study protocol for a single-centre, phase II/III, randomized, double-blinded, placebo-controlled clinical trial. Trials. 2020;21:812.
Horn RC. Carcinoma of the thyroid. Description of a distinctive morphological variant and report of 7 cases. Cancer. 1951;4:697-707.
Hazard JB, Hawk WA, Crile G Jr. Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab. 1959;19:152-61.
Orell SR, Sterrett GF, Whitaker D. Fine Needle Aspiration Cytology. 4th Edn. New Delhi: Elsevier. 2005;125-64.
Sangalli G, Serio G, Zampatti C, Bellotti M, Lomusio G. Fine needle aspiration cytology of 74 the thyroid: a comparison of 5469 cytological and final histological diagnoses. Cytopathology. 2006;75(17):245-50.
Kaushal S, Iyer VK, Mathur SR, Ray R. Fine needle aspiration cytology of medullary 81 carcinoma of thyroid with a focus on rare variants: A review of 78 cases. Cytopathology. 2011;82;22:95-105.
Mondal SK, Nag, Roy D, Bandyopadhyay, Ranjana. Spindle cell variant of medullary carcinoma of thyroid with nodal metastasis: Cytodiagnosis and diagnostic dilemma. Thyroid Res Pract. 2012;9(2):60-63.
Downloads
Published
How to Cite
Issue
Section
