Study of association between C-reactive protein and albuminuria in type 2 diabetes mellitus

Abhishek Rastogi; Ajay Kumar; Keerti Rastogi; Sangeeta Kapoor; Tariq Mahmood

doi:10.18203/2320-6012.ijrms20233388

Authors

Abhishek Rastogi Department of Medical Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India
Ajay Kumar Department of Medicine, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India
Keerti Rastogi Department of Medical Biochemistry, Government Medical College, Kannauj, Uttar Pradesh, India
Sangeeta Kapoor Department of Medical Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India
Tariq Mahmood Department of Medical Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20233388

Keywords:

Type 2 diabetes mellitus, Diabetic nephropathy, C-reactive protein, Albuminuria, Microvascular complication

Abstract

Background: Inflammatory markers are excessively produced by adipocytes in T2DM due to obesity-induced dysregulation of adipocytes. Inflammation is recognised by elevated level of inflammatory markers like C-reactive protein. It has been reported that patients with nephropathy and those with albuminuria have higher levels of inflammatory markers.

Methods: Study design observational descriptive cross-sectional study. 150 subjects having age more than 30 years and less than 55 years diagnosed with type 2 diabetes mellitus were included. HbA1c, FPG, creatinine, urea, CRP, and albuminuria were analysed.

Results: A strong and statistically significant correlation was seen between serum CRP levels and albuminuria levels with a p value of 0.831 and a p value of 0.00. The study group was divided into two groups with normal CRP (n=40) and elevated CRP (n=110). Average values of all parameters showed a statistically significant increase in the group with abnormal CRP levels. In the ROC analysis, an area of .957 under the curve shows a very high predictive value of 15.5 mg/l of CRP for predicting albuminuria in patients of T2DM.

Conclusions: From our results, we have been able to establish a strong association as well as a predictive relationship between the level of CRP and albuminuria in T2DM. We have shown that serum CRP levels at a cut-off of 15.5 mg/l are a predictor of clinically significant albuminuria. This makes serum CRP level an effective screening tool for albuminuria.

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