Pervasiveness of metabolic syndrome and cardiovascular disease in tribal/rural population of India: a review

Aayushi Nagwanshi; Tapas Chakma; Shikha Nag; Kritika Singh; Arvind Kavishwar; Pranshi Verma; Suyesh Shrivastava

doi:10.18203/2320-6012.ijrms20233743

Authors

Aayushi Nagwanshi ICMR-NIRTH Jabalpur, Madhya Pradesh, India
Tapas Chakma ICMR-NIRTH Jabalpur, Madhya Pradesh, India
Shikha Nag ICMR-NIRTH Jabalpur, Madhya Pradesh, India
Kritika Singh ICMR-NIRTH Jabalpur, Madhya Pradesh, India
Arvind Kavishwar ICMR-NIRTH Jabalpur, Madhya Pradesh, India
Pranshi Verma ICMR-NIRTH Jabalpur, Madhya Pradesh, India
Suyesh Shrivastava ICMR-NIRTH Jabalpur, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20233743

Keywords:

CVDs, Mets, Tribal

Abstract

Diseases classified as non-communicable diseases (NCDs) are those that are often caused by unhealthy behaviors rather than by infection or by contact with others. One of the main NCDs causing many fatalities is cardiovascular disease (CVD). Recent research has shown that the prevalence of metabolic syndrome (Mets) associated CVDs among tribal populations is increasing in rapid pace. In this review, we have included studies investigating the components of Mets and the relationships between Mets and CVDs. From the assessment of studies, we may predict a significant association between Mets and CVDs as a whole. Our evaluation of these studies revealed that carrying at least three Mets risk components, like hyperglycemia, obesity, dyslipidemia, and high blood pressure, significantly enhances the risk of CVDs. Undernutrition, smoking, and a low intake of fruits and vegetables in the Indian tribal population are the main risk factors for managing Mets associated CVDs. Furthermore, various studies have also shown that Mets may be influenced by genetic and environmental factors. Finally, healthy habits such as a balanced diet and frequent exercise should be introduced from a young age in individuals, to prevent Mets progression. In order to combat the Mets associated CVDs, functionally upgraded primary health centers and special IECs (Information, education and communication) programs may play a beneficial role. Furthermore, strengthening public healthcare systems and focusing on prevention, early identification, and treatment using medical and social interventions can be of immense help in managing the metabolic risk factors that can lead to CVDs.

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References

Kassi E, Pervanidou P, Kaltsas G, Chrousos G. Metabolic syndrome: definitions and controversies. BMC Med. 2011;9:48.

Huang PL. A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009;2(5-6):231-7.

Krishnamoorthy Y, Rajaa S, Murali S, Rehman T, Sahoo J, Kar SS. Prevalence of metabolic syndrome among adult population in India: A systematic review and meta-analysis. PLoS One. 2020;15(10):e0240971.

Prasad DS, Kabir Z, Dash AK, Das BC. Prevalence and risk factors for metabolic syndrome in Asian Indians: A community study from urban Eastern India. J Cardiovasc Dis Res. 2012;3(3):204-11.

Tune JD, Goodwill AG, Sassoon DJ, Mather KJ. Cardiovascular consequences of metabolic syndrome. Transl Res. 2017;183:57-70.

Sharma SK, Ghimire A, Radhakrishnan J, Thapa L, Shrestha NR, Paudel N et al. Prevalence of hypertension, obesity, diabetes, and metabolic syndrome in Nepal. Int J Hypertens. 2011;2011:821971

GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1736-88.

World health organization. Available at: file:///C:/Users/Admin/Downloads/WHF-Cardiovascular-diseases-in-India.pdf. Accessed on 23 June, 2023.

Kandpal V, Sachdeva MP, Saraswathy KN. An assessment study of CVD related risk factors in a tribal population of India. BMC Public Health. 2016;16:434.

Angell SY, McConnell MV, Anderson CAM, Bibbins-Domingo K, Boyle DS, Cape well S et al. The American Heart Association 2030 Impact Goal: a presidential advisory from the American Heart Association. Circulation. 2020;141:e000.

Gupta R, Joshi P, Mohan V, Reddy KS, Yusuf S. Epidemiology and causation of coronary heart disease and stroke in India. Heart. 2008;94(1):16-26.

Mensah GA, Roth GA, Fuster V. The Global Burden of Cardiovascular Diseases and Risk Factors: 2020 and beyond. J Am Coll Cardiol. 2019;74(20):2529-32.

Noale M, Limongi F, Maggi S. Epidemiology of Cardiovascular Diseases in the Elderly. Adv Exp Med Biol. 2020;1216:29-38.

Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812-23.

Lu L, Liu M, Sun R, Zheng Y, Zhang P. Myocardial Infarction: Symptoms and Treatments. Cell Biochem Biophys. 2015;72(3):865-7.

Mosterd A, Hoes AW. Clinical epidemiology of heart failure. Heart. 2007;93(9):1137-46.

Vamadevan AS, Shah BR, Califf RM, Prabhakaran D. Cardiovascular research in India: a perspective. Am Heart J. 2011;161(3):431-8.

Deshmukh PR, Kamble P, Goswami K, Garg N. Metabolic syndrome in the rural population of Wardha, central India: an exploratory factor analysis. Indian J Community Med. 2013;38(1):33-8.

Gautam Kumar K. Changing Perspectives of Tribal Health in the Context of Increasing Lifestyle Diseases in India. J Environ Soc Sci. 2014;1(1):101.

Census of India 2011. Office of the Registrar General abd Census Commissioner, India. India. Available at: https://censusindia.gov.in/nada/index.php/catalog/42619. Accessed on 25 June, 2023.

Akil L, Ahmad HA. Relationships between obesity and cardiovascular diseases in four southern states and Colorado. J Health Care Poor Underserved. 2011;22(4):61-72.

Kshatriya GK, Acharya SK. Triple Burden of Obesity, Undernutrition, and Cardiovascular Disease Risk among Indian Tribes. PLoS One. 2016;11(1):e0147934.

Hedayatnia M, Asadi Z, Zare-Feyzabadi R, Yaghooti-Khorasani M, Ghazizadeh H, Ghaffarian-Zirak R et al Dyslipidemia and cardiovascular disease risk among the MASHAD study population. Lipids Health Dis. 2020;19(1):42.

MSD Manual consumer version. Available at: https://www.msdmanuals.com/en-in/home/hormonal-and-metabolic-disorders/diabetes-mellitus-dm-and-disorders-of-blood-sugar-metabolism/diabetes-mellitus-dm. Accessed on 15 July, 2023.

Münzel T, Hahad O, Kuntic M, Keaney JF, Deanfield JE, Daiber A. Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes. Eur Heart J. 2020;41(41):4057-70.

Chaudhari HE, Patil SD. Assessment of hazardous elements of metabolic syndrome in hypertensive patients to defend them from cardiovascular risk in tribal region. Diabetes Metab Syndr. 2019;13(2):925-931.

Krupp K, Adsul P, Wilcox ML, Srinivas V, Frank E, Srinivas A et al. Prevalence and correlates of metabolic syndrome among rural women in Mysore, India. Indian Heart J. 2020;72(6):582-8.

Kalkonde YV, Deshmukh MD, Sahane V, Puthran J, Kakarmath S, Agavane V et al. Stroke Is the Leading Cause of Death in Rural Gadchiroli, India: A Prospective Community-Based Study. Stroke. 2015;46(7):1764-8.

Hathur B, Basavegowda M, Kulkarni P, Ashok NC. Metabolic syndrome among diabetics and pre-diabetics of JenuKuruba tribe in Mysore district (JKDHS-2)-An evidence of metabolic abnormalities leading to increase in CVD's among Jenu Kuruba tribal population. Diabetes Metab ndr. 2015;9(4):205-9.

Bhatti GK, Bhadada SK, Vijayvergiya R, Mastana SS, Bhatti JS. Metabolic syndrome and risk of major coronary events among the urban diabetic patients: North Indian Diabetes and Cardiovascular Disease Study-NIDCVD-2. J Diabetes Complications. 2016 ;30(1):72-8.

Iyengar SS, Gupta R, Ravi S, Thangam S, Alexander T, Manjunath CN et al. Premature coronary artery disease in India: coronary artery disease in the young (CADY) registry. Indian Heart J. 2017;69(2):211-216.

Harikrishnan S, Sarma S, Sanjay G, Jeemon P, Krishnan MN, Venugopal K et al. Prevalence of metabolic syndrome and its risk factors in Kerala, South India: Analysis of a community based cross-sectional study. PLoS One. 2018;13(3):e0192372.

Sen P, Das S, Choudhuri D. Correlates of cardiometabolic risk factors among women of an ethnic tribal community of Tripura. Indian J Public Health. 2017;61(3):208-210.

Swarn S, Prasad I, Kumar S, Singh BS, Singh GP Prevalence of Metabolic Syndrome and Identification of Cardiovascular Disease Risk Factors Among Medical Students. Int J Pharmaceutical Clin Res. 2022;14(1);602-8.

Elder SJ, Lichtenstein AH, Pittas AG, Roberts SB, Fuss PJ, Greenberg AS et al. Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome. J Lipid Res. 2009;50(9):1917-26.

Rochlani Y, Pothineni NV, Kovelamudi S, Mehta JL. Metabolic syndrome: pathophysiology, management, and modulation by natural compounds. Ther Adv Cardiovasc Dis. 2017;11(8):215-25.

Statello L, Guo CJ, Chen LL, Huarte M. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 2021;22(2):96-118.

Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A et al. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ Res. 2014;114(10):1569-75.

Kong Y, Hsieh CH, Alonso LC. ANRIL: A lncRNA at the CDKN2A/B Locus with Roles in Cancer and Metabolic Disease. Front Endocrinol (Lausanne). 2018;9:405.

Zhou S, Jin JP, Wang JQ. miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacol Sin. 2018;39:1073-84.

Abdul-Aziz AA, Desikan P, Prabhakaran D, Schroeder LF. Tackling the Burden of Cardiovascular Diseases in India. Circ Cardiovasc Qual Outcomes. 2019;12(4):e005195.

Goradel NH, Hour FG, Negahdari B, Malekshahi ZV, Hashemzehi M, Masoudifar A et al. Stem Cell Therapy: A New Therapeutic Option for Cardiovascular Diseases. J Cell Biochem. 2018;119(1):95-104.

Prabhakaran D, Jeemon P, Roy A. Cardiovascular Diseases in India: Current Epidemiology and Future Directions. Circulation. 2016;133(16):1605-20.

Shrivastava S, Singh K, Chakma T and Kavishwar A (2023) Metabolic syndrome in Indian tribes: challenges to reveal its true status. Front. Clin. Diabetes Healthc. 2023;4:1194471.

Tapas C, Arvind K, Ravendra KS, Vinay R. High prevalence of hypertension and its selected risk factors among adulttribal population in Central India. Pathogens Glob Heal. 2017;111(7):343-50.

Kaur P, Borah PK, Gaigaware P, Mohapatra PK, R Das NK et al. Preparedness of primary and secondary care health facilities for the management of non-communicable diseases in tribal population across 12 districts in India. Indian J Med Res. 2022;156(2):260-8.

Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, Zugaza JL et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018;15(12):731-43.

Tang GY, Meng X, Li Y, Zhao CN, Liu Q, Li HB. Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms. Nutrients. 2017;9(8):857.