Study of breast lesions in cytology and its histopathological correlation
DOI:
https://doi.org/10.18203/2320-6012.ijrms20233709Keywords:
Fibroadenoma, FNAC, Invasive ductal carcinoma, Triple test, Yokohama reporting systemAbstract
Background: Breast cancer is commonly diagnosed malignancy in females and is leading cause of death. Malignant lesions mostly occur after menopause. Fine needle aspiration cytology is minimally invasive technique, used in triple test and produces speedy results. It can able to differentiate between benign and malignant lesions of breast lump. Our study aims to categorize the breast lesion and to correlate FNAC with histopathological studies.
Methods: This retrospective study was done in department of pathology from July 2021 to May 2023.107 cases were undergone FNAC and slides were examined and lesions were categorized. Tissue biopsies were obtained, processed and histological sections were made and examined. The FNAC findings were correlated and analyzed with histological findings.
Results: Right breast lesions (55%) were more in our study than left breast lesions (42%). Totally 77 cases were diagnosed as benign lesions by FNAC of which 37 cases were biopsied and histological diagnosis of all cases shown as benign category. 6 cases were diagnosed as proliferative breast disease with atypia of which only one case was received for biopsy and diagnosed as atypical ductal hyperplasia. 12 cases were diagnosed as malignancy and 6 biopsies were received with 5 cases were diagnosed as malignant lesions. Sensitivity and Specificity of FNAC in breast lesions were 100% and 97.43% respectively.
Conclusions: FNAC is rapid and valuable tool with high sensitivity, specificity and low false positivity. It is useful in preoperative evaluation and avoids unnecessary surgical intervention.
References
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
Work ME, Andrulis IL, John EM, Hopper JL, Liao Y, Zhang FF, et al. Risk factors for uncommon histologic subtypes of breast cancer using centralized pathology review in the Breast Cancer Family Registry. Breast Cancer Res Treat. 2012;134(3):1209-20.
Roussel F, Dalion J, Benozio M. The risk of tumoral seeding in needle biopsies. Acta Cytol. 1989;33:936-9.
Kocjan G, Bourgain C, Fassina A, Hagmar B, Herbert A, Kapila K, Kardum‐Skelin I, Kloboves‐Prevodnik V, Krishnamurthy S, Koutselini H, Majak B. The role of breast FNAC in diagnosis and clinical management: a survey of current practice. Cytopathol. 2008;19(5):271-8.
Basnet S, Talwar OP. Role of cell block preparation in neoplastic lesions. J Pathol Nepal. 2012;2(4):272-6.
Siddegowda MS, Ara T. Correlation of fine needle aspiration cytology with histopathology of malignant breast lesions in a tertiary care hospital- Mandya. J Evid Based Med Healthc. 2019;6(41):2697-701.
Balasundaram, Nilavazhagan A. Comparative study with clinico-pathological correlation between ultrasonography, mammography and fine needle aspiration cytology in evaluation of breast lumps in coastal population of Karaikal. IAIM. 2019;6(9):21–7.
Begum F, Kumar PR. Diagnostic correlation of palpable breast masses by cytology and histopathology: A prospective study. IAIM. 2018;5(11):44-9.
Domínguez F, Riera JR, Tojo S, Junco P. Fine needle aspiration of breast masses. An analysis of 1,398 patients in a community hospital. Acta Cytol. 1997;41(2):341-7.
Tiwari M. Role of fine needle aspiration cytology in diagnosis of breast lumps. Kathmandu Univ Med J (KUMJ). 2007;5(2):215-7.
Qasim M, Ali J, Akbar SA, Mustafa S. Lump breast: Role of FNAC in diagnosis. Prof Med J. 2009;16:235-8.
Srikanth S. Cytological and histopathological correlation of breast lesions –a study of one hundred cases. Indian J Pathol Oncol. 2017;4(2):273-7.
Yalavarthi S, Tanikella R, Prabhala S, Tallam US. Histopathological and cytological correlation of tumors of breast. Med J Dr DY Patil Univ. 2014;7(3):326-31.
Rocha PD, Nadkarni NS, Menezes S. Fine needle aspiration biopsy of breast lesions and histopathologic correlation. Acta Cytologica. 1997;41(3):705-12.
Khemka A, Chakrabarti N, Shah S, Patel V. Palpable breast lumps: Fine-needle aspiration cytology versus histopathology: A correlation of diagnostic accuracy. Internet J Surg. 2009;18:1.
MacIntosh RF, Merrimen JL, Barnes PJ. Application of the Probabilistic Approach to Reporting Breast Fine Needle Aspiration in Males. Acta Cytologica. 2008;52(5):530-4.
Risaldar AA, Begum Z, Alvi U. Correlation of FNAC with Histopathology of breast lesions. IP J Diagn Pathol Oncol. 2020;5(4):375-380.
Rupom TU, Choudhury T, Banu SG. Study of fine needle aspiration cytology of breast lump: correlation of cytologically malignant cases with their histological findings. Bangabandhu Sheikh Mujib Med Univ J. 2011;4(2):60-4.
Meena SP, Hemrajani DK, Joshi N. A comparative and evaluative study of cytological and histological grading system profile in malignant neoplasm of breast - An important prognostic factor. Indian J Pathol Microbiol. 2006;49:199.
Reddy DG, Reddy CRR. Carcinoma of the breast, its incidence and histological variants among South Indians. Indian J Med Sci. 1958;12(4):228–34.
Clegg-Lamptey J, Hodasi W. A study of breast cancer in korle bu teaching hospital: Assessing the impact of health education. Ghana Med J. 2007;41(2):72-7.
Chiemchanya S, Mostafa MG. Fine needle aspiration cytology in the diagnosis of breast lump. J Bangladesh Coll Physicians Surg. 2000;18:61-5.
Ibikunle DE, Omotayo JA, Ariyibi OO. Fine needle aspiration cytology of breast lumps with histopathologic correlation in Owo, Ondo State, Nigeria: a five-year review. Ghana Med J. 2017;51(1):1-5.
Ariga RI, Bloom K, Reddy VB, Kluskens L, Francescatti D, Dowlat K, et al. Fine needle aspiration of clinically suspicious palpable breast masses with histopathological correlation. Am J Surg. 2002;184 (5):410-3.
Sankaye SB, Dongre SD. Cytological study of palpable breast lumps presenting in an Indian rural setup. Indian J Med Paediatric Oncol. 2014;35(2):159-64.
Shrilakshmi HP, Chavda JA. Study of cytohistologic correlation of breast lesions. Nat J Integra Res Medi. 2013;4(2):54-6.
Agarwal R, Mohan N, Sharan J, Gupta G, Kumar P. Spectrum of breast diseases with cyto–histopathological correlation in a tertiary care hospital of Western Uttar Pradesh. Indian J Pathol Oncol. 2017;4(1):1-7.
Mahajan N A, Bhale CP, Mulay SS. Fine needle aspiration cytology of breast lesions and correlation with histopathology- A 2 year study. Int J Health Sci Res. 2013;3(2):55-65.
