When you least expect it: nephrotic syndrome following dengue fever
DOI:
https://doi.org/10.18203/2320-6012.ijrms20233739Keywords:
Dengue, Nephrotic, FSGSAbstract
This case report highlights a rare occurrence of nephrotic syndrome in a previously healthy 20-year-old gentleman. The patient exhibited bilateral lower limb swelling, facial puffiness, and abdominal distension. Notably, he had been hospitalized two weeks prior with dengue fever, characterized by a transient reduction in platelet counts. Routine examinations revealed proteinuria, with creatinine at 0.97 and albumin at 2.2. A renal biopsy confirmed focal segmental glomerulosclerosis (FSGS)- NOS type. This case underscores the significance of considering renal complications in individuals with recent dengue fever, especially when presented with atypical symptoms. The scarcity of reported cases depicting nephrotic syndrome as a sequelae to dengue fever further emphasizes the uniqueness of this scenario.
References
Gubler DJ. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002;10(2):100-3.
Jessie K, Fong MY, Devi S, Lam SK, Wong KT. Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization. J Infect Dis. 2004 Apr 15;189(8):1411-8.
Lima Mda R, Nogueira RM, Schatzmayr HG, Filippis AM, Limonta D, Santos FB. A new approach to dengue fatal cases diagnosis: NS1 antigen capture in tissues. PLoS Negl Trop Dis. 2011;5(5):e1147.
Balsitis SJ, Coloma J, Castro G, Alava A, Flores D, McKerrow JH, et al. Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg. 2009;80(3):416-24.
Nunes PCG, Rioja LDS, Coelho JMCO, Salomão NG, Rabelo K, José CC, et al. Renal Injury in DENV-4 Fatal Cases: Viremia, Immune Response and Cytokine Profile. Pathogens. 2019;8(4):223.
Boonpucknavig V, Bhamarapravati N, Boonpucknavig S, Futrakul P, Tanpaichitr P. Glomerular changes in dengue hemorrhagic fever. Arch Pathol Lab Med. 1976;100(4):206-12.
Lizarraga KJ, Nayer A. Dengue-associated kidney disease. J Nephropathol. 2014;3(2):57-62.
Eswarappa M, Reddy SB, John MM, Suryadevara S, Madhyashatha RP. Renal manifestations of dengue viral infection. Saudi J Kidney Dis Transpl. 2019;30(2):394-400.
Prasad N, Novak JE, Patel MR. Kidney Diseases Associated With Parvovirus B19, Hanta, Ebola, and Dengue Virus Infection: A Brief Review. Adv Chronic Kidney Dis. 2019;26(3):207-19.
Araújo SA, Cordeiro TME, Belisário AR, Araújo RFA, Marinho PES, Kroon EG, et al. First report of collapsing variant of focal segmental glomerulosclerosis triggered by arbovirus: dengue and Zika virus infection. Clin Kidney J. 2018;12(3):355-61.