Histopathological spectrum in cases of abnormal uterine bleeding: a cross sectional study in tertiary care hospital in Tripura
DOI:
https://doi.org/10.18203/2320-6012.ijrms20233983Keywords:
Abnormal uterine bleeding, Histopathology, Endometrium, LeiomyomaAbstract
Background: Majority women encounter abnormal uterine bleeding in their life where the causes are not limited to cancer even unknown. The actual cause has not been studied in north-east part of India. This data is scarce in State of Tripura. The present study aims to find out histomorphological patterns of AUB reported in AGMC & GBP Hospital in a calendar year.
Methods: A cross sectional study was conducted over 2 calendar year from 2021 to 2022 where the cases of AUB irrespective of age, who had undergone endometrial biopsy, endometrial curettage and hysterectomy in Obstetrics and Gynaecology department, AGMC were examined histomorphologically in the dept of Pathology, AGMC. Data were collected in predesigned proforma and analysed using SPSS 21.0 and expressed in both descriptive and inferential statistics. Ethical approval was taken.
Results: Total 220 cases of AUB specimens were examined. Among the reported AUB cases, the mean age is 42.5±7.42 year. Overall, 16.81% of the cases of AUB shows normal tissue pattern and 83.19% with abnormal endometrial tissue. Out of 220 sample of AUB, the commonest cause was leiomyoma (20.45%) followed by endometrial hyperplasia (17.27%), adenomyosis (14.54%), mixed tumour lesion (9.09%), endometrial carcinoma (4.54%) and 1.35% shows cervical cancer.
Conclusions: Study concluded that In Tripura, majority AUB cases are due to leiomyoma, endometrial hyperplasia, adenomyosis and mixed inflammation indicating proper screening during reproductive stage of the women.
References
Dadpay M. Management of acute abnormal uterine bleeding in nonpregnant reproductive-age women. Obster Gynecol. 2013;121:891-6.
Cheong Y, Cameron IT, Critchley OD. Abnormal uterine bleeding. Br Med Bull. 2017;123(1):103-14.
Bindroo S, Garg M, Kaur T. Histopathological spectrum of endometrium in abnormal uterine bleeding. Int J Reprod Contracept Obstet Gynecol. 2018;7(9):3633-37.
Juan R. Surgical Pathology. 10th ed. India: Elsevier; 2011:1636-45.
Keith ED. Dewhurst’s Textbook of Obstetrics & Gynaecology. Abnormal uterine bleeding. 8th ed. USA: John Wiley and Sons Ltd.; 2012:421-34.
Berek JS, Hacker NF. Gynecologic Oncology. 6th ed. USA: Wolters Kluwer; 2015:944.
Kurman RJ, TeLinde RW. Blaustein’s Pathology of the Female Genital Tract. 6th ed. USA: Springer-Verlag; 2011:1075-135.
Padubidri VG, Daftary SN. Textbook of Gynaecology. 16th ed. India: Elsevier; 2015:342-59.
Robboy SJ, Anderson MC. Robboy’s Pathology of the Female Reproductive Tract. 2nd ed. UK: Churchill Livingstone; 2010:117-33.
Kumar V, Abbas AK, Aster JC. Pathologic Basis of Disease. 9th ed. India: Elsevier; 2015:985-1036.
Dutta D. Textbook of gynaecology. 6th ed. India: Jaypee Brothers Medical Publishers Ltd.; 2013:185-97.
Hyanki G, Pant P, Rizvi G. Endometrial biopsy in abnormal uterine bleeding: An effective tool in minimizing unnecessary hysterectomies. Saudi J Pathol Microbiol. 2019;4(1):21-5.
Saraswathi D, Thanka J, Rao S, Rajkumar A, Vijayaraghavan J, Kumar PV. Study of Endometrial Pathology in Abnormal Uterine Bleedi. J Obstet Gynecol India. 2011;61(4):426-30.
Soleymani E, Ziari K, Rahmani O, Dadpay M, Taheri Dolatabadi M, Alizadeh K, et al. Histopathological findings of endometrial specimens in abnormal uterine bleeding. Arch Gynecol Obstet. 2014; 289(4):84-92.
Naeem N, Samad A, Sartaj S, Farooq M, Fayyaz N. Histopathological spectrum of endometrial lesions in cases of abnormal uterine bleeding at a tertiary care hospital. Professional Med J. 2020;27(8):1692-6.
Patel AS, Shah KJ. Histopathological analysis of hysterectomy specimens in tertiary care centre: two years study. Trop J Pathol Microbiol. 2018;4(1):34-9.
Iqbal MB, Kambale T, Khandelwal A, Koshy A, Banerjee B. Spectrum of Endometrial lesions in patients presenting with abnormal uterine bleeding: Indian J Patho Oncol. 2018;5(4):587-91.
Sujatha R, Jaishree T, Manjunatha YA. Histomorphological analysis of uterine and cervical lesions in hysterectomy specimens at a tertiary care hospital. J Diagnostic Pathol Oncol. 2019;4(1):72-7.
Gayathri BN, Pattanashetti MA, Priyadarshini MM. Histopathological study of myometrial lesions of uterus in a tertiary care hospital of South India. J Evid Based Med Health. 2021;8(6):2349-70.
Snehal C, Rahul P, Shital D, Nitin T. Histopathological spectrum of uterine and cervical lesions in hysterectomy specimens. J Med Sci Clin Res. 2018;6(1):32699-701.
Praseeda CM, Sreedevi P K. Study of endometrial histopathology in abnormal uterine bleeding. Int J Pathol. 2019;10(2):108-11.
Sapna C, Krishnapriya R. Clinical profile of endometrial histopathological patterns in abnormal uterine bleeding. Nep J Obstet Gynecol. 2020;15(30): 50-4.
Suwarna BP, Bhupendra VP, Swarada VK, Snehal RP, Pradeep SU, et al. Importance of histopathological study of endometrial biopsy in management of abnormal uterine bleeding. Global J Res Anal. 2020;9(6):97-100.
Megha SK, Shweta W, Shubha D. Clinicopathological study of abnormal uterine bleeding- A two years study at tertiary care center. Int J Med Res Health Sci. 2021;10(6):1-8.
