The clinical features and prognosis of COVID-19 in diabetic patients

Authors

  • Ashok Kumar Behera Department of General Medicine, Bhima Bhoi Medical College and Hospital, Balangir, Odisha, India
  • Saubhagya Chhotaray Department of Emergency Medicine, Bhima Bhoi Medical College and Hospital, Balangir, Odisha, India
  • Sabitri Beshra Department of Pharmacology, Bhima Bhoi Medical College and Hospital, Balangir, Odisha, India
  • Chhatray Marndi Department of General Medicine, Bhima Bhoi Medical College and Hospital, Balangir, Odisha, India
  • Gopabandhu Patra Department of Orthopaedics, Bhima Bhoi Medical College and Hospital, Balangir, Odisha, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20233979

Keywords:

Hyperglycemia, COVID-19, RT-PCR, Diabetes

Abstract

Background: It is well-recognized that uncontrolled glycemia reflects the severity and mortality rates of respiratory virus epidemics. The aim of the study was to report the features and course of therapy of diabetic individuals admitted to a tertiary care facility with COVID-19 infection. Additionally, we tried to assess how hyperglycemia affected the clinical results.

Methods: This study used observational methods to conduct a retrospective chart review of 125 cases from October 2021 to March 2022 at a single center.

Results: Males made up 94.6% of the 125 examined cases. Within the age range of 21 to 78 years, the study group's average age was 49.6±10.4 years. Of the patients, 66.4% had prior knowledge of diabetes. When compared to pre-existing diabetes individuals with the newly diagnosed diabetes individuals, the latter had a higher death rate (p=0.03) and needed mechanical breathing (p=0.02).

Conclusions: Hyperglycemia that is uncontrolled harms COVID-19-infected patients. There is an increased risk of hyperglycemia problems that have been discovered or unknown.to screen for cases of undiscovered diabetes in hospital patients, which may be especially relevant during the COVID-19 pandemic, optimal glycemia optimization is essential.

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References

Zhang Y, Cui Y, Shen M, Zhang J, Liu B, Dai M, et al. Association of diabetes mellitus with disease severity and prognosis in COVID-19: A retrospective cohort study. Diabetes Res Clin Pract. 2020;165:108227.

Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C, et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev. 2020;36(7):e3319.

Mantovani A, Byrne CD, Zheng MH, Targher G. Diabetes as a risk factor for greater COVID-19 severity and in-hospital death: A meta-analysis of observational studies. Nutr Metab Cardiovasc Dis. 2020;30(8):1236-48.

Schoen K, Horvat N, Guerreiro NFC, de Castro I, de Giassi KS. Spectrum of clinical and radiographic findings in patients with diagnosis of H1N1 and correlation with clinical severity. BMC Infect Dis. 2019;19(1):964.

Yang JK, Feng Y, Yuan MY, Yuan SY, Fu HJ, Wu BY, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet Med. 2006;23(6):623-8.

Yang JK, Feng Y, Yuan MY, Yuan SY, Fu HJ, Wu BY, et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabet Med. 2006;23(6):623-8.

Moutschen MP, Scheen AJ, Lefebvre PJ. Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections. Diabete Metab. 1992;18(3):187-201.

Schuetz P, Castro P, Shapiro NI. Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care. 2011;34(3):771-8.

Yang JK, Lin SS, Ji XJ, Guo LM. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2010;47(3):193-9.

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843.

Wong HYF, Lam HYS, Fong AH, Leung ST, Chin TW, Lo CSY, et al. Frequency and Distribution of Chest Radiographic Findings in Patients Positive for COVID-19. Radiology. 2020;296(2):72-8.

Sattar N, McInnes IB, McMurray JJV. Obesity Is a Risk Factor for Severe COVID-19 Infection: Multiple Potential Mechanisms. Circulation. 2020;142(1):4-6.

Cariou B, Hadjadj S, Wargny M, Pichelin M, Al-Salameh A, Allix I, et al. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 2020;63(8):1500-15.

Zhu L, She ZG, Cheng X, Qin JJ, Zhang XJ, Cai J, et al. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020 Jun 2;31(6):1068-77.

Hamoudi R, Saheb Sharif-Askari N, Saheb Sharif-Askari F, Abusnana S, Aljaibeji H, Taneera J, et al. Prediabetes and diabetes prevalence and risk factors comparison between ethnic groups in the United Arab Emirates. Sci Rep. 2019;9(1):17437.

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Published

2023-12-28

How to Cite

Behera, A. K., Chhotaray, S., Beshra, S., Marndi, C., & Patra, G. (2023). The clinical features and prognosis of COVID-19 in diabetic patients. International Journal of Research in Medical Sciences, 12(1), 87–90. https://doi.org/10.18203/2320-6012.ijrms20233979

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Original Research Articles