Serum urea: an independent risk factor for cataract
DOI:
https://doi.org/10.18203/2320-6012.ijrms20241235Keywords:
Urea, Blood urea nitrogen, Cataract, HyperuricemiaAbstract
Background: Elevated levels of blood urea/blood urea nitrogen in serum is considered an independent risk factor for the occurrence of cataract. Estimation of these levels can be used as a predictor for the occurrence of cataract.
Methods: This was a hospital-based prospective case control study conducted in the department of ophthalmology at SKIMS MCH, Srinagar from January 2023 to June 2023. We evaluated 25 patients admitted for cataract surgery in our department for serum urea and BUN levels and compared their results with 25 age and sex-matched controls admitted for causes other than cataract. The cases with significantly elevated levels of urea were further screened for possible renal impairment using Glomerular filtration rates and urine albumin.
Results: 7 out of 25 cases had elevated levels of serum urea with a mean of 44.2±16.19 mg/dl whereas all 25 patients of the control group had normal serum urea levels with a mean of 28.84±4.3 mg/dl. The mean levels of urea were significantly higher in the cases than controls with p<0.0001. 4 out of the 7 patients in the case group with elevated serum urea levels showed impaired glomerular filtration rates and clinically significant levels of urine albumin.
Conclusions: The study suggested a statistically significant correlation (p<0.0001) between serum levels of urea and BUN with cataract.
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References
GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):e144-60.
GBD 2019 Blindness and Vision Impairment Collaborators; Vision Loss Expert Group of the Global Burden of Disease Study. Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):e130-43.
Liu YC, Wilkins M, Kim T, Malyugin B, Mehta JS. Cataracts. Lancet. 2017;390:600-12.
Ang MJ, Afshari NA. Cataract and systemic disease: a review. Clin Exp Ophthalmol. 2021;49: 118-27.
Modenese A, Gobba F. Cataract frequency and subtypes involved in workers assessed for their solar radiation exposure: a systematic review. Acta Ophthalmol. 2018;96:779-88.
Taylor HR, West SK, Rosenthal FS, Munoz B, Newland HS, Abbey H, et al. Effect of ultraviolet radiation on cataract formation. N Engl J Med. 1988;319:1429-33.
Wu H, Zhang H, Li P, Gao T, Lin J, Yang J, et al. Association between dietary carbohydrate intake and dietary glycemic index and risk of age-related cataract: a meta-analysis. Invest Ophthalmol Vis Sci. 2014;55:3660-8.
Kiziltoprak H, Tekin K, Inanc M, Goker YS. Cataract in diabetes mellitus. World J Diab. 2019; 10:140-53.
Poh S, Mohamed ARB, Lamoureux EL, Wong TY, Sabanayagam C. Metabolic syndrome and eye diseases. Diab Res Clin Pr. 2016;113:86-100.
Rim TH, Yoon CY, Park HW, Chung EJ. Association between starting hemodialysis for end-stage renal disease and incident cataract surgery: a 12-year nationwide cohort study. Invest Ophthalmol Vis Sci. 2016;57:1112-9.
Qin YJ, Chan SO, Lin HL, Zhang YQ, Chen YL, Niu YY, et al. Elevated level of uric acid in aqueous humour is associated with posterior subcapsular cataract in human lens. Clin Exp Ophthalmol. 2020; 48:1183-91.
Yeum KJ, Russell RM, Krinsky NI, Aldini G. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys. 2004;430:97-103.
Ghaemi-Oskouie F, Shi Y. The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr Rheumatol Rep. 2011;13:160-6.
Jung SW, Kim SM, Kim YG, Lee SH, Moon JY. Uric acid and inflammation in kidney disease. Am J Physiol Ren Physiol. 2020;318:F1327-40.
Ndrepepa G. Uric acid and cardiovascular disease. Clin Chim Acta. 2018;484:150-63.
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006; 440:237-41.
Hughes MM, O’Neill LAJ. Metabolic regulation of NLRP3. Immunol Rev. 2018;281:88-98.
Thompson J, Lakhani N. Cataracts. Prim Care. 2015;42:409-23.
Mirsamadi M, Nourmohammadi I. Correlation of human age-related cataract with some blood biochemistry constituents. Ophthalmic Res. 2003; 35(6):329-34.
Donnelly CA, Seth J, Clayton RM, Phillips CI, Cuthbert J. Some plasma constituents correlate with human cataract location and nuclear colour. Ophthalmic Res. 1997;29(4):207-17.
Liu YT, Hung TY, Lee YK, Huang MY, Hsu CY, Su YC. Association between Chronic Kidney Disease and Risk of Cataract: A Nationwide Retrospective Cohort Study. Am J Nephrol. 2017;45(6):524-31.
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