Combination therapy in the treatment of Stevens-Johnson syndrome/toxic epidermal necrolysis: a case series and review of literature

Soumi Biswas; Arun Achar; Chinmay Bera; Adityendu Chakraborty; Mahasweta Ghosh; Monika Kumari

doi:10.18203/2320-6012.ijrms20240849

Authors

Soumi Biswas Department of Dermatology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
Arun Achar Department of Dermatology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
Chinmay Bera Department of Dermatology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
Adityendu Chakraborty Department of Dermatology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
Mahasweta Ghosh Department of Dermatology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India
Monika Kumari Department of Dermatology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20240849

Keywords:

SJS, TEN, Cyclosporine, Corticosteroid, SCORTEN

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening disease of skin and mucous membrane that are mostly caused by drugs. Many studies have focussed on treatment that modify immunologic responses like corticosteroid, IVIG, cyclosporine, biologics like TNF-α inhibitors etanercept, infliximab etc. But there are few studies available on using two immunomodifier drugs simultaneously. However, no standardized treatment protocol has been established for SJS/TEN patients. We present a case-series of 10 SJS-TEN patients treated with both systemic corticosteroid and cyclosporine. We provide a review of literature on individual systemic corticosteroid, cyclosporine and also simultaneous use of both agents for SJS/TEN, including various outcome measures-stabilization, mortality rate, hospital length of stay and comparison to other systemic agents.

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