Sporotrichoid cutaneous leishmaniasis: atypical form
DOI:
https://doi.org/10.18203/2320-6012.ijrms20240853Keywords:
Cutaneous leishmaniasis, Sporotrichoid leishmaniasis, Treatment, Liposomal amphotericin BAbstract
Leishmaniasis comprises a heterogeneous and extensive group of infectious and non-contagious diseases caused by protozoa of the genus Leishmania spp. It is a disease considered endemic in 92 countries, with at least 1 million new cases of integumentary forms annually. Cutaneous leishmaniasis is endemic in the tropics and neotropics. It is often referred to as a group of diseases because of the varied spectrum of clinical manifestations, which range from small cutaneous nodules to gross mucosal tissue destruction. Cutaneous leishmaniasis can be caused by several Leishmania spp. and is transmitted to human beings and animals by sandflies. Despite its increasing worldwide incidence, because it is rarely fatal, cutaneous leishmaniasis has become one of the so-called neglected diseases, In endemic countries, diagnosis is often made clinically and, if possible, by microscopic examination of lesion biopsy smears to visually confirm leishmania parasites as the cause. Cutaneous leishmaniasis often presents as an ulcerated lesion, with raised, infiltrated edges, classically described as frame-like edges at the site of the mosquito bite. We report an uncommon case of a patient who presented with a lesion on the face, sporotrichoid in appearance, and thigh, which appeared simultaneously, of clinical lesions of cutaneous leishmaniasis, laboratory-confirmed and which showed excellent clinical evolution with the use of liposomal amphotericin B.
References
Vera-Izaguirre D, Vega-Memije E, Quintanilla Cedillo M, et al.: Leishmaniasis revisión. DCMQ. 2006;4(4):252-60.
Torres-Guerrero E, Quintanilla-Cedillo MR, Ruiz-Esmenjaud J, Arenas R. Leishmaniasis: a review F1000 Res. 2017;6:750
Andrade-Narváez FJ, Vargas-González A, Canto-Lara SB, Damián-Centeno AG. Clinical picture of cutaneous leishmaniases due to Leishmania (Leishmania) mexicana in the Yucatan peninsula, Mexico. Mem Inst Oswaldo Cruz. 2001;96(2):163-7.
Reithinger R, Dujardin J, Louzir H, Pirmez C, Alexander B, Brooker S, et al. Cutaneous leishmaniasis. Lancet Infect Dis. 2007;7(9):581-96.
Albertos-Alpuche N. Vectores de la leishmaniasis cutánea en México. Rev Biomed. 1990;1(2):92-102.
Miranda O, González I. Leishmaniasis cutánea. Presentación de casos. Rev Cub Med Mil. 2007:36(4); 51-4.
Cruz Ruiz AL, García-Miss MR. Leishmaniasis: a review. Rev Biomed. 1990;1(2):103-8.
Gontijo B, de Carvalho ML. American cutaneous leishmaniasis. Rev Soc Bras Med Trop. 2003;36(1):71-80.
Jirmanus L, Glesby MJ, Guimarães LH, Lago E, Rosa ME, Machado PR, et al. Epidemiological and clinical changes in American tegumentary leishmaniasis in an area of Leishmania (Viannia) braziliensis transmission over a 20-year period. Am J Trop Med Hyg. 2012;86(3):426-33.
Gontijo B, Guerra JA, Talhari S, Paes MG, Garrido M, Talhari JM. Clinical and diagnostic aspects of American tegumentary leishmaniosis in soldiers simultaneously exposed to the infection in the Amazon Region. Rev Soc Bras Med Trop. 2003;36(5):587-90.
Machado P, Araújo C, Da Silva AT, Almeida RP, D'Oliveira A, Bittencourt A, et al. Failure of early treatment of cutaneous leishmaniasis in preventing the development of an ulcer. Clin Infect Dis. 2002;34(12):69-73.
Barral A, Barral-Netto M, Almeida R, de Jesus AR, Júnior G, Netto EM, et al. Lymphadenopathy associated with Leishmania braziliensis cutaneous infection. Am J Trop Med Hyg. 1992;47(5):587-92.
Carvalho LMV, Pimentel MIF, Conceição-Silva F, Vasconcellos ÉCFE, Valete-Rosalino CM, Lyra MR, et al. Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil. Rev Inst Med Trop Sao Paulo. 2017;59:33.
Murray HW, Berman JD, Davies CR, Saravia NG. Advances in leishmaniasis. Lancet. 2005;366(9496):1561-77.
Ramírez JR, Agudelo S, Muskus C, Alzate JF, Berberich C, Barker D, et al. Diagnosis of cutaneous leishmaniasisin Colombia: the sampling site within lesions influences the sensitivity of parasitologic diagnosis. J Clin Microbiol. 2000;38(10):3768-73.
Cordova-Uscanga C, Albertos-Alpuche NE, Andrade-Narvaez FJ, Canto-Lara SB. Leishmaniasis: preliminary epidemiological study in a locality in the endemic area of the state of Tabasco. Salud Publica Mex. 1993;35(4):345-50.
Alpuche N, Narváez A, Burgos Patrón J. Leishmaniasis. Rev Biomed. 1996;7(1):11-8.
Bravo F, Sanchez MR. New and re-emerging cutaneous infectious diseases in Latin America and other geographic areas. Dermatol Clin. 2003;21(4):655-68,
Kevric I, Cappel MA, Keeling JH. New world and old world leishmania infections: a practical review. Dermatol Clin. 2015;33(3):579-93.
Antinori S, Schifanella L, Corbellino M. Leishmaniasis: new insights from an old and neglected disease. Eur J Clin Microbiol Infect Dis 2012;31:109-18.
Silveira FT, Lainson R, Corbett CEP. Clinical and immunopathological spectrum of American cutaneous leishmaniasis with special reference to the disease in Amazonian Brazil: a review. Mem Inst Oswaldo Cruz. 2004;99(3):239-51.
Bailey MS, Lockwood DN. Cutaneous leishmaniasis. Clin Dermatol. 2007;25(2):203-11.
Goto H, Lindoso JA. Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Rev Anti Infect Ther. 2010;8(4):419-33.
Hosseinzadeh M, Omidifar N, Lohrasb MH. Use of fine needle aspiration cytology in the diagnosis of cutaneous leishmaniasis: a comparison with the conventional scraping method. Trop Doct. 2012;42(2):112-3.
Boggild AK, Miranda-Verastegui C, Espinosa D, Arevalo J, Martinez-Medina D, Llanos-Cuentas A, et al. Optimization of microculture and evaluation of miniculture for the isolation of Leishmania parasites from cutaneous lesions in Peru. Am J Trop Med Hyg. 2008;79(6):847-52.
Reithinger R, Dujardin JC. Molecular diagnosis of leishmaniasis: current status and future applications. J Clin Microbiol. 2007;45(1):21-5.
Cruz I, Millet A, Carrillo E, Chenik M, Salotra P, Verma S, et al. An approach for interlaboratory comparison of conventional and real-time PCR assays for diagnosis of human leishmaniasis. Exp Parasitol. 2013;134(3):281-9.
Carvalho LMV, Pimentel MIF, Conceição-Silva F, Vasconcellos ÉCFE, Valete-Rosalino CM, Lyra MR, et al. Sporotrichoid leishmaniasis: a cross-sectional clinical, epidemiological and laboratory study in Rio de Janeiro State, Brazil. Rev Inst Med Trop Sao Paulo. 2017;59(1):38.