Efficacy of Ayurved based therapy on global longitudinal strain in ischemic heart disease: a retrospective analysis

Authors

  • Rohit Sane Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India
  • Pravin Ghadigaonkar Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India
  • Gaurav Shelke Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India
  • Raghvendra Pratap Singh Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India
  • Nilesh Kulthe Madhavbaug Cardiac Clinic and Hospital, Thane, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20241246

Keywords:

Ayurveda, Ischemic heart disease, Panchakarma

Abstract

Background: The current study aimed to investigate the efficacy of the Ischemia Reversal program (IRP) as an Ayurveda based therapy to standard anti-ischemic therapy in patients with ischemic heart disease (IHD).

Methods: A retrospective, single centre, observational study was conducted from January 2022 to May 2023. A total of 39 patients diagnosed with ischemic heart disease and global longitudinal strain (GLS) <15, regardless of underlying co-morbidities such as diabetes mellitus, hypertension, obesity, hyperlipidemia, low ejection fraction, history of myocardial infarction were included in this study. The primary endpoint was improvement in GLS from baseline to the 90-day follow-up in various different categories. Secondary endpoints were improvement in EF, abdominal girth, weight and reduction in dependency on allopathic medication from baseline to the 90-day follow-up.

Results: The mean age of the study population was 59.23±9.01 years. Weight (day 1: 67.29±13.16 kg and day 90: 61.39±11.11 kg; p=0.00), body mass index (day 1: 25.75±4.03 and day 90: 23.79±3.50; p=0.00), abdominal girth (day 1: 95.31±10.75 cm and day 90: 85.67±17.02 cm p=0.00), EF (day 1: 40.74±10.30% and day 90: 53.91±11.87%; p=0.00), and GLS (day 1: -10.99±2.72 and day 90: -13.17±3.75; p=0.00) improved at the 90 day follow-up.

Conclusions: The study showed notable improvements in weight, body mass index, abdominal girth, EF, and GLS after 90 days. These results suggest that IRP is beneficial treatment for IHD, but more extensive research is needed to confirm its effectiveness.

References

Gupta R, Gaur K. Epidemiology of ischemic heart disease and diabetes in south Asia: an overview of the twin epidemic. Curr Diabetes Rev. 2021;17(9):e100620186664.

Mandole R, Amin G, Ghadigaonkar P, Narang R. Study of the efficacy of Ischemia Reversal Program along with restricted diet in an elderly myocardial ischemic patient with a known history of hypertension - A case study. Int J Ayurv Pharma Res. 2023;11(4):79-82

Sane R, Sugwekar V, Nadapude A, Hande A, Depe G, Mandole R. Study of efficacy of ischemia reversal program (IRP) in ischemic heart disease (IHD) patients with VO2max and Duke’s treadmill score. Int J Basi Clin Pharmacol. 2018;7(8):1642-7.

Sane R, Gond B, Raje G, Walzade K, Badre A, Mandole R. Ischemia Reversal Program (IRP) in patients suffering from ischemic heart disease (IHD) with known history of hypertension: A retrospective study. J Ayurv Medi Sci. 2018;3(2):377-83.

Sane R, Ghadigaonkar P, Kharat A, Yadav SK, Mahajan S, Mandole R. Efficacy of Ischemia Reversal Program (IRP) in elderly patients of ischemic heart disease with known history of hypertension. Asian J Cardio Res. 2018;1(1):1-8.

Sane R, Mandole R. Pilot open label single arm efficacy study of Ischemia Reversal Program as add-on therapy to conventional treatment in patients with stable ischemic heart disease. J Heart Health. 2016;2(3).

General Assembly of the World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. J Am Coll Dent. 2014; 81(3):14-8.

Dixon JR Jr. The International Conference on Harmonization Good Clinical Practice guideline. Qual Assur. 1998;6(2):65-74.

Zito C, Longobardo L, Citro R, Galderisi M, Oreto L, Carerj ML, et al. Ten years of 2D longitudinal strain for early myocardial dysfunction detection: a clinical overview. Biomed Res Int. 2018;2018:8979407.

Krishnasamy R, Isbel NM, Hawley CM, Pascoe EM, Burrage M, Leano R, et al. Left Ventricular Global Longitudinal Strain (GLS) is a superior predictor of all-cause and cardiovascular mortality when compared to ejection fraction in advanced chronic kidney disease. PLoS One. 2015;10(5):e0127044.

Sane R, Manohar P, Mandole R, Amin G, Ghadigaonkar P, Patil D, et al. Impact of Ayurveda-based ischemia reversal program on reduction of resting myocardial ischemia studied with speckle-tracking global longitudinal strain imaging. J Ind Coll Cardiol. 2022;12(3):106-10.

Sane R, Manohar P, Mandole R, Amin G, Patil D, Ghadigaonkar P, et al. Impact of Ayurveda based ischemia reversal program (IRP) and polyherbal medication on reduction of resting myocardial ischemia with speckle tracking global longitudinal strain imaging in type 2 diabetes mellitus patients. Int J Innovat Res Medi Sci. 2022;7(8):416-9.

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Published

2024-04-30

How to Cite

Sane, R., Ghadigaonkar, P., Shelke, G., Singh, R. P., & Kulthe, N. (2024). Efficacy of Ayurved based therapy on global longitudinal strain in ischemic heart disease: a retrospective analysis. International Journal of Research in Medical Sciences, 12(5), 1588–1593. https://doi.org/10.18203/2320-6012.ijrms20241246

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Original Research Articles