Borderline mucinous ovarian tumour – a rare bilateral presentation

Authors

  • Jayawant W. Mahadani Department of Pathology, SVNGMC Yavatmal, Maharashtra, India
  • Surabhi S. Kulkarni Department of Pathology, SVNGMC Yavatmal, Maharashtra, India
  • Nilima D. Lodha Department of Pathology, SVNGMC Yavatmal, Maharashtra, India
  • Nigar Fatema M. Khan Department of Pathology, SVNGMC Yavatmal, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20164245

Keywords:

Borderline, Intestinal type, Mucinous, Mullerian type, Ovarian

Abstract

Surface epithelial tumours are the most common ovarian tumours. According to the cell type, surface epithelial tumours can be serous, mucinous, endometrioid etc. Mucinous tumours of ovary are the neoplasms characterized by glandular, cystic architecture and are lined to variable extents by mucin-containing epithelium. Further these tumours are sub-classified into benign, borderline and malignant category. Typically, borderline tumours are non-invasive neoplasms that have nuclear abnormalities and mitotic activity intermediate between benign and malignant tumours of similar cell type. Borderline ovarian tumours are clinical entities less frequently encountered by pathologists and gynaecologists. Mucinous borderline ovarian tumours are among the most difficult ovarian neoplasms for surgical pathologists to interpret. They occur in younger women and present at an early stage. However, borderline tumours are difficult to diagnose correctly preoperatively using imaging methods because their macroscopic features overlap with invasive and benign ovarian tumours. Most importantly, these tumours have a superior prognosis when compared with ovarian carcinomas stage for stage. The borderline tumours may be of intestinal type or mullerian (endocervical like) type. The intestinal type tumours are by far the most common. Approximately 5% of the borderline mucinous tumours are bilateral. We here report a rare case of bilateral borderline mucinous tumours diagnosed on histopathology.

References

Exacoustos C, Romanini ME, Rinaldo D, Amoroso C, Szabolcs B, Zupi E, et al. Preoperative sonographic features of borderline ovarian tumours. Ultrasound Obstet Gynecol. 2005;25(1):50-9.

Fattaneh TA, Peter D. WHO. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon: IARC Press; 2003;2:125-6.

Taylor Jr HC. Malignant and semi-malignant tumours of the ovary. Surg Gynecol Obstet. 1929;48:204-30.

Fisher ER, Krieger JS, Skirpan PJ. Ovarian cystoma. Clinicopathological observations. Cancer. 1955;8:437-45.

FIGO. International Federation of Gynaecology and Obstetrics. Classification and staging of malignant tumours in the female pelvis. Acta Obstet Gynecol Scand. 1971;50:1-7.

Serov SF, Scully RE, Sobin LH. International Histologic Classification of Tumours. No. 9. Histological Typing of Ovarian Tumours. World Health Organization: Geneva. 1973.

Scully RE, Sobin LH. Histologic Typing of Ovarian Tumors, 2nd edn. In: World Health Organization International Histological Classification of Tumors. Springer-Verlag: Berlin, Heidelberg. 1999.

Hart WR, Norris HJ. Borderline and malignant mucinous tumours of the ovary. Histologic criteria and clinical behavior. Cancer. 1973;31:1031-45.

Hart WR. Ovarian epithelial tumours of borderline malignancy (carcinomas of low malignant potential). Hum Pathol. 1977;8:541-9.

Ronnett BM, Kurman RJ, Zahn CM, Shmookler BM, Jablonski KA, Kass ME, et al. Pseudomyxoma peritonei in women: a clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumours of low malignant potential. Hum Pathol. 1995;26:509-24.

Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH. Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases. Am J Surg Pathol. 2003;27:1089-103.

Paulsen T, Kaern J, Kjaerheim K, Tropé C, Tretli S. Symptoms and referral of women with epithelial ovarian tumours. Int J Gynaecol Obstet. 2005;88(1):31-7.

Gotlieb WH, Soriano D, Achiron R, Zalel Y, Davidson B, Kopolovic J, et al. CA 125 measurement and ultrasonography in borderline tumours of the ovary. Am J Obstet Gynecol. 2000;183(3):541-6.

Engelen MJ, de Bruijn HW, Hollema H, ten Hoor KA, Willemse PH, Aalders JG, et al. Serum CA 125, carcinoembryonic antigen, and CA 19-9 as tumour markers in borderline ovarian tumours. Gynecol Oncol. 2000;78:16-20.

Tinelli R, Tinelli A, Tinelli FG, Cicinelli E and Malvasi A. Conservative surgery for borderline ovarian tumours: a review. Gynecol Oncol. 2006;100:185-91.

Trope CG, Kristensen G, Makar A. Surgery for borderline tumour of the ovary. Semin Surg Oncol. 2000;19:69-75.

Downloads

Published

2016-12-16

How to Cite

Mahadani, J. W., Kulkarni, S. S., Lodha, N. D., & Khan, N. F. M. (2016). Borderline mucinous ovarian tumour – a rare bilateral presentation. International Journal of Research in Medical Sciences, 4(12), 5516–5518. https://doi.org/10.18203/2320-6012.ijrms20164245

Issue

Section

Case Reports