Efficacy of educational campaign on human leucocyte antigens screening for stem cell donation
DOI:
https://doi.org/10.18203/2320-6012.ijrms20244104Keywords:
Effectiveness, HLA, Knowledge, Immunological response, Screening, Stem cells, Stem cell donationAbstract
Background: Nearly all cells express the proteins known as human leukocyte antigens, or HLA. They aid in distinguishing our own cells from foreign substances and are principally in charge of the body's immunological response. It's interesting to note that every person inherits a distinct collection of antigens from their parents, with half coming from the mother and the other half from the father. This implies that these options can be programmed into youngsters from birth. This study aimed to evaluate how well undergrad students in particular colleges in greater Noida, Uttar Pradesh, are informed about HLA screening for stem cell donation.
Methods: Using convenience sample techniques, a pre-experimental study design is used to evaluate the awareness programme on HLA screening for stem cell donation.
Results: According to the study's findings, the majority of the sample (84%) had poor knowledge of stem cell donation during the pre-test, 16.0% had average knowledge, and 0% had good knowledge. During the post-test, however, the majority (61.0%) had good knowledge, with around 30.0% having average knowledge and only 9.0% having poor knowledge.
Conclusions: In summary, the majority of participants had low pre-test knowledge of HLA and stem cell donation; but, following an awareness presentation on the subject, most of them performed well on the post-test and had good understanding about HLA, DKMS, and stem cell donation. The awareness campaign was a success all around, and some of the participants are even eager to give.
Metrics
References
Niederwieser D, Baldomero H, Atsuta Y, Aljurf M, Seber A, Greinix HT, Koh M, Worel N, Galeano S, Jaimovich G, Rolon JM, et al. One and Half Million Hematopoietic Stem Cell Transplants (HSCT). Dissemination, Trends and Potential to Improve Activity by Telemedicine from the Worldwide Network for Blood and Marrow Transplantation (WBMT). Blood. 2019;134(Supplement_1):2035.
AlAbdulqader AA, AlMulhim AM, AlMulhim FF, Almubarak HHA. Knowledge and attitude of blood, organ and stem cells donation among AlAhssa population. Int J Acad Scient Res. 2017;5:40-53.
Alhadlaq A, Al-Maflehi N, Alzahrani S, AlAssiri A. Assessment of knowledge and attitude toward stem cells and their implications in dentistry among recent graduates of dental schools in Saudi Arabia. The Saudi Dent J. 2019;31(1):66-75.
Tiercy JM. How to select the best available related or unrelated donor of hematopoietic stem cells? Haematol. 2016;101(6):680-7.
Lye JL, Soon LK, Ahmad WA, Tan SC. Knowledge and attitude about stem cells and their application in medicine among nursing students in Universiti Sains Malaysia, Malaysia. MJMS. 2015;22(4):23.
MayoClinic. MayoClinic Stem cells: frequently asked questions about stem cell research, 2019. Available at: https://www.mayoclinic.org/tests-procedures/bone-marrow-transplant/in-depth/stem-cells/art-20048117. Accessed 26 October 2020.
Muraro PA, Pasquini M, Atkins HL, Bowen JD, Farge D, Fassas A, et al. Long-term outcomes after autologous hematopoietic stem cell transplantation for multiple sclerosis. JAMA Neurol. 2017;74(4):459-69.
Almaeen A, Wani FA, Thirunavukkarasu A. Knowledge and attitudes towards stem cells and the significance of their medical application among healthcare sciences students of Jouf University. Peer J. 2021;9:e10661.
Ariza-Heredia EJ, Gulbis AM, Stolar KR, Kebriaei P, Shah DP, McConn KK, et al. Vaccination guidelines after hematopoietic stem cell transplantation: practitioners' knowledge, attitudes, and gap between guidelines and clinical practice. Transpl Infect Dis. 2014;16(6):878-86.
Fernandes DR, Braga FTMM, Silveira RCCP, Garbin LM. Hand hygiene: knowledge and skill of caregivers in the hematopoietic stem cell transplantation. Rev Bras Enferm. 2019;72(6):1653-62.
ALtemani MF, ELBeltagy M, ALmashori MM, ALaradi BI, majed ALtoairqi L, Swead FA, et al. Knowledge, attitude and practice of doctors and medical students towards stem cell use in the management of diabetes mellitus. Egyp J Hosp Medi. 2018;71(6):3308-13.
Rucinski D, Jones R, Reyes B, Tidwell L, Phillips R, Delves D. Exploring opinionsand beliefs about cord blood donation among Hispanic and non‐Hispanic blackwomen. Transfusion. 2010;50(5):1057-63.
Weiss ML, Troyer DL. Stem cells in the umbilical cord. Stem cell reviews. 2006;2(2):155-62.
Gluckman E, Broxmeyer HE, Auerbach AD, Friedman HS, Douglas GW, Devergie A, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. 1989:321-17.
Azzazy MH, Mohamed FH. Effect of educational intervention on knowledge and attitude of nursing students regarding stem cells therapy. IOSR. 2016;5(2):75-80.
Dimarakis I, Habib NA, Gordon MY. Adult bone marrow-derived stem cells and the injured heart: just the beginning? Europ J Cardio-Thor Surg. 2005;28(5):665-76.
Maiers M, Halagan M, Joshi S, Ballal HS, Jagannatthan L, Damodar S, et al. HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: a population-based study. Lancet Haematol. 2014;1(2):e57-e63.
National Institutes of Health. National Institutes of Health Stem cell basics, 2019. Available at: https://stemcells.nih.gov/info/basics/stc-basics. Accessed 13 September 2019.
Almaeen A, Wani FA, Thirunavukkarasu A. Knowledge and attitudes towards stem cells and the significance of their medical application among healthcare sciences students of Jouf University. PeerJ. 2021;9:e10661.
Downloads
Published
How to Cite
Issue
Section
