Association between pre-operative high sensitive C-reactive protein and immediate post-operative radicular pain following prolapsed lumbar intervertebral disc surgery

K. Olinur Razib; Asifur Rahman; Mohammad Farid Raihan; Mohammad Shahnawaz Bari; M. Ataur Rahman; Tayeb Ahmmed; Kazi Saiful Islam; Muhammad Saiful Islam; M. Abdur Rahim; Kanij Fatima; Haradhan Deb Nath

doi:10.18203/2320-6012.ijrms20241529

Authors

K. Olinur Razib Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Asifur Rahman Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Mohammad Farid Raihan Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Mohammad Shahnawaz Bari Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
M. Ataur Rahman Department of Neurosurgery, National Institute of Neuro Sciences & Hospital, Dhaka, Bangladesh
Tayeb Ahmmed Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
Kazi Saiful Islam Department of Neurosurgery, Directorate General of Health Services (DGHS), Mohakhali, Dhaka, Bangladesh
Muhammad Saiful Islam Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh
M. Abdur Rahim Department of Neurosurgery, Directorate General of Health Services (DGHS), Mohakhali, Dhaka, Bangladesh
Kanij Fatima Department of Prosthodontics, Liberty Hospital (Pvt) Ltd., Dhaka, Bangladesh
Haradhan Deb Nath Department of Neurosurgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20241529

Keywords:

Biomarker, C-reactive protein, Low back pain, Lumber intervertebral disc, VAS score

Abstract

Background: Nerve root compression is often inadequately understanding radicular pain due to prolapsed lumbar intervertebral disc, a common neurosurgical presentation. Inflammation is proved as an important etio-pathological component of radiculopathy, even after surgery.

Methods: This cross-sectional intervention study conducted from March 2022 to September 2023. Data collected from 45 patients with prolapsed lumber intervertebral Disc, who underwent surgical intervention in Department of Neurosurgery, BSMMU.

Results: The mean±SD age of the patients was 38.4±11.6 years, most of them 37 (82.2%) aged within 29 to 60 years. Majority 30 (66.7%) of them were male. Patients presented with pain, numbness and weakness was 45 (100%), 33 (73.3%) and 8 (17.8%) respectively. Among the participants most 36 (80%) had right sided and 9 (20%) had left sided radiation. The mean±SD level of pre-operative high sensitive C-reactive protein was 2.1±1.7. Pre-operative high sensitive C-reactive protein was significantly associated pre-operative, post-operative and mean change in visual analogue score (p<0.001, p<0.001, p= 0.006 respectively). Correlation of high sensitive C-reactive protein and VAS score (both pre and post-operative) were also statistically significant with p =0.017 and p <0.001 respectively.

Conclusions: In our study, there is an association between pre-operative serum high sensitive C- reactive protein and post-operative radicular pain following surgical intervention in patients with prolapsed lumbar intervertebral disc.

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