A case study of post traumatic meningitis after a road traffic accident
DOI:
https://doi.org/10.18203/2320-6012.ijrms20241923Keywords:
Road traffic accident, CSF rhinorrhoea, K. pneumoniae, MeningitisAbstract
In road traffic accident cases one of the main reasons for hospitalization is traumatic brain injury (TBI) with subdural hematomas (SDH). The in-hospital course is further complicated by variety of infections including meningitis. A significant concern in the field of bacterial resistance is the multidrug-resistant strain of K. pneumoniae. Due to the dearth of therapeutic options, treating K. pneumoniae infections can be difficult and have an adverse impact on morbidity, mortality, and healthcare-related expenses. Here, we present the case of a 34-year-old polytrauma patient who was in good physical health prior to the road traffic accident. The patient sustained right fronto temporo parietal SDH, frontal contusion, frontal bone fracture, multiple facial bone fracture and CSF rhinorrhoea. He underwent bifrontal craniotomy and ACF repair on the following day. His in-hospital course was complicated by Klebsiella meningitis. He was discharged from the hospital after 25 days of successful treatment of meningitis. In the present study, effective and satisfactory results were achieved through antibiotic therapy which included Colistin IV and intrathecal, Fosfomycin IV, and Tigecycline IV, for a post-operative K. pneumoniae infection. On review day, the CSF analysis had revealed total leucocyte count of 9 and CSF showed no growth.
Metrics
References
Matar ZS. The clinical profile of poly trauma and management of abdominal trauma in a general hospital in the central region of the kingdom of Saudi Arabia. The Internet J Surg. 2008;14(2):1-5.
Maxeiner H, Wolff M. Pure subdural hematomas: a postmortem analysis of their form and bleeding points. Neurosurg. 2007;61(1):267-72.
Emanuelli E, Milanese L, Rossetto M, Cazzador D, D’Avella E, Volo T, et al. The endoscopic endonasal approach for cerebrospinal fluid leak repair in the elderly. Clini Neurol Neurosurg. 2015;132:21-5.
Jill D, Dana W, Kelly S, Likang X. Traumatic brain injury-related deaths by race/ethnicity, sex, intent, and mechanism of injury-United States, 2000-2017. Morb Mort Weekly Rep. 2019;68(46):1050-6.
Chan KS, Yu WL, Tsai CL, Cheng KC, Hou CC, Lee MC, et al. Pyogenic liver abscess caused by Klebsiella pneumoniae: analysis of the clinical characteristics and outcomes of 84 patients. Chin Med J. 2007;120(2):136-9.
Lu CH, Chang WN, Wu HS. Klebsiella pneumoniae meningitis: analysis on clinical features of thirty-two adult patients. Chin Med J (Taipei). 1997;60(6):296-302.
Bagley ST. Habitat association of Klebsiella species. Infect. Control 1985;6(2):52-8.
Qin J, Qiu Y, Guo S, Li M, Lin F, Wan R, et al. Distribution and antimicrobial resistance profile of Klebsiella pneumoniae. Chin J Infec Chemother. 2017;6:269-72.
Iredell J, Brown J, Tagg K. Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications. BMJ. 2016;352:h6420.
Alexiou VG, Michalopoulos A, Makris GC, Peppas G, Samonis G, Falagas ME. Multi-drug resistant gram negative bacterial infection in surgical patients hospitalized in the ICU: a cohort study. Eur J Clin Microbiol Infect Dis. 2012;31(4):557-66.
Mathias T, Levy J, Fatakia A, McCoul ED. Contemporary approach to the diagnosis and management of cerebrospinal fluid rhinorrhea. Ochsner J 2016;16(2):136-42.
Lee JJ, Kim HY, Dhong HJ, Chung SK, Kong DS, Nam DH, et al. Delayed cerebrospinal fluid leakage after treatment of skull base tumors: case series of 9 patients. World Neurosurg. 2019;132:e591‐8.
Muringaseril PSC, Rufibach K, Ruef C, Holzmann D, Soyka MB. Low meningitis incidence in primary spontaneous compared to secondary cerebrospinal fluid rhinorrhoea. Rhin. 2012;50(1):73‐9.
Friedman JA, Ebersold MJ, Quast LM. Post‐traumatic cerebrospinal fluid leakage. World J Surg. 2001;25(8):1062-6.
Tallon JM, Ackroyd-Stolarz S, Karim SA, Clarke DB. The epidemiology of surgically treated acute subdural and epidural hematomas in patients with head injuries: a population based study. Can J Surg. 2008;51(5):339-45.
Rabinstein AA. Paroxysmal sympathetic hyperactivity in the neurological intensive care unit. Neurol Res. 2007;29(7):680-2.
Emrullah CK, Zafer Y. Frontal sinus repair after bifrontal craniotomy: a single center experience. J Experi Clini Med. 2023;40(2):337-40.
Panneerselvam E, Balasubramanian S, Kempraj J, Babu VR, Raja VBKK. Management of Zygomatic Arch Fractures by Intraoral Open Reduction and Transbuccal Fixation: A Technical Note. Craniomaxillofac Trauma Reconstr. 2020;13(2):130-2.
Patil AJ, Tolat T, Yelikar A, Kulkarni J. Incidence and management of zygomatico maxillary complex fractures treated at Mahatma Gandhi Mission Hospital, Aurangabad, Maharashtra. Int J Curr Med App Sci. 2019;22(2):11-5.
Ryan Arnold S, Kerri Thom A, Saarika Sharma, Michael P, Kristie JJ, Daniel MJ. Emergence of Klebsiella pneumoniae Carbapenemase (KPC) producing bacteria. South Med J 2011;104(1):40-5.
Rosen RD, Manna B. Wound Dehiscence. Stat Pearls Publishing; Treasure Island (FL). 2020.
Le P, Martinez R, Black J. Frontal sinus fracture management meta-analysis: endoscopic versus open repair. J Cranio fac Surg. 2021;32(4):1311-5.
Shakir S, Card EB, Kimia R, Greives MR, Nguyen PD. Anterior cranial base reconstruction in complex craniomaxillofacial trauma: An algorithmic approach and single surgeon's experience. Arch Plast Surg. 2022;49(2):174-83.
Yan W, Xiati G, Yihan R, Lingli Y, Peng W. Clinical analysis of nosocomial infections due to intracranial surgery (in Chinese). Chin J Nosocomio. 2012;22:4011-3.
Yee-Huang K, Yin-Ching C, Chi-Chung C, Mei-Feng L, Yan-Chang Y, Hung-Jen T, et al. Klebsiella pneumoniae isolates from Meningitis: Epidemiology, virulence and antibiotic resistance. Sci Rep. 2017;7:6634.
Virgilio E, Castaldo P, Catta F, Tarantino G, Cavallini M. Abdominal surgical site infection due to Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Int Wound J 2016;13(5):1075-6.
Sękowska A, Gospodarek E. Susceptibility of Klebsiella spp. to tigecycline and other selected antibiotics. Med Sci Monit. 2010;16(6):193-6.