Assessing the prevalence of hypocalcemia after total thyroidectomy at a tertiary care hospital
DOI:
https://doi.org/10.18203/2320-6012.ijrms20241891Keywords:
Hypocalcemia, Postoperative complications, Thyroid surgery, ThyroidectomyAbstract
Background: Thyroidectomy is a common surgical procedure for various thyroid disorders, but it often leads to complications such as hypocalcemia. Understanding the prevalence and predictors of hypocalcemia post-total thyroidectomy is crucial for improving patient outcomes.
Methods: This prospective cross-sectional study was conducted at a tertiary care hospital with 100 patients undergoing thyroid surgery, including total thyroidectomy, completion thyroidectomy, and thyroidectomy with neck dissection. We analyzed the incidence of transient and permanent hypocalcemia, examining correlations with surgery type, demographic variables, and postoperative day of onset. Data were collected through patient records and postoperative follow-ups.
Results: The study revealed that 30% of patients experienced hypocalcemia postoperatively. Hypocalcemia was most prevalent among patients undergoing thyroidectomy with neck dissection (58.33%), compared to those undergoing total thyroidectomy (18.18%) and completion thyroidectomy (40.00%). The majority of hypocalcemia cases (66.67%) occurred on the second postoperative day. Most hypocalcemia instances were transient (86.67%), with a smaller fraction being permanent (13.33%).
Conclusions: Hypocalcemia remains a significant complication following thyroid surgery, particularly in surgeries involving neck dissection. Early identification and management of at-risk patients could mitigate the severity of this complication. Our findings underscore the importance of vigilant monitoring and tailored postoperative care to minimize the impact of hypocalcemia on patient recovery and quality of life.
Metrics
References
Delbridge L. Total thyroidectomy: the evolution of surgical technique. ANZ J Surg. 2003;73(9):761-8.
Serpell JW, Phan D. Safety of total thyroidectomy. ANZ J Surg. 2007;77(1–2):15-9.
Sephton BM. Extracervical approaches to thyroid surgery: evolution and review. Minim Invasive Surg. 2019;2019:5961690.
Ludwig B, Ludwig M, Dziekiewicz A, Mikuła A, Cisek J, Biernat S, et al. Modern surgical techniques of thyroidectomy and advances in the prevention and treatment of perioperative complications. Cancers (Basel). 2023;15(11):2931.
Efremidou EI, Papageorgiou MS, Liratzopoulos N, Manolas KJ. The efficacy and safety of total thyroidectomy in the management of benign thyroid disease: a review of 932 cases. Can J Surg. 2009;52(1):39-44.
Raval MV, Browne M, Chin AC, Zimmerman D, Angelos P, Reynolds M. Total thyroidectomy for benign disease in the pediatric patient-feasible and safe. J Pediat Surg. 2009;44(8):1529-33.
Puzziello A, Rosato L, Innaro N, Orlando G, Avenia N, Perigli G, et al. Hypocalcemia following thyroid surgery: incidence and risk factors. A longitudinal multicenter study comprising 2,631 patients. Endocrine. 2014;47(2):537-42.
Qin Y, Sun W, Wang Z, Dong W, He L, Zhang T, et al. A meta-analysis of risk factors for transient and permanent hypocalcemia after total thyroidectomy. Fronti Oncol. 2021;10:614089.
Hinson AM, Stack BC. Applied embryology, molecular genetics, and surgical anatomy of the Parathyroid Glands. In: Stack Jr Brendan C, Bodenner DL, editors. Medical and Surgical Treatment of Parathyroid Diseases: An Evidence-Based Approach. Cham: Springer International Publishing; 2017:17-25.
Hojaij F, Vanderlei F, Plopper C, Rodrigues CJ, Jácomo A, Cernea C, et al. Parathyroid gland anatomical distribution and relation to anthropometric and demographic parameters: a cadaveric study. Anat Sci Int. 2011;86(4):204-12.
Policeni BA, Smoker WRK, Reede DL. Anatomy and embryology of the thyroid and parathyroid glands. seminars in ultrasound, CT and MRI. 2012;33(2):104-14.
Al- Mahdawi FKI, Hassan AS, Alsiad WAWI. Parathyroid gland, anatom, histology, and physiology (a short review). Bas J Vet Res. 2020;19(1):81-7.
Pattou F, Combemale F, Fabre S, Carnaille B, Decoulx M, Wemeau JL, et al. Hypocalcemia following thyroid surgery: incidence and prediction of outcome. World J Surg. 1998;22(7):718-24.
Chen Y, Masiakos PT, Gaz RD, Hodin RA, Parangi S, Randolph GW, et al. Pediatric thyroidectomy in a high volume thyroid surgery center: risk factors for postoperative hypocalcemia. J Pedia Surg. 2015;50(8):1316-9.
Güllüoğlu BM, Manukyan MN, Cingi A, Yeğen C, Yalın R, Aktan AÖ. Early prediction of normocalcemia after thyroid surgery. World J Surg. 2005;29(10):1288-93.
Raffaelli M, De Crea C, D’Amato G, Moscato U, Bellantone C, Carrozza C, et al. Post-thyroidectomy hypocalcemia is related to parathyroid dysfunction even in patients with normal parathyroid hormone concentrations early after surgery. Surgery. 2016;159(1):78-85.
Seo ST, Chang JW, Jin J, Lim YC, Rha KS, Koo BS. Transient and permanent hypocalcemia after total thyroidectomy: Early predictive factors and long-term follow-up results. Surg. 2015;158(6):1492-9.
Kim JH, Chung MK, Son YI. Reliable early prediction for different types of post-thyroidectomy hypocalcemia. Clin Exp Otorhinolaryngol. 2011;4(2):95-100.