Transient neonatal diabetes mellitus with subtype ZFP57 genetic defect in 6q24

Abeer M. Hekal; Naguib M. Abdel Reheim; Hakam Yaseen; Ayman Elsenwi

doi:10.18203/2320-6012.ijrms20241917

Authors

Abeer M. Hekal Department of Paediatric and Neonatology, University Hospital of Sharjah, Sharjah, United Arab Emirates
Naguib M. Abdel Reheim Department of Paediatric and Neonatology, University Hospital of Sharjah, Sharjah, United Arab Emirates
Hakam Yaseen Department of Paediatric and Neonatology, University Hospital of Sharjah, Sharjah, United Arab Emirates
Ayman Elsenwi Department of Paediatric and Neonatology, University Hospital of Sharjah, Sharjah, United Arab Emirates

DOI:

https://doi.org/10.18203/2320-6012.ijrms20241917

Keywords:

Neonatal, Diabetis mellitus, ZFP57 gene, 6q24 chromosome region

Abstract

Neonatal diabetes (NDM) is a rare form of diabetes that manifests in the first few months of an infant's life. The condition affects approximately one in 300,000 to 400,000 newborns and is characterized by elevated blood glucose levels. Transient and permanent NDM are the two types of this disease. In most cases of transient neonatal diabetes mellitus (TNDM), the genetic cause has been attributed to the overexpression of chromosome 6q24. Regardless of its underlying cause, the primary treatment for neonatal diabetes is insulin therapy.

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