Co-trimoxazole induced Steven Johnson syndrome in HIV infected patient: things to consider

Desak Putu Sukasanti Adi Kunti; Ketut Suryana

doi:10.18203/2320-6012.ijrms20241601

Authors

Desak Putu Sukasanti Adi Kunti Wangaya Regional Hospital, Denpasar, Bali, Indonesia
Ketut Suryana Department of Internal Medicine, Merpati Clinic, HIV and Allergy Clinical Immunology Services Unit, Wangaya Hospital, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.18203/2320-6012.ijrms20241601

Keywords:

People living with HIV/AIDS, Co-trimoxazole, Steven Johnson syndrome

Abstract

Co-trimoxazole is a sulfonamide fixed dose combination antibiotic which is effective and widely use in treatment and prevention of opportunistic infections in people living with HIV/AIDS, but can be potentially associated with adverse drug reactions including drug hypersensitivity reactions such as Steven Johnson syndrome. PLWHA individuals have up to a 1000-fold increased risk of drug hypersensitivity reaction compared to the general population, which is associated with drug exposure, immune dysregulation, and concurrent infections. Here we present a case report of a 59-year-old man with HIV who experienced Stevens-Johnson Syndrome after taking co-trimoxazole for 18 days. Therefore, we would like to remind you to be more careful when giving cotrimoxazole to PLWHA because it can take time for a hypersensitivity reaction to occur, also in a few cases, it can occur immediately.

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