Assessment of serum IgE level in patients with transfusion related allergic reaction receiving fresh frozen plasma

A. H. M. Saik Rahman; Urmi Rahman; Munasib Noor; Aklima Akther Urmi; Masrun Mostafa Chowdhury; Fatma Muzib; Sabrina Huda Nila; Tanzila Tabib Chowdhury

doi:10.18203/2320-6012.ijrms20241865

Authors

A. H. M. Saik Rahman Department of Transfusion Medicine, Ad-din Barrister Rafique-ul Huq Hospital, Dhaka, Bangladesh
Urmi Rahman Department of Transfusion Medicine, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
Munasib Noor Department of Transfusion Medicine, Chittagong Medical College Hospital, Chittagong, Bangladesh
Aklima Akther Urmi Department of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh
Masrun Mostafa Chowdhury Department of Dermatology and Venerology, Ad-din Barrister Rafique-ul Huq Hospital, Dhaka, Bangladesh
Fatma Muzib Department of Transfusion Medicine, Community Based Medical College, Bangladesh
Sabrina Huda Nila Department of Transfusion Medicine, Ad-din Women’s Medical College & Hospital, Dhaka, Bangladesh
Tanzila Tabib Chowdhury Department of Transfusion Medicine, Chittagong Medical College Hospital, Chittagong, Bangladesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20241865

Keywords:

Allergic reaction, Fresh frozen plasma, Pathophysiology, Serum IgE level, Transfusion

Abstract

Background: Blood transfusion is a routine lifesaving medical intervention which is generally regarded as safe when done properly. However, at the same time it also bears considerable risk. The aim of the study was to assess the serum IgE levels in patients experiencing transfusion-related allergic reactions after receiving fresh frozen plasma.

Methods: This cross-sectional observational study was conducted at the Department of Transfusion Medicine, BSMMU, from March 2019 to August 2021, focusing on patients aged 5 to 60 years receiving fresh frozen plasma. Patients were included after obtaining informed consent from themselves or their legal guardians in the case of minors, according to the eligibility criteria. Data were analyzed using SPSS version 26, with statistical significance set at p<0.05, employing Chi-square tests and Pearson’s correlation coefficient for variable comparisons.

Results: Raised IgE level was significantly related with transfusion related allergic reaction after receiving fresh frozen plasma (p<0.05). The mean IgE was 521.4±434.6 in patients with reaction and 67.8±33.2 in patients without reaction. Significant positive correlation was observed in serum IgE level with age in years.

Conclusions: Patients with transfusion related allergic reaction receiving fresh frozen plasma had higher mean IgE levels as compared to those without reaction.

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