A hospital-based study on acute on chronic liver failure underlying etiology and precipitating factors

Mahendra Manoj Pauskar; Prashanth B. Nadekar; Mahesh Managooli

doi:10.18203/2320-6012.ijrms20241902

Authors

Mahendra Manoj Pauskar Department of General Medicine, KLE’S, JGMM Medical College, Hubli, Karnataka, India
Prashanth B. Nadekar District Hospital, Yadgiri, Karnataka, India
Mahesh Managooli Department of Medical Oncology, Goa Medical College, Bambolim, Panaji, Goa, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20241902

Keywords:

ACLF, Alcohol, Chronic liver disease, Infections

Abstract

Background: Acute-on-chronic liver failure (ACLF) is an increasingly recognised entity that includes the acute deterioration of chronic liver disease usually associated with a precipitating event, development of one or more organ failure and high short-term mortality.

Methods: This is a prospective observational study. Clinical data of patients admitted with ACLF at Goa Medical College between November 2019 to November 2021 are summarized and analyzed using relevant statistical tests.

Results: A total of 70 patient’s data was collected. Most common cause of underlying chronic liver disease was alcohol (85.7%) followed by hepatitis B (4.3%), autoimmune diseases (4.3%), cryptogenic (4.3%) and hepatitis C (1.4%). Infections were the most common precipitating factors for ACLF (42.8%) followed by alcohol (28.5%), upper gastrointestinal bleeding (21.42%), drug (AKT) induced (1.42%), unknown cause (10%).

Conclusions: Infection and alcohol were found to be important precipitating factors. A multicentre study involving larger numbers of patients are required to know further details and to form a standard treatment protocol.

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