Suspected new syndrome: idiopathic chronic systemic inflammatory dryness – a case report

Authors

  • Soham Samajpaty Department of Internal Medicine, Russian National Research Medical University named after NI Pirogov, Moscow, Russian Federation

DOI:

https://doi.org/10.18203/2320-6012.ijrms20242232

Keywords:

Autoimmune disease, Dry eye disease, Toxoplasmosis, Anti-PM/Scl antibody, Inflammation, Sjogren’s syndrome, Systemic sclerosis

Abstract

The current article discusses a peculiar and identifies an atypical autoimmune disease termed as the idiopathic chronic systemic inflammatory dryness. In the reported case, the clinical signs are to some extent identical to Sjogren’s syndrome with dry eyes, dry mouth and dry vagina but the biomarkers are negative for it. On the other hand, the biomarker for systemic sclerosis is positive but no clinical signs or symptoms of it were present. The present case also has a probable association with history of toxoplasmosis. The article is of utmost importance in the discourse of development and research of concurrent immunology and understanding of autoimmune diseases.

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References

Wielosz E, Dryglewska M, Majdan M. The prevalence and significance of anti-PM/Scl antibodies in systemic sclerosis. Ann Agric Environ Med. 2021;28(1):189-92.

Hernández-Molina G, Leal-Alegre G, Michel-Peregrina M. The meaning of anti-Ro and anti-La antibodies in primary Sjögren's syndrome. Autoimmun Rev. 2011;10(3):123-5.

Stevens S, Gilbert C, Astbury N. How to measure intraocular pressure: applanation tonometry. Community Eye Health. 2007 Dec;20(64):74-5. Erratum in: Community Eye Health. 2008;21(66):34.

Saraf AS, Nath S. Revisiting Omega and Veraguth's Sign. Indian J Psychol Med. 2019;41(3):295-7.

Hallowell RW, Paik JJ. Myositis-associated interstitial lung disease: a comprehensive approach to diagnosis and management. Clin Exp Rheumatol. 2022;40(2):373-83.

D'Aoust J, Hudson M, Tatibouet S, Wick J; Canadian Scleroderma Research Group; Mahler M, Baron M, Fritzler MJ. Clinical and serologic correlates of anti-PM/Scl antibodies in systemic sclerosis: a multicenter study of 763 patients. Arthritis Rheumatol. 2014;66(6):1608-15.

Mavragani CP, Moutsopoulos HM. Sjögren syndrome. CMAJ. 2014;186(15):E579-86.

Witte T. Diagnostic markers of Sjögren's syndrome. Dev Ophthalmol. 2010;45:123-8.

Wielosz E, Dryglewska M, Majdan M. AB0631 The clinical consequences presence of ANTI-PM/SCL antibodies in systemic sclerosis. Ann Rheumat Dis. 2017;76:1273.

Xu S, Hu X, Wang J, Xu Q, Han Z, Zhou H, Gao M. Polymyositis and dermatomyositis biomarkers. Clin Chim Acta. 2023;547:117443.

Zarean M, Mastroeni P, Moghaddas E, Hosseini Farash BR, Raouf-Rahmati A, Jamali J, et al. Toxoplasmosis Frequency Rate in Rheumatoid Arthritis Patients in Northeastern Iran. Iran J Parasitol. 2022;17(3):325-31.

Aboukamar WA, Habib S, Tharwat S, Nassar MK, Elzoheiry MA, Atef R, et al. Association between toxoplasmosis and autoimmune rheumatic diseases in Egyptian patients. Reumatol Clin (Engl Ed). 2023;19(9):488-94.

Sasai M, Yamamoto M. Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection. Exp Mol Med 51, 1-10. Exp Mol Med. 2019;51:1-10.

Yang Z, Goronzy JJ, Weyand CM. Autophagy in autoimmune disease. J Mol Med (Berl). 2015;93(7):707-17.

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Published

2024-07-31

How to Cite

Samajpaty, S. (2024). Suspected new syndrome: idiopathic chronic systemic inflammatory dryness – a case report. International Journal of Research in Medical Sciences, 12(8), 3005–3008. https://doi.org/10.18203/2320-6012.ijrms20242232

Issue

Section

Case Reports