Neurogenesis and brain-derived neurotrophic factor levels in herbal therapy


  • Emma Kamelia Dental Health Study Program of Health Polytechnic, Tasikmalaya, West Java, Indonesia
  • Hadiyat Miko Dental Health Study Program of Health Polytechnic, Tasikmalaya, West Java, Indonesia
  • Marni Br Karo Midwifery Program of Medistra Health Higher School, Jakarta, Indonesia
  • Mochammad Hatta Departement Molecular Biology and Immunology Laboratory for Infection Diseases, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia



BDNF, Herbal therapy, Neurogenesis


Neurogenesis is the process of formation of new neurons from precursor cells that involves a series includes the proliferation, migration, differentiation, maturation and synapse formation. During the formation, some neurons will undergo a process of programmed cell death or apoptosis; it is related to the trophic factor / neurotrophin molecules of the substance that is to sustain life as BDNF cells found in the nervous system among other areas in the hippocampus. Problem neurogenesis is expected to reach 17% of the entire population, basic pathology due to reduced synapse, neurotransmitters and neuronal networks. Provision of adequate stimuli can trigger neurogenesis and synaptic plasticity in the nervous system. WHO estimates that 80% of the world population use herbal medicine for the treatment of major health considering safe and without side effects. Already many herb plants are currently used as a treatment for nerve. In a review of this article we try to give an overview illustration of our understanding of neurogenesis and BDNF with various problems related to the prospect of therapy for both of them, through the treatment of phytochemicals as an alternative treatment that is safe and effective, using several types of herbs below levels / doses used, how to work, and the methods used.


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How to Cite

Kamelia, E., Miko, H., Karo, M. B., & Hatta, M. (2016). Neurogenesis and brain-derived neurotrophic factor levels in herbal therapy. International Journal of Research in Medical Sciences, 4(11), 4654–4658.



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