Paroxysmal nocturnal hemoglobinuria presenting as acute renal injury
DOI:
https://doi.org/10.18203/2320-6012.ijrms20242632Keywords:
PNH, Intravascular hemolysis, Hemosiderin, AKIAbstract
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic hemolytic anemia characterized by persistent intravascular hemolysiswith occasional or frequent recurrent exacerbations. In addition to hemolysis, there may be, pancytopenia and a distinct tendency to venous thrombosis. This triad makes PNH a truly unique clinical condition; however, not all of these three features manifest on presentation. Not many reports of renal involvement in PNH are available in the literature. We report a case of acute kidney injury (AKI) due to PNH. This case shows AKI as one of the complications of PNH.
References
Satish S, Rajesh R, Kurian G, Seethalekshmi NV, Unni M, Unni VN. Recurrent acute renal failure. Indian J Nephrol. 2010;20(4):217.
Luzzatto L. Hemolytic anemias. In Jameson JL, Kasper DL, Longo DL, Fauci AS, Hauser SL, Loscalzo J, editors. Harrison’s Principles of Internal Medicine. 20th ed. New York: Mc Graw Hill. 2018;708-9.
Pu JJ, Brodsky RA. Paroxysmal nocturnal hemoglobinuria from bench to bedside. Clin Transl Sci. 2011;4(3):219-24.
Chow KM, Lai FM, Wang AY, Chan YL, Tang NL, Li PK. Reversible renal failure in paroxysmal nocturnal hemoglobinuria. Am J Kidney Dis. 2001;37(2):E17.
Parker CJ. Management of paroxysmal nocturnal hemoglobinuria in the era of complement inhibitory therapy. Hematology Am Soc Hematol Educ Program. 2011;2011:21-9.
Clarkson MR, Friedwald JF, Eustace JA, Rabb H. Acute Kidney injury in Brenner and Rector’s The Kidney. 8th ed. Brenner BM, editor. Philadelphia: Saunders. 2008;943-86.
Ram R, Adiraju KP, Gudithi S, Dakshinamurty KV. Renal manifestations in paroxysmal nocturnal hemoglobinuria. Indian J Nephrol. 2017;27(4):289-93.
Weitz IC. Thrombosis in patients with paroxysmal nocturnal hemoglobinuria. Semin Thromb Hemost. 2011;37(3):315-21.
Nair RK, Khaira A, Sharma A, Mahajan S, Dhinda A. Spectrum of renal involvement in Paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of literature. Int Urol Nephrol. 2008;40(2):471-5.
Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R, et al. Diagnosis and management of Paroxysmal nocturnal hemoglobinuria. Blood. 2005;106(12):3699-709.
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review. Eur J Haematol. 2015;95(3):190-8.
