Any help for the helpers? Determinants of female infertility in oocyte donors

Ese W. Omonigho; Okorie C. Anya; Ibilolia J. Kalio; Chidinma V. Keke; Kayode I. Adisa; Aminat A. Seriki; Gift I. Iheabunike; Stephen S. Hati

doi:10.18203/2320-6012.ijrms20242592

Authors

Ese W. Omonigho Department of Fertility and Reproductive Medicine, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria
Okorie C. Anya Department of Fertility and Reproductive Medicine, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria https://orcid.org/0009-0002-1514-3832
Ibilolia J. Kalio Department of Fertility and Reproductive Medicine, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria
Chidinma V. Keke Department of Embryology, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria
Kayode I. Adisa Department of Embryology, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria
Aminat A. Seriki Department of Nursing, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria
Gift I. Iheabunike Department of Nursing, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria
Stephen S. Hati Department of Quality Control and Assurance, Primecare Fertility Clinic, Garki Area 8, Abuja, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20242592

Keywords:

Female infertility, Oocyte donation, Poor ovarian response, Reproductive health, Sustainable developmental goals, Universal heath coverage

Abstract

Background: Female infertility is a national problem for the family, and one of the major causes is ovarian dysfunction. Ovarian function can decline with increasing age and other factors, and this can affect oocyte quality. One of the ways to manage it is through oocyte donation; however, some oocyte donors also suffer from ovarian dysfunction. The aim of this study was to identify the determinants of infertility in young, unmarried females, with the aim of planning treatment strategies that may help reduce the burden of infertility.

Methods: The study enrolled 335 individuals who presented for oocyte donation. The number of people who had their oocyte donation program cancelled due to fertility-related issues was analysed, and simple descriptive statistics were used for analysis.

Results: Of the 330 participants, the age range was between 21 and 27 years, with a mean age of 23 years. About 19% of the participants had their oocyte donation program cancelled, and out of this proportion, 47% of them experienced poor ovarian response to stimulation with either a low anti-mullerian hormone level or a low antral follicular count on day 2 of their menstrual cycle.

Conclusions: Identification and early management of this population of young females can invariably reduce the burden of infertility in the future.

Metrics

Metrics Loading ...

References

American Society for Reproductive Medicine. Committee opinion: Definition of infertility, 2023. Available at: https://www.asrm.org/practice-guidance/practice-committee-documents/denitions-of-infertility. Accessed on 1 May 2024.

Jabeen F, Khadija S, Daud S. Prevalence of primary and secondary infertility. Saudi J Med. 2022;7(1):22-8.

Sule J, Erigbali P, Eruom L. Prevalence of infertility in women in a southwestern Nigerian community. Afr J Biomed Res. 2008;11(2).

Obayi B, Ogbuji C. Prevalence of infertility among women of childbearing age attending selected clinics in Enugu State. Int J Hum Kinet Health Educ. 2018;4(2).

Dattijo L, Andreadis N, Aminu B, Umar N, Black K. The prevalence and clinical pattern of infertility in Bauchi, northern Nigeria. Trop J Obstet Gynecol. 2016;33(1):76-85.

Walker M, Tobler K. Female Infertility. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022:32310493.

Westhoff C, Murphy P, Heller D. Predictors of ovarian follicle number. Fertil Steril. 2000;74(4):624-8.

Tulay P, Atılan O. Oocyte donors’ awareness on donation procedure and risks: A call for developing guidelines for health tourism in oocyte donation programmes. J Turk Ger Gynecol Assoc. 2019;20(4):236.

American Society for Reproductive Medicine. Practice committee: Guidelines for oocyte donation, 2022. Available at: https://doi.org/10.1016/j.fertnstert.2004.06.021. Accessed on 1 May 2024.

Levi R, Tayfun Özçakir H, Adakan S, Göker E, Tavmergen E. Effect of ovarian cysts detected on the beginning day of ovulation induction to the success rates in ART cycles. J Obstet Gynaecol Res. 2003;29(4):257-61.

Buser J. Women’s reproductive rights are global human rights. J Transcult Nurs. 2022;33(5):565-6.

Das T, Holland P, Ahmed M, Husain L. Sustainable Development Goal 3: Good Health and Well-being. In: Das, T, Nayar PD, eds. South-East Asia Eye Health. Singapore: Springer; 2021:978-981.

World Health Organization. Universal health coverage partnership annual report. In: Team T, Perignon D. Health systems strengthening and health emergencies beyond COVID-19. World Health Organization; 2022.

Ogundeji Y, Tinuoye O, Bharali I, Mao W, Ohiri K, Ogbuoji O. Is Nigeria on course to achieve universal health coverage in the context of its epidemiological and financing transition? A knowledge, capacity and policy gap analysis (a qualitative study). BMJ Open. 2023;13(3):e064710.

Jingwen Y, Hsun-Ming C, Rong L, Peter L. Recent progress in the treatment of women with diminished ovarian reserve. Gynecol Obstet Clin Med. 2021;1(4):186-9.

Kaul-Mahajan N. Management of poor ovarian response. Fertil Reprod. 2023;5(04):307-7.