The effect of meditation on telomerase and stem cell
DOI:
https://doi.org/10.18203/2320-6012.ijrms20242638Keywords:
Meditation, Stem cell, TA, TLAbstract
Meditation has garnered increasing interest due to its potential effects on cellular aging processes, particularly telomere and stem cells. This narrative review aims to synthesize existing research on how meditation affects telomeres and stem cells. Meditation significantly influences telomere through stress reduction, immune system, inflammation, and oxidative stress modulation. Meditation has been shown to reduce stress, improve circadian rhythms, and modulate the hypothalamus-pituitary-adrenal (HPA) axis, thereby decreasing cortisol levels and promoting telomere maintenance. Melatonin, elevated through meditation, further supports telomere health by reducing oxidative stress and inflammation. Meditation also affects the activity of genes associated with inflammation and stress response, contributing to telomere integrity. Through increasing antioxidant defenses and reducing oxidative damage, meditation also reduces oxidative stress that can damage telomeres. In the context of stem cells, meditation may also increase telomerase activity (TA), which plays a role in maintaining telomere length (TL) and supporting stem cell function essential for tissue regeneration. Despite promising findings, gaps remain in understanding the precise mechanisms through which meditation modulates telomere and stem cells. Future research should further elucidate the mechanisms involved and explore the long-term implications of meditation on cellular aging processes.
References
Boccardi V, Paolisso G, Mecocci P. Nutrition and lifestyle in healthy aging: the telomerase challenge. Aging. 2016;8(1):12-5.
Jackson AS, Sui X, Hébert JR, Church TS, Blair SN. Role of Lifestyle and Aging on the Longitudinal Change in Cardiorespiratory Fitness. Arch Intern Med. 2009;169(19):1781-7.
Correia-Melo C, Hewitt G, Passos JF. Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? Longev Heal. 2014;3(1):1.
Armstrong L, Saretzki G, Peters H, Wappler I, Evans J, Hole N, et al. Overexpression of Telomerase Confers Growth Advantage, Stress Resistance, and Enhanced Differentiation of ESCs Toward the Hematopoietic Lineage. Stem Cells. 2005;23(4):516-29.
Nurkovic J, Volarevic V, Lako M, Armstrong L, Arsenijevic N, Stojkovic M. Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation. Rejuvenation Res. 2016;19(1):3-12.
Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145-7.
Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 2003;102(2):517-20.
Hiyama E, Hiyama K. Telomere and telomerase in stem cells. Br J Cancer. 2007;96(7):1020-4.
Lupatov AY, Yarygin KN. Telomeres and Telomerase in the Control of Stem Cells. Biomedicines. 2022;10(10):2335.
Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, et al. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res. 2011;21(5):779.
Fathi E, Charoudeh HN, Sanaat Z, Farahzadi R. Telomere shortening as a hallmark of stem cell senescence. Stem Cell Investig. 2019;6:7.
Galiè S, Canudas S, Muralidharan J, García-Gavilán J, Bulló M, Salas-Salvadó J. Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials. Adv Nutr. 2020;11(3):576-601.
Song S, Lee E, Kim H. Does Exercise Affect Telomere Length? A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicina (Mex). 2022;58(2):242.
Bossert L, Arzberger K, Dorok F, Kern J, Stickler C, Wunderlich M, et al. The Effects of Mindfulness-Based Interventions on Telomere Length and Telomerase Activity: A Systematic Review and Meta-Analysis. Mindfulness. 2023;14(3):495-509.
Dasanayaka NN, Sirisena ND, Samaranayake N. The effects of meditation on length of telomeres in healthy individuals: a systematic review. Syst Rev. 2021;10(1):151.
Dasanayaka NN, Sirisena ND, Samaranayake N. Impact of Meditation-Based Lifestyle Practices on Mindfulness, Wellbeing, and Plasma Telomerase Levels: A Case-Control Study. Front Psychol. 2022;13:846085.
Dasanayaka NN, Sirisena ND, Samaranayake N. Improving Mindfulness, Quality of Life, and Controlling Cellular Aging through Meditation. In: Well-Being Across the Globe-New Perspectives-Concepts, Correlates and Geography. IntechOpen; 2023.
Duraimani S, Schneider RH, Randall OS, Nidich SI, Xu S, Ketete M, et al. Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans. Eller K, editor. PLOS One. 2015;10(11):e0142689.
Lavretsky H, Epel ES, Siddarth P, Nazarian N, Cyr NSt, Khalsa DS, et al. A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity. Int J Geriatr Psychiatry. 2013;28(1):57-65.
Mendioroz M, Puebla-Guedea M, Montero-Marín J, Urdánoz-Casado A, Blanco-Luquin I, Roldán M, et al. Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners. Sci Rep. 2020;10(1):4564.
Rathore M, Abraham J. Implication of asana, pranayama and meditation on telomere stability. Int J Yoga. 2018;11(3):186-6.
Sapozhnikov D. Promise of Mindfulness-Based Interventions as Therapies to Prevent Cognitive Decline. McGill Sci Undergrad Res J. 2015;10(1):49-54.
Schutte NS, Malouff JM. A meta-analytic review of the effects of mindfulness meditation on telomerase activity. Psychoneuroendocrinology. 2014;42:45-8.
Sheikh-Wu SF, Liang Z, Downs CA. The Relationship Between Telomeres, Cognition, Mood, and Physical Function: A Systematic Review. Biol Res Nurs. 2023;25(2):22739.
Shen H, Chen M, Cui D. Biological mechanism study of meditation and its application in mental disorders. Gen Psychiatry. 2020;33(4):e100214.
Sung MK, Koh E, Kang Y, Lee JH, Park JY, Kim JY, et al. Three months-longitudinal changes in relative telomere length, blood chemistries, and self-report questionnaires in meditation practitioners compared to novice individuals during midlife. Medicine (Baltimore). 2022;101(41):e30930.
Thimmapuram J, Pargament R, Sibliss K, Grim R, Risques R, Toorens E. Effect of heartfulness meditation on burnout, emotional wellness, and telomere length in health care professionals. J Community Hosp Intern Med Perspect. 2017;7(1):21-7.
Tiwari A, Chan CLW, Ho RTH, Tsao GSW, Deng W, Hong AWL, et al. Effect of a qigong intervention program on telomerase activity and psychological stress in abused Chinese women: a randomized, wait-list controlled trial. BMC Complement Altern Med. 2014;14(1):300.
Tolahunase M, Sagar R, Dada R. Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open-Label Single-Arm Exploratory Study. Oxid Med Cell Longev. 2017;2017:7928981.
Williams-Orlando C. Loving-kindness Meditation in Psychology. Altern Complement Ther. 2016;22(3):111-6.
Epel ES, Daubenmier J, Moskowitz JT, Folkman S, Blackburn E. Can Meditation Slow Rate of Cellular Aging? Cognitive Stress, Mindfulness, and Telomeres. Ann N Y Acad Sci. 2009;1172(1):34-53.
Conklin QA, Crosswell AD, Saron CD, Epel ES. Meditation, stress processes, and telomere biology. Curr Opin Psychol. 2019;28:92-101.
Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, et al. Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication. Cell. 2009;138(1):90-103.
Bryan TM. G-Quadruplexes at Telomeres: Friend or Foe? Molecules. 2020;25(16):3686.
De Punder K, Heim C, Wadhwa PD, Entringer S. Stress and immunosenescence: The role of telomerase. Psychoneuroendocrinology. 2019;101:87-100.
Lin J, Epel E. Stress and telomere shortening: Insights from cellular mechanisms. Ageing Res Rev. 2022;73:101507.
Lavretsky H, Epel ES, Siddarth P, Nazarian N, Cyr NSt, Khalsa DS, et al. A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity. Int J Geriatr Psychiatry. 2013;28(1):57-65.
Pascoe MC, Thompson DR, Ski CF. Meditation and Endocrine Health and Wellbeing. Trends Endocrinol Metab. 2020;31(7):469-77.
Tang YY, Hölzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Rev Neurosci. 2015;16(4):213-25.
Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci. 2004;101(49):17312-5.
Shalev I. Early life stress and telomere length: Investigating the connection and possible mechanisms. BioEssays. 2012;34(11):943-52.
Conklin QA, King BG, Zanesco AP, Lin J, Hamidi AB, Pokorny JJ, et al. Insight meditation and telomere biology: The effects of intensive retreat and the moderating role of personality. Brain Behav Immun. 2018;70:233-45.
Tomiyama AJ, O’Donovan A, Lin J, Puterman E, Lazaro A, Chan J, et al. Does cellular aging relate to patterns of allostasis? An e`xamination of basal and stress reactive HPA axis activity and telomere length. Physiol Behav. 2012;106(1):40-5.
Savolainen K, Eriksson JG, Kajantie E, Lahti J, Räikkönen K. Telomere length and hypothalamic–pituitary–adrenal axis response to stress in elderly adults. Psychoneuroendocrinology. 2015;53:179-84.
Nelson BW, Allen NB, Laurent H. Infant HPA axis as a potential mechanism linking maternal mental health and infant telomere length. Psychoneuroendocrinology. 2018;88:38-46.
Choi J, Fauce SR, Effros RB. Reduced telomerase activity in human T lymphocytes exposed to cortisol. Brain Behav Immun. 2008;22(4):600-5.
Belsky J, Shalev I. Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? Dev Psychopathol. 2016;28(4pt2):1367-83.
Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. The Lancet. 2009;373(9678):1905-17.
Bauer ME. Stress, glucocorticoids and ageing of the immune system. Stress. 2005;8(1):69-83.
Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, et al. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology. 2006;31(3):277-87.
Suárez-Álvarez B, López-Vázquez A, López-Larrea C. Mobilization and Homing of Hematopoietic Stem Cells. 2012: 152–170.
Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska‐Wieczorek A, et al. Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis. STEM CELLS. 2005;23(7):879–94.
Fyfe-Johnson A, Taylor D, Zierold C, Dusek J. OA04.01. Effects of relaxation response intervention on endogenous progenitor cells in a hypertensive population. BMC Complement Altern Med. 2012;12(S1):13–13.
Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, et al. Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction. Circulation. 2005;112(10):1451–61.
