Assessment of video-laryngoscopic examination in patients of LPRD in a tertiary care hospital
DOI:
https://doi.org/10.18203/2320-6012.ijrms20242619Keywords:
Laryngopharyngeal reflux disease, Reflux symptom index, Reflux finding score, Tertiary hospitalAbstract
Background: Laryngopharyngeal reflux disease (LPRD) is characterized by vague symptoms, often leading to delayed presentation and advanced disease, potentially increasing the risk of malignancy. The extent and clinical features of this condition remain poorly understood among patients seeking Otorhinolaryngology services in Bihar.
Methods: This descriptive cross-sectional study was conducted at Narayan Medical College and Hospital within the Department of Otorhinolaryngology. It included patients exhibiting symptoms of Laryngopharyngeal reflux disease. Data collection utilized questionnaires and clinical examination forms, with analysis performed using Microsoft Excel. Results were presented through frequency tables, cross-tabulations, and figures.
Results: In this study, 210 participants were enrolled, of whom 137 (65.24%) were females. The median age was 35.5 years with an interquartile range of 21-50 years. The prevalence of Laryngopharyngeal reflux disease was found to be 18.57%, with no gender preference observed. The most common symptoms reported were globus sensation and hoarseness of voice, affecting 97.44% and 94.87% of participants, respectively. The most frequently observed signs included thick endo laryngeal mucus (94.87%) and erythema/hyperemia (84.62%). Risk factors identified included lying down within two hours after meals and consumption of spicy foods. The most prevalent comorbid conditions associated with Laryngopharyngeal reflux disease were hypertension and Type 2 diabetes Mellitus.
Conclusion: The prevalence of laryngopharyngeal reflux disease is high among patients attending Otorhinolaryngology services at Narayan medical College and hospital. All patients with laryngopharyngeal reflux disease related symptoms should get thorough evaluation for early diagnosis and treatment.
References
Cheung TK, Lam PK, Wei WI. Quality of life in patients with laryngopharyngeal reflux. Digestion. 2009;79:52-7.
Wong WM, Fass R. Extraesophageal and atypical manifestations of GERD. J Gastroenterol Hepatol. 2004;19(3):33-43.
Galli J, Cammarota G, Calo` L. The role of acid and
alkaline reflux in laryngeal squamous cell carcinoma. Laryngoscope. 2002;112:1861-5.
Tae K, Jin BJ, Ji YB, Jeong JH, Cho SH, Lee SH. The role of laryngopharyngeal reflux as a risk factor in laryngeal cancer: a preliminary report. Clin Exp Otorhinolaryngol. 2011;4:101-4.
Koufman JA, Aviv JE, Casiano RR, Shaw GY. Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American academy of otolaryngology-head and neck surgery. Otolaryngol Head Neck Surg. 2002;127:32-5.
Delahunty JE, Cherry J. Experimentally produced vocal cord granulomas. Laryngoscope. 1968;78:1941-7.
Miko TL. Peptic (contact ulcer) granuloma of the larynx. J Clin Pathol. 1989;42:800-4.
Morrison MD, Nichol H, Rammage LA. Diagnostic criteria in functional dysphonia. Laryngoscope. 1986;96:1-8.
Havas T, Priestley J, Lowinger D. Correlating classification of laryngopharyngeal reflux with treatment outcome. Aust J OtoLaryngology. 1998;3:153.
Cesari U, Galli J, Ricciardiello F, Cavaliere M, Galli V. Dysphonia and laryngopharyngeal reflux. Acta otorhinolaryngologica Italica. 2004;24:13-9.
Zucato B, Behlau MS. Laryngopharyngeal reflux symptoms index: relation with the main symptoms of gastroesophageal reflux, voice usage level and voice screening. Revista CEFAC. 2012;14:1197-203.
Ward PH, Hanson DG. Reflux as an etiological factor of carcinoma of the laryngopharynx. Laryngoscope. 1988;98:1195-9.
Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J. Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux. Gut. 2004;53:1730-5.
Lee YC, Lee JS, Kim SW, Kwon KH and Eun YG. Influence of age on treatmentwith proton pump inhibitors in patients with laryngopharyngeal reflux dis-ease: A prospective multicenter study. JAMA Otolaryngol Head Neck Surg. 2013;139(12):1291-5.
Vaezi MF, Hicks DM, Abelson TI and Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): A critical assessment of cause-and-effect association. Clin Gastroenterol Hepatol. 2003;1(5):333-44.
Merati AL, Lim HJ, Ulualp SO and Toohill RJ. Meta-analysis of upper probe measurements in normal subjects and patients with laryngopharyngeal reflux. Ann Otol Rhinol Laryngol. 2005;114(3):177-82.
Mishra P, Agarwal D, Chauhan K, kaushik M. Prevalence of laryngopharyngeal reflux disease in Indian population. Ind J Otolaryngol Head Neck Surg. 2020:1-5
Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope. 2001; 111:1313e1317.
Hamdan AL, Jaffal H, Btaiche R. Laryngopharyngeal symptoms in patients with asthma: a cross-sectional controlled study. Clin Respir J. 2016;10:40-7.
Nunes HS, Pinto JA, Zavanela AR, Cavallini AF, Freitas GS, Garcia FE. Comparison between the reflux finding score and the reflux symptom index in the practice of otorhinolaryngology. Int Arch Otorhinolaryngol. 2016;20:218-21.
Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA. 2005;294:1534-40.
El-Serag HB. Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol. 2007;5:17-26.
Altman KW, Stephens RM, Lyttle CS, Weiss KB. Changing impact of gastroesophageal reflux in medical and otolaryngology practice. Laryngoscope. 2005;115:1145-53.
Six A, Mariotti-Ferrandiz ME, Chaara W, et al. The past, present, and future of immune repertoire biology-the rise of nextgeneration repertoire analysis. Front Immunol. 2013;4:413.
Kamani T, Penney S, Mitra I, Pothula V. The prevalence of laryngopharyngeal reflux in the English population. Eur Arch Otorhinolaryngol. 2012;269:2219-25.
Spantideas N, Drosou E, Bougea A, Assimakopoulos D. Laryngopharyngeal reflux disease in the Greek general population, prevalence and risk factors. BMC Ear Nose Throat Disord. 2015;15:7.
Carr MM, Poje CP, Ehrig D, Brodsky LS. Incidence of reflux in young children undergoing adenoidectomy. Laryngoscope. 2001;111:2170-2.
Campagnolo AM, Priston J, Thoen RH, Medeiros T, Assunc¸a˜o AR. Laryngopharyngeal reflux: diagnosis, treatment, and latest research. Int Arch Otorhinolaryngol. 2014;18:184-91.
Vaezi MF, Hicks DM, Abelson TI, Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause-and-effect association. Clin Gastroenterol Hepatol. 2003;1:333-44.
de Bortoli N, Nacci A, Savarino E, et al. How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related. World J Gastroenterol. 2012;18:4363-70.
Van Rensburg CJ, Kulich KR, Carlsson J, Wiklund IK. What is the burden of illness in patients with reflux disease in South Africa? South Afr Gastroenterol Rev. 2005;3:16-21.
Murat S, Elif AA, Eser V, Mehmet K, Bahattin C. Risk factors for laryngopharyngeal refux. Eur Arch Otorhino. 2012;269:1189-94.
Spantideas N, Drosou E, Karatsis A, Assimakopoulos D. Voice disorders in the general Greek population and in patients with laryngopharyngeal reflux. Prevalence and risk factors. J Voice. 2015;29, 389.e27-32.
Hamdan AL, Jabbour J, Barazi R, Korban Z, Azar ST. Prevalence of laryngopharyngeal reflux disease in patients with diabetes mellitus. J Voice. 2013;27:495-99.
Moraes-Filho JP, Navarro-Rodriguez T, Eisig JN, Barbuti RC, Chinzon D, Quigley EM. Comorbidities are frequent in patients with gastroesophageal reflux disease in a tertiary health care hospital. Clinics (Sao Paulo). 2009;64:785-90.
Miura MS, Mascaro M, Rosenfeld RM. Association between otitis media and gastroesophageal reflux: a systematic review. Otolaryngol Head Neck Surg. 2012;146:345-52.
Hamdan AL, Jabbour J, Al Zaghal Z, Azar ST. Goiter and laryngopharyngeal reflux. ISRN Endocrinol. 2012;2089:58.