High-grade cervical leiomyosarcoma: a case report
DOI:
https://doi.org/10.18203/2320-6012.ijrms20242954Keywords:
Sarcoma, Leiomyosarcoma, Malignant tumor, Vaginal bleedingAbstract
Cervical leiomyosarcomas represent less than 1% of all malignant cervical neoplasms, predominantly affecting perimenopausal women, with an average age of diagnosis at 46 years. This article presents a case involving a 45-year-old female patient admitted to the gynecology department due to pyelonephritis. During initial evaluation, a cervical tumor was incidentally discovered. Histopathological analysis revealed findings consistent with high-grade leiomyosarcoma, not otherwise specified (NOS). The patient underwent surgical intervention, which included sigmoid resection, type III Piver hysterectomy, mechanical side-to-side colorectal anastomosis, appendectomy, placement of JJ stents, and terminal ureterovesical anastomosis. Leiomyosarcomas are associated with a poor prognosis, even when diagnosed at an early stage. The most prevalent symptom is abnormal vaginal bleeding. Surgical intervention is the primary treatment modality for this condition, with the objective of achieving an R0 resection, which entails the complete removal of the tumor.
References
Lebbe I, De Cuypere E, Claes N, Loccufier A, Ghysel C, Van Trappen P. Primary leiomyosarcoma of the uterine cervix: an unusual case and critical appraisal. Case report. J Surgical Case Rep. 2023;8:1-3.
Kiliç C, Dilek Y, Caner C, Osman T, Gunsu KC, Derman B, et al. Primary leiomyosarcoma of the uterine cervix: report of 4 cases, systematic review, and meta-analysis. Tumori J. 2020;100(5):1-5.
Momeni-Boroujeni A, Chiang S. Uterine mesenchymal tumours: recent advances. Histopathology. 2020;76(1):64-75.
Zhu M, Chen S. Clinical features of uterine sarcomas presenting mainly with uterine masses: a retrospective study. BMC Women's Health. 2023;23(394):1-5.
Adewole AA, Onile TG, Ugiagbe AO, Fadahunsi OO, Awelimobor DI, Akinro O. Cervical leiomyosarcoma in a teenage girl: A rare form of uterine leiomyosarcoma. J Taibah University Med Sci. 2021;17(3):523-8.
Kasper B, D'Ambrosio L, Elizabeth JD, Matthew I, Javier MB, Jonathan CT, et al. What Clinical Trials Are Needed for Treatment of Leiomyosarcoma? Curr Treatment Options Oncol. 2022;23(3):439-49.
Imura Y, Takenaka S, Outani H, Nakai T, Naohiro Y, Sho N, et al. Impact of Surgery and Chemotherapy on Metastatic Extrauterine Leiomyosarcoma. Curr Oncol. 2022;29(4):2301-11.
Lebbe I, De Cuypere E, Claes N, Loccufier A, Ghysel C, Van Trappen P. Primary leiomyosarcoma of the uterine cervix: an unusual case and critical appraisal. J Surgical Case Rep. 2023;(8):rjad439.
Vijaya Kumar Jayaram, Parikshith J, Narayanan GS, Tiwari R, Veena R, Prathima S, et al. Multimodality management of leiomyosarcoma of the cervix. E Cancer. 2018;12(830):1-8.
Bhatia V, Taksande R, and Natekar A, Ali Z. Cervical leiomyosarcoma: a rare entity. South Afr J Gynaecol Oncol. 2015;7(2):64-6.
Villalobos V, Silva A, Belmonte G, Bermudez Ruiz JDR, Mojica YMR, De Brito CMM, et al. Current Status of Cancer Rehabilitation in Latin America Current Physical Medicine and Rehabilitation Report. Curr Physical Med Rehabilit Rep. 2024;12(1):126-37.
